Differences in the distribution of iodine and iodide in the Sprague-Dawley rat

Thrall, Karla D.; Bull, Richard J.

doi:10.1016/0272-0590(90)90164-f

Cited by 30 publications

(5 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a series of NASA funded studies, Thrall demonstrated dramatic differences in the pharmacological and toxicological properties of orally administered iodide versus I2 in rat [32][33][34]; her results support the principal that the functional properties of an iodine composition depend upon the relative concentration of the different iodine species contained therein. Aceves and others have demonstrated a dramatic different in the behaviour of I2 versus iodide in different cell lines and tissues [32,33,35,36].…”

Section: Discussionmentioning

confidence: 85%

“…If we assume 20% absorption as opposed to the 5% Braverman measured, then 40 µg would cross the stratum corneum. A maximum of 50% of this I2 could be available partition into the thyroid [32][33][34] which equates to a total thyroid exposure of 20 µg of iodide which is about 15% of the RDA. Consequently, it would be important to measure the potential for iodine exposure from repeat applications of a high I2-glycerine composition.…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

See 1 more Smart Citation

Molecular iodine is not responsible for cytotoxicity in iodophors

Freeman¹,

Duan²,

Kessler³

2022

Journal of Hospital Infection

View full text Add to dashboard Cite

This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

show abstract

Section: Discussionmentioning

confidence: 85%

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

Molecular iodine is not responsible for cytotoxicity in iodophors

Freeman¹,

Duan²,

Kessler³

2022

Journal of Hospital Infection

View full text Add to dashboard Cite

show abstract

“…The distribution and action of iodine in organisms depend on the chemical form of iodine that is ingested. For example, molecular iodine (I 2 ) is not reduced to iodide (I − ) in the blood before being absorbed in the gastrointestinal tract [ 11 ], induces differential effects [ 12 ], and its capture is 40% lower in the thyroid [ 13 ]. In fact, under conditions of iodine deficiency, I − appears to be more efficient than I 2 in restoring the thyroid gland to normality in goiter stages, while I 2 is more effective in decreasing mammary alterations secondary to iodine deficiency [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Molecular Iodine Has Extrathyroidal Effects as an Antioxidant, Differentiator, and Immunomodulator

Aceves¹,

Mendieta²,

Anguiano³

et al. 2021

IJMS

View full text Add to dashboard Cite

Most investigations of iodine metabolism in humans and animals have focused on its role in thyroid function. However, considerable evidence indicates that iodine could also be implicated in the physiopathology of other organs. We review the literature that shows that molecular iodine (I2) exerts multiple and complex actions on the organs that capture it, not including its effects as part of thyroid hormones. This chemical form of iodine is internalized by a facilitated diffusion system that is evolutionary conserved, and its effects appear to be mediated by a variety of mechanisms and pathways. As an oxidized component, it directly neutralizes free radicals, induces the expression of type II antioxidant enzymes, or inactivates proinflammatory pathways. In neoplastic cells, I2 generates iodolipids with nuclear actions that include the activation of apoptotic pathways and the inhibition of markers related to stem cell maintenance, chemoresistance, and survival. Recently, I2 has been postulated as an immune modulator that depending on the cellular context, can function as an inhibitor or activator of immune responses. We propose that the intake of molecular iodine is increased in adults to at least 1 mg/day in specific pathologies to obtain the potential extrathyroid benefits described in this review.

show abstract

“…Iodine is crucial for synthesizing thyronine and maintaining the epithelial integrity of thyroid follicles 6. Different chemical forms of iodine can be differentially taken up and metabolized in the tissues 7. The thyroid gland preferentially internalizes iodide (I − ), whereas nubile mammary gland takes up I 2 and I − to the same extent 8.…”

Section: Introductionmentioning

confidence: 99%