Differences in the gut Firmicutes to Bacteroidetes ratio across age groups in healthy Ukrainian population

Vaiserman, Alexander; Romanenko, Mariana; Piven, Liubov; Moseiko, Vladislav; Lushchak, Oleh; Kryzhanovska, Nadiia; Guryanov, Vitaly; Koliada, Alexander

doi:10.1186/s12866-020-01903-7

Cited by 137 publications

(88 citation statements)

References 58 publications

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“…The gut microbiota diversity is generally believed to change with age [ 44 , 52 ], and our cohort was not an exception, as age accounted for several percent of the variance in the Lachnospiraceae family, the second-ranked family in terms of relative abundance in the Firmicutes phylum; its Blautia genus; and Blautia wexlerae , one of the main dominant species in the study, with a ca. 2% abundance.…”

Section: Discussionmentioning

confidence: 99%

The Core of Gut Life: Firmicutes Profile in Patients with Relapsing-Remitting Multiple Sclerosis

Kozhieva

Naumova

Alikina

et al. 2021

Life

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The multiple sclerosis (MS) incidence rate has been increasing in Russia, but the information about the gut bacteriobiome in the MS-afflicted patients is scarce. Using the Illumina MiSeq sequencing of 16S rRNA gene amplicons, we aimed to analyze the Firmicutes phylum and its taxa in a cohort of Moscow patients with relapsing-remitting MS, assessing the effects of age, BMI, disease modifying therapy (DMT), disability (EDSS), and gender. Among 1252 identified bacterial OTUs, 857 represented Firmicutes. The phylum was the most abundant also in sequence reads, overall averaging 74 ± 13%. The general linear model (GLM) analysis implicated Firmicutes/Clostridia/Clostridiales/Lachospiraceae/Blautia/Blautia wexlerae as increasing with BMI, and only Lachospiraceae/Blautia/Blautia wexlerae as increasing with age. A marked DMT-related decrease in Firmicutes was observed in females at the phylum, class (Clostridia), and order (Clostridiales) levels. The results of our study implicate DMT and gender as factors shaping the fecal Firmicutes assemblages. Together with the gender-dependent differential MS incidence growth rate in the country, the results suggest the likely involvement of gender-specific pathoecological mechanisms underlying the occurrence of the disease, switching between its phenotypes and response to disease-modifying therapies. Overall, the presented profile of Firmicutes can be used as a reference for more detailed research aimed at elucidating the contribution of this core phylum and its lower taxa into the etiology and progression of relapsing-remitting multiple sclerosis.

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Section: Discussionmentioning

confidence: 99%

The Core of Gut Life: Firmicutes Profile in Patients with Relapsing-Remitting Multiple Sclerosis

Kozhieva

Naumova

Alikina

et al. 2021

Life

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“…Quantity estimation of Actinobacteria, Firmicutes and Bacteroidetes phyla has been conducted using a real-time thermocycler Rotor-Gene 6000 (QIAGEN, Hilden, Germany) by method described previously [ 28 ]. PCR reactions were performed in the following conditions: an initial denaturation for 5 min at 95 °C, 30 cycles of amplification and a a final elongation at 72 °C for 5 min.…”

Section: Methodsmentioning

confidence: 99%

Sex differences in the phylum‐level human gut microbiota composition

Koliada¹,

Moseiko²,

Romanenko

et al. 2021

BMC Microbiol

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Background Evidence was previously provided for sex-related differences in the human gut microbiota composition, and sex-specific discrepancy in hormonal profiles was proposed as a main determinant of these differences. On the basis of these findings, the assumption was made on the role of microbiota in the sexual dimorphism of human diseases. To date, sex differences in fecal microbiota were demonstrated primarily at lower taxonomic levels, whereas phylum-level differences between sexes were reported in few studies only. In the present population-based cross-sectional research, sex differences in the phylum-level human gut microbiota composition were identified in a large (total n = 2301) sample of relatively healthy individuals from Ukraine. Results Relative abundances of Firmicutes and Actinobacteria, as determined by qRT-PCR, were found to be significantly increased, while that of Bacteroidetes was significantly decreased in females compared to males. The Firmicutes to Bacteroidetes (F/B) ratio was significantly increased in females compared to males. Females had 31 % higher odds of having F/B ratio more than 1 than males. This trend was evident in all age groups. The difference between sexes was even more pronounced in the elder individuals (50+): in this age group, female participants had 56 % higher odds of having F/B ratio > 1 than the male ones. Conclusions In conclusion, sex-specific differences in the phylum-level intestinal microbiota composition were observed in the Ukraine population. The F/B ratio was significantly increased in females compared to males. Further investigation is needed to draw strong conclusions regarding the mechanistic basis for sex-specific differences in the gut microbiota composition and regarding the role of these differences in the initiation and progression of human chronic diseases.

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“…The altered gut microbial state or 'dysbiosis' can be attributed to loss of beneficial organisms, proliferation of harmful pathogenic genera or overall decrease in microbial diversity (DeGruttola et al, 2016). For instance, studies have shown that agerelated gut dysbiosis generally results in enhanced growth of facultative anaerobes, decreased numbers of beneficial probiotic bacterial species and an altered firmicutes/bacteroidetes ratio (Salazar et al, 2017;Vaiserman et al, 2020). There is enough evidence available to suggest a correlation between gut dysbiosis, longevity and the prevalence of chronic disorders (Cardenas et al, 2014;Kamo et al, 2017;Lee et al, 2019).…”

Section: Gut Microbiota In Aging and Associated Diseasesmentioning

confidence: 99%

Gut Microbiome and Cellular Senescence in the Context of Aging and Disease: An Emerging Frontier

Sharma¹

2021

Preprint

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The significance of diversity, composition, and functional attributes of the gut microbiota is recognized in human health and disease. Studies have also shown that the gut microbiota is related to human aging, and a causal relationship between gut microflora dysbiosis and chronic age-related disorders is also becoming apparent. Further, emerging evidence indicates that age-associated changes in the gut microbiome are predictors of human survival and longevity. Recent advances in our understanding of the cellular and molecular aspects of biological aging have revealed a cellular senescence-centric view of the aging process. However, the association between gut microbiome and cellular senescence is only beginning to be understood. The present review provides an integrative view of the emerging relationship between the gut microbiome and cellular senescence in aging and disease. Evidence relating to microbiome-mediated modulation of senescent cells, as well as senescent cells-mediated changes in intestinal homeostasis have been discussed. Unanswered questions and future research directions have also been deliberated to truly ascertain the relationship of the gut microbiome and cellular senescence for developing microbiome-based age-delaying and longevity promoting therapies.

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Differences in the gut Firmicutes to Bacteroidetes ratio across age groups in healthy Ukrainian population

Cited by 137 publications

References 58 publications

The Core of Gut Life: Firmicutes Profile in Patients with Relapsing-Remitting Multiple Sclerosis

The Core of Gut Life: Firmicutes Profile in Patients with Relapsing-Remitting Multiple Sclerosis

Sex differences in the phylum‐level human gut microbiota composition

Gut Microbiome and Cellular Senescence in the Context of Aging and Disease: An Emerging Frontier

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