Differences in the interaction of water with starch and chitosan films as revealed by infrared spectroscopy and differential scanning calorimetry

Rueda, Daniel R.; Secall, T.; Bayer, R. K.

doi:10.1016/s0144-8617(99)00033-8

“…The gelatin/ chitosan films had wider peaks in that region, possibly due to strong interactions between gelatin and chitosan. This result agreed with those reported by Rueda, Secall, Bayer (1999);Mansur, Oréfice, Mansur (2004) who observed a broadened peak around 3400 cm …”

Section: Ftirsupporting

confidence: 94%

“…The Q ∞ slightly decreased with the chitosan content increasing in SIF and SCF; Q ∞ was smaller when the chitosan content was 50%-80%. These results agreed with studies that reported composite films improved mechanical strength (McConnell, Murdan, Basit, 2008) and swelling capability of films (Rueda, Secall, Bayer, 1999). advantages in biomaterials.…”

Section: Influence Of the Simulated Gastrointestinal Tract Environmensupporting

confidence: 92%

Design and preparation of a novel colon-targeted tablet of hydrocortisone

Ren

¹

,

Jiang

²

,

Yang

³

et al. 2017

Braz. J. Pharm. Sci.

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The objective of this research was to design a new colon-targeted drug delivery system based on chitosan. The properties of the films were studied to obtain useful information about the possible applications of composite films. The composite films were used in a bilayer system to investigate their feasibility as coating materials. Tensile strength, swelling degree, solubility, biodegradation degree, Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), Scanning Electron Microscope (SEM) investigations showed that the composite film was formed when chitosan and gelatin were reacted jointly. The results showed that a 6:4 blend ratio was the optimal chitosan/gelatin blend ratio. In vitro drug release results indicated that the Eudragit-and chitosan/gelatin-bilayer coating system prevented drug release in simulated intestinal fluid (SIF) and simulated gastric fluid (SGF). However, the drug release from a bilayer-coated tablet in SCF increased over time, and the drug was almost completely released after 24h. Overall, colon-targeted drug delivery was achieved by using a chitosan/gelatin complex film and a multilayer coating system.

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“…The Q ∞ slightly decreased with the chitosan content increasing in SIF and SCF; Q ∞ was smaller when the chitosan content was 50%-80%. These results agreed with studies that reported composite films improved mechanical strength (McConnell, Murdan, Basit, 2008) and swelling capability of films (Rueda, Secall, Bayer, 1999).…”

Section: Influence Of the Simulated Gastrointestinal Tract Environmensupporting

confidence: 93%

Design and preparation of a novel colon-targeted tablet of hydrocortisone

Ren

¹

,

Jiang

²

,

Yang

³

et al. 2016

Braz. J. Pharm. Sci.

View full text Add to dashboard Cite

The objective of this research was to design a new colon-targeted drug delivery system based on chitosan. The properties of the films were studied to obtain useful information about the possible applications of composite films. The composite films were used in a bilayer system to investigate their feasibility as coating materials. Tensile strength, swelling degree, solubility, biodegradation degree, Fourier transform infrared spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), Scanning electron microscope (SEM) investigations showed that the composite film was formed when chitosan and gelatin were jointly reacted jointly. The results showed that a 6:4 blend ratio was the optimal chitosan/gelatin blend ratio. In vitro drug release results indicated that the Eudragit-and chitosan/gelatin-bilayer coating system prevented drug release in simulated intestinal fluid (SIF) and simulated gastric fluid (SGF). However, the drug release from a bilayer-coated tablet in SCF increased over time, and the drug was almost completely released after 24 h. Overall, colon-targeted drug delivery was achieved by using a chitosan/ gelatin complex film and a multilayer coating system. Uniterms: Chitosan/gelatin complex film/drugs coating. Chitosan/multilayer coating system/drugs coating. Drugs/delivery system/colon-targeted. Tablets/bilayer-coated.O objetivo desta pesquisa foi planejar um novo sistema de liberação de fármacos direcionado ao cólon, utilizando quitosana. Estudaram-se as propriedades dos filmes a fim de obter informações úteis sobre a aplicação desses filmes compósitos. Utilizaram-se os filmes compósitos em sistema de bicamada para investigar a sua viabilidade como materiais de revestimento. Estudos de resistência à tração, grau de intumescimento, solubilidade, grau de biodegradação, no infravermelho por transformada de Fourier (FTIR), de calorimetria diferencial de varredura (DSC) e de microscopia eletrônica de varredura (SEM) mostraram que o filme compósito se formou quando a quitosana e a gelatina reagiram entre si. Os resultados mostraram que a mistura de proporção ótima foi de 6:4 de quitosana:gelatina. Resultados da liberação do fármaco in vitro indicaram que o sistema de revestimento de Eudragit e bicamada de quitosana/gelatina impediu a liberação de fármaco em fluido intestinal simulado (SIF) e em fluido gástrico simulado (SGF). Entretanto, a liberação de fármaco do comprimido revestido em bicamada no SCF aumentou ao longo do tempo e o fármaco foi quase completamente liberado após 24 h. Em geral, se obteve a forma de liberação dirigida ao cólon, utilizando filme complexo de quitosana/gelatina e sistema de revestimento multicamada.Unitermos: Quitosana/filme de complexo de gelatina. Quitosana/sistema multicamadas de revestimento/ revestimento de fármacos. Fármacos/sistema de liberação/dirigido ao cólon. Comprimidos/revestidos com bicamada.

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“…In DSC plot, a broad endothermic peak, related to dehydration phenomenon [39,40], was initially observed at about 100°C. The position of the endotherm peak was centered at about 133°C.…”

Section: Resultsmentioning

confidence: 99%

Preparation and characterization of chitosan membranes by using a combined freeze gelation and mild crosslinking method

Orrego

¹

,

Valencia

²

2008

Bioprocess Biosyst Eng

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When gelification is performed by freezing-thawing repeated cycles, the resultant gel-like polymer systems are called cryogels. This work aims to assess the effect of the addition of glutaraldehyde and 18 Crown Ether-6 on surface properties and protein loading of dried chitosan cryogel films. Residual water content of treated chitosan membranes ranged between 11.93 and 13.86%, while their water activities vary from 0.5 to 0.7 (measured from 4 to 60 degrees C). Based on thermal data, water evaporation peak and degradation temperatures of chitosan membranes shifted to a higher temperature for crosslinked samples. X-ray diffractograms provide high values of crystallinity for all the samples (70.67-92.86%), the highest value being for the glutaraldehyde-treated membrane. Candida rugosa lipase can be immobilized successfully on chitosan membranes. Lipase immobilized on glutaraldehyde-crosslinked chitosan yielded the highest efficiency in terms of total coupled protein and protein loading efficiency.

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Differences in the interaction of water with starch and chitosan films as revealed by infrared spectroscopy and differential scanning calorimetry

Cited by 87 publications

References 11 publications

Design and preparation of a novel colon-targeted tablet of hydrocortisone

Design and preparation of a novel colon-targeted tablet of hydrocortisone

Design and preparation of a novel colon-targeted tablet of hydrocortisone

Preparation and characterization of chitosan membranes by using a combined freeze gelation and mild crosslinking method

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