Differences in the morphology and duration between premature P waves and the preceding sinus complexes in patients with a history of paroxysmal atrial fibrillation

Dilaveris, Polychronis; Pantazis, Antonios; Zervopoulos, George; Kallikazaros, John; Stefanadis, Christodoulos; Toutouzas, Pavlos

doi:10.1002/clc.4950260709

Cited by 4 publications

(1 citation statement)

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“…Chen et al [34] more deeply investigated the electrophysiologic characteristics of both the ectopic beats originating from the PVs and the atrium and found that the electrophysiologic characteristics of the PVs were different from those in the atria. The major source of ectopic beats initiating paroxysmal AF is from PVs, and premature P wave patterns may help to identify the source of firing [35]. However, Chen's group reported one subgroup of focal AF is a right atrial focal AF that they observed in 4.7-6.2% of patients who had clinically documented attacks of paroxysmal AF [36].…”

Section: The Electrophysiological Properties Of Triggers In Afmentioning

confidence: 97%

The Role of Renin Angiotensin System Blockade in the Treatment of Atrial Fibrillation

Dilaveris¹,

Γιαννόπουλος²,

Synetos³

et al. 2005

CDTCHD

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Atrial fibrillation (AF) is the most common cardiac arrhythmia seen in clinical practice. The understanding of the pathophysiology of AF has changed drastically during the last several decades. Recent observations have challenged the concept of the multiple circuit reentry model in favor of single focus or single circuit reentry models. Atrial electrical dysfunction provides a favorable substrate and transmembrane ionic currents are key determinants. Recent research is focusing increasingly on the atrial structural remodeling, which underlies the development of AF in different pathological conditions. This has led to concepts about how interfering with the substrate might prevent AF development and recurrence. Particular interest has been generated in the role of renin angiotensin system (RAS) blockade in reversing the electrical and structural remodeling of diseased atria. The mechanisms for the preventive effect of angiotensin converting enzyme inhibitors (ACEi) or angiotensin-II (AT-II) type 1 receptor blockers (ARB) in AF are probably complex. They may comprise general haemodynamic changes leading to lower intra-atrial pressure and wall-stress, or reduce in atrial fibrosis, connexin43 over-expression and conduction delay. The promising results of several clinical trials concerning RAS blockade may herald a whole new era of AF treatment, where AF is prevented and treated by modifying its substrate rather than fighting it electrically. This review centers on the pathophysiology of the structural and electrical remodeling in AF, the possible mechanisms by which RAS blockade may reverse electrical and structural remodeling of diseased atria and on the role of ACEi or ARB blockers in AF prevention and treatment that has already been postulated both experimentally and clinically.

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Section: The Electrophysiological Properties Of Triggers In Afmentioning

confidence: 97%