Differences in the Prevalence of Human Papillomavirus (HPV) in Head and Neck Squamous Cell Cancers by Sex, Race, Anatomic Tumor Site, and HPV Detection Method

D’Souza, Gypsyamber; Westra, William H.; Wang, Steven J.; Zante, Annemieke van; Wentz, Alicia; Kluz, Nicole; Rettig, Eleni M.; Ryan, William R.; Ha, Patrick K.; Kang, Hyunseok; Bishop, Justin A.; Quon, Harry; Kiess, Ana P.; Richmon, Jeremy D.; Eisele, David W.; Fakhry, Carole

doi:10.1001/jamaoncol.2016.3067

Cited by 122 publications

(135 citation statements)

References 24 publications

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“…While OPSCC incidence remains lower among Hispanic than White men, it is steadily increasing among Hispanic men in parallel fashion to White men with dramatic increase in recent years (2006-2014: APC 5.4, p=0.003). Prior work has shown that prevalence of HPV-positive tumors has increased over time across races 6 , indicating that HPV is also driving incidence trends among these other racial groups. Among Blacks, the proportion of OPSCC caused by HPV is increasing 6 , suggesting the dramatic reduction in incidence of OPSCC among Blacks driven by reduction in tobacco and alcohol related cancers would be even larger if not for the increasing contribution of HPV-positive cancers in Blacks.…”

Section: Discussionmentioning

confidence: 99%

“…Prior work has shown that prevalence of HPV-positive tumors has increased over time across races 6 , indicating that HPV is also driving incidence trends among these other racial groups. Among Blacks, the proportion of OPSCC caused by HPV is increasing 6 , suggesting the dramatic reduction in incidence of OPSCC among Blacks driven by reduction in tobacco and alcohol related cancers would be even larger if not for the increasing contribution of HPV-positive cancers in Blacks. Among women, the previous racial disparity in OPSCC incidence between Whites and Blacks no longer exists.…”

Section: Discussionmentioning

confidence: 99%

“…Incidence of OPSCC is increasing among older, not just younger individuals, 5 and HPV is responsible for an increasing proportion of OPSCCs among women and non-Whites. 6 The incidence of oral cavity SCC in younger women and more recent birth cohorts of White men and women also appears to be increasing, 7–9 however the incidence of non-oropharyngeal HNSCC overall decreased between 1995-2005. 10 There is no recent examination of incidence of the major non-oropharyngeal anatomic sites overall, by sex, or race.…”

Section: Introductionmentioning

confidence: 99%

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Head and neck squamous cell cancers in the United States are rare and the risk now is higher among white individuals compared with black individuals

Fakhry

Krapcho

Eisele

et al. 2018

Cancer

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Background The increasing incidence of oropharynx squamous cell cancer (OPSCC) is well established. However, up-to date incidence estimates and trends for head and neck squamous cell cancers (HNSCC) overall including major anatomic sites and non-oropharyngeal (non-OP) HNSCCs by sex, race and age in the United States (US) are not well described. Methods Retrospective analysis of incident HNSCCs during 1992-2014 using Surveillance, Epidemiology, and End Results (SEER) database was used to evaluate incidence of HNSCCs overall, OPSCC and non-OP HNSCC (larynx, oral cavity, hypopharynx, nasopharynx, nasal cavity). Incidence rates were calculated overall and by subgroups of interest, and incidence rate ratios (IRR) were used to compare rates between groups. The incidence rates presented are per 100,000 people and age-adjusted to the 2000 US Standard Population (19 age groups – Census P25-1130). Annual percent change (APC) was modeled with and without joinpoints Results Incidence of HNSCC overall declined (average APC [aAPC] -0.8, p<0.001) in spite of significant increases in incidence of OPSCCs, most notably between 2000-2014 (APC=2.1, p<0.001). Indeed, significant declines in incidence were observed for all non-OP HNSCC sites, for both women and men (each p<0.001). Among women, risk of OPSCC also significantly decreased (aAPC -0.8, p=0.002), while among men OPSCC risk was stable during 1992-2001 (APC 0.4, p=0.42), then significantly increased during 2001-2014 (APC 2.7, p<0.001). Decreases in non-OP HNSCC risk were especially large for Black women (aAPC -2.6, p<0.001) and men (aAPC -3.0, p<0.001). While incidence of HNSCC used to be highest among Blacks, since 2009 HNSCC incidence is higher among Whites than Blacks. Conclusions Incidence of HNSCC is declining, especially for non-OP HNSCC and Blacks.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Head and neck squamous cell cancers in the United States are rare and the risk now is higher among white individuals compared with black individuals

Fakhry

Krapcho

Eisele

et al. 2018

Cancer

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“…found that the prevalence of HPV was different among all racial groups [26]. Previous studies showed that HPV infection is strongly correlated with p16 overexpression in LSCC [4].…”

Section: Tong Et Al: Prognostic Significance Of Hpc In Laryngeal Cancermentioning

confidence: 92%

Prevalence and Prognostic Significance of HPV in Laryngeal Squamous Cell Carcinoma in Northeast China

Tong

Geng

Yan

et al. 2018

Cell Physiol Biochem

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Background/Aims: Human papillomavirus (HPV) is an etiological risk factor for a subset of head and neck squamous cell carcinomas. HPV has been proven to be a powerful prognostic biomarker for oropharyngeal cancer, but its role in the larynx has not been explored in depth. Here, we sought to evaluate the prevalence and genotype distribution of HPV in patients with laryngeal squamous cell carcinoma (LSCC) in northeast China. Methods: HPV DNA in specimens from 211 patients diagnosed with LSCC was analyzed by the polymerase chain reaction and in situ hybridization, and p16 overexpression was evaluated by immunohistochemistry. p16 expression was scored positive if strong and diffuse nuclear and cytoplasmic staining was present in >75% of tumor cells. Results: In this study, infection with HPV and p16 expression were not absolutely consistent. Among all patients, 132 (62.6%) were positive for HPV DNA (HPV+), while 23 (10.9%) were inconsistent for HPV and p16. Multivariate analysis indicated that HPV, but not p16, is an independent prognostic factor for overall survival in LSCC. Overall survival was significantly improved in HPV+ LSCC patients compared with the HPV-negative group (hazard ratio, 0.395; 95% confidence interval, 0.185-0.843; p = 0.016). Among the 132 HPV+ patients, 28 (21.2%) were HPV-16 single infection. Conclusion: This study indicates that HPV DNA is a more reliable surrogate marker than p16 for the prediction of survival in patients with LSCC.

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“…[1][2][3] This rising incidence is attributed to oncogenic human papillomavirus (HPV). 7,9,10 Whether these trends apply more broadly in the United States is unknown. 7,9,10 Whether these trends apply more broadly in the United States is unknown.…”

Section: Introductionmentioning

confidence: 99%

The prevalence of human papillomavirus in oropharyngeal cancer is increasing regardless of sex or race, and the influence of sex and race on survival is modified by human papillomavirus tumor status

Faraji

Rettig

Tsai

et al. 2018

Cancer

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BACKGROUND:The purpose of this study was to evaluate the influence of sex and race/ethnicity upon prevalence trends of human papillomavirus (HPV) in oropharyngeal cancer (OPC) and survival after OPC. METHOD: This was a cohort study of patients included in the United States National Cancer Database who had been diagnosed with OPC between 2010 and 2015. Outcomes were HPV status of tumor specimens and overall survival. Sex-and race-stratified trends in HPV prevalence were estimated using generalized linear modeling. The influence of sex, race, and HPV tumor status on overall survival was compared by Kaplan-Meier method and Cox Proportional Hazards models. RESULTS: This analysis included 20,886 HPV-positive and 10,364 HPV-negative OPC patients. The prevalence of HPV-positive tumors was higher among men (70.6%) than women (56.3%) and increased significantly over time at a rate of 3.5% and 3.2% per year among men and women, respectively. The prevalence of HPV-positive tumors was highest among whites (70.2%), followed by Hispanics (61.3%), Asians (55.8%), and blacks (46.3%). Blacks and Hispanics experienced significantly more rapid increases in prevalence of HPV-positive tumors over time compared with whites (6.5% vs 5.6% vs 3.2% per year, respectively). In HPV-positive OPC, neither sex nor race/ethnicity was associated with survival among patients with HPV-positive OPC. In contrast, for HPV-negative OPC, risk of death was significantly higher for women versus men (adjusted hazard ratio [aHR], 1.17; 95% confidence interval [CI], 1.08-1.26) and blacks versus whites (aHR, 1.21; 95% CI, 1.10-1.33). CONCLUSION: The prevalence of HPVpositive tumors is increasing for all sex and race/ethnicity groups in the United States. Sex and race are independently associated with survival for HPV-negative but not HPV-positive OPC. Cancer 2019;125:761-769.

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Differences in the Prevalence of Human Papillomavirus (HPV) in Head and Neck Squamous Cell Cancers by Sex, Race, Anatomic Tumor Site, and HPV Detection Method

Cited by 122 publications

References 24 publications

Head and neck squamous cell cancers in the United States are rare and the risk now is higher among white individuals compared with black individuals

Head and neck squamous cell cancers in the United States are rare and the risk now is higher among white individuals compared with black individuals

Prevalence and Prognostic Significance of HPV in Laryngeal Squamous Cell Carcinoma in Northeast China

The prevalence of human papillomavirus in oropharyngeal cancer is increasing regardless of sex or race, and the influence of sex and race on survival is modified by human papillomavirus tumor status

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