Differences in the structure of drinking, cart expression and dopamine turnover between polydipsic and non polydipsic rats in the quinpirole model of psychotic polydipsia

Schepisi, Chiara; Cianci, Silvia; Bedse, Gaurav; Fu, Jin; Gaetani, Silvana; Nencini, Paolo

doi:10.1007/s00213-014-3527-0

Cited by 6 publications

(5 citation statements)

References 59 publications

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“…Several studies have evidenced the involvement of the dopaminergic system in SID. Both dopaminergic neuron lesions and the administration of dopamine antagonists—haloperidol, clozapine and pimozide—reduced already acquired SID and affected SID development (Didriksen et al 1993 ; Mittleman et al 1994 ; Mittleman and Valenstein 1986 ; Snodgrass and Allen 1989 ), whereas the dopamine D2/3 receptors agonist quinpirole increased this nonregulatory drinking behaviour in rats (Schepisi et al 2014 ). It has been also demonstrated that high drinker rats showed higher dopamine D2 receptor binding than low drinkers in the SID procedure (Pellón et al 2011 ).…”

Section: Discussionmentioning

confidence: 99%

Chronic ∆-9-tetrahydrocannabinol administration delays acquisition of schedule-induced drinking in rats and retains long-lasting effects

et al. 2021

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Rationale Schedule-induced drinking (SID) is a behavioural phenomenon characterized by an excessive and repetitive drinking pattern with a distinctive temporal distribution that has been proposed as a robust and replicable animal model of compulsivity. Despite cannabis currently being the most widely consumed illicit drug, with growing interest in its clinical applications, little is known about the effects of ∆-9-tetrahydrocannabinol (THC) on SID. Objectives The effects of chronic and acute THC administration on SID acquisition, maintenance and extinction were studied, as were the effects of such administrations on the distinctive temporal distribution pattern of SID. Methods THC (5 mg/kg i.p.), or the corresponding vehicle, was administered to adult Wistar rats for 14 days in a row. Subsequently, THC effects on SID acquisition were tested during 21 sessions using a 1-h fixed-time 60-s food delivery schedule. Acute effects of THC were also evaluated after SID development. Finally, two extinction sessions were conducted to assess behavioural persistence. Results The results showed that previous chronic THC treatment delayed SID acquisition and altered the distinctive behavioural temporal distribution pattern during sessions. Moreover, acute THC administration after SID development decreased SID performance in animals chronically pre-treated with the drug. No great persistence effects were observed during extinction in animals pre-treated with THC. Conclusions These results suggest that chronic THC affects SID development, confirming that it can disrupt learning, possibly causing alterations in time estimation, and also leads to animals being sensitized when they are re-exposed to the drug after long periods without drug exposure.

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Section: Discussionmentioning

confidence: 99%

Chronic ∆-9-tetrahydrocannabinol administration delays acquisition of schedule-induced drinking in rats and retains long-lasting effects

et al. 2021

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“…The precise quantification of the temporal distribution of ILI's may be broadly informative to numerous areas of research including addiction (Barkley‐Levenson and Crabbe, 2012, 2015; Eastwood et al, 2014; Robinson and McCool, 2015), mental illness (Hartfield et al, 2003; Galistu et al, 2011; Schepisi et al, 2014) and aging (Zhang et al, 2008). However, the use of licking microstructure is perhaps most readily translatable for animals models of obesity.…”

Section: Relevance For Study Of Obesity In Animal Modelsmentioning

confidence: 99%

Characterizing ingestive behavior through licking microstructure: Underlying neurobiology and its use in the study of obesity in animal models

Johnson

2017

Intl J of Devlp Neuroscience

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Ingestive behavior is controlled by multiple distinct peripheral and central physiological mechanisms that ultimately determine whether a particular food should be accepted or avoided. As rodents consume a fluid they display stereotyped rhythmic tongue movements, and by analyzing the temporal distribution of pauses of licking, it is possible through analyses of licking microstructure to uncover dissociable evaluative and motivational variables that contribute to ingestive behavior. The mean number of licks occurring within each burst of licking (burst and cluster size) reflects the palatability of the consumed solution, whereas the frequency of initiating novel bouts of licking behavior (burst and cluster number) is dependent upon the degree of gastrointestinal inhibition that accrues through continued fluid ingestion. This review describes the analysis of these measures within a context of the behavioral variables that come to influence the acceptance or avoidance of a fluid, and the neurobiological mechanisms that underlie alterations in the temporal distribution of pauses of licks. The application of these studies to models of obesity in animals is also described.

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“…13) To explain the development of psychogenic polydipsia in schizophrenia, in an animal model, repeated treatment with D2/D3 agonist quinpirole was shown to induce hyperdipsia 14) in a compulsive manner. 15) Many of the behavioral abnormalities seen in BD may be related to hyperdopaminergic activity, 16) especially in the mesolimbic pathway, 17) which might constitute the basis for hyperdipsia in BD as well. In agreement with this, all of our patients responded to antipsychotic drugs.…”

Section: Discussionmentioning

confidence: 99%

Polydipsia as a Precursor of Manic Episode in Bipolar Affective Disorder Patients with Alcohol Use Disorder

Ceylan

Ünsalver

Evrensel

2018

Clin Psychopharmacol Neurosci

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Bipolar affective disorder (BD) diagnosis and initiation of appropriate treatment are often delayed, and this is associated with poorer outcomes, such as rapid cycling or cognitive decline. Therefore, identifying certain warning signs of a probable successive episode during the inter-episode phase is important for early intervention. We present the retrospective data of three cases of BD. Our first case had a history of alcohol use disorder (AUD), where he drank in a dipsomaniac manner, and the other two cases had dipsomaniac alcohol use before their manic attacks, and none of them had any AUD after the mood episode was over. Two brothers also had hypertensive episodes during the manic attacks. None of the cases reported increased fluid intake when they were euthymic. We suggest that polydipsia in BD may be a warning sign of an upcoming manic episode, especially in those patients with AUD. Polydipsia in BD may be caused or facilitated by a combination of hyperdopaminergic activity, hypothalamic dysfunction, and dysregulated renin-angiotensin system. To be able to prevent new episodes, a patient’s drinking habits and change in fluid intake should be asked at every visit. Those patients with a history of alcohol abuse should especially be informed about polydipsia and manic episode association.

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Differences in the structure of drinking, cart expression and dopamine turnover between polydipsic and non polydipsic rats in the quinpirole model of psychotic polydipsia

Abstract: Microstructure analysis confirms that QNP acts on the appetitive component of drinking behavior, making it compulsive. CART expression reduction in response to dopaminergic hyperstimulation might sustain excessive drinking in PD rats.

Cited by 6 publications

References 59 publications

Chronic ∆-9-tetrahydrocannabinol administration delays acquisition of schedule-induced drinking in rats and retains long-lasting effects

Chronic ∆-9-tetrahydrocannabinol administration delays acquisition of schedule-induced drinking in rats and retains long-lasting effects

Characterizing ingestive behavior through licking microstructure: Underlying neurobiology and its use in the study of obesity in animal models

Polydipsia as a Precursor of Manic Episode in Bipolar Affective Disorder Patients with Alcohol Use Disorder

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