Differences in the transcriptional responses induced by Theileria annulata infection in bovine monocytes derived from resistant and susceptible cattle breeds

Jensen, Kirsty; Paxton, Edith; Waddington, David; Talbot, Richard; Darghouth, Mohamed Aziz; Glass, Elizabeth J.

doi:10.1016/j.ijpara.2007.08.007

Cited by 57 publications

(66 citation statements)

References 38 publications

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“…Tick-borne diseases have a major impact on cattle farming affecting 80% of the world's cattle population (Jensen et al 2008). Tropical theileriosis caused by the protozoan parasite T. annulata transmitted by ixodid ticks of the genus Hyalomma seriously affects cattle (d 'Oliveira et al 1997).…”

Section: Discussionmentioning

confidence: 99%

Detection of Theileria annulata by the PCR-RFLP in ticks (Acari, Ixodidae) collected from cattle in West and North-West Iran

Tavassoli

Tabatabaei

Nejad

et al. 2011

Acta Parasitologica

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The presence of potential vectors, ticks, and susceptible hosts of bovine malignant theileriosis in all parts of Iran pose a real threat to food animal industry. The present study was conducted to determine the infection rate of ticks collected from naturally occurring bovine theileriosis in West and North-West Iran. Two hundred and thirty seven cattle suspected of suffering from theileriosis were investigated for the presence of Theileria annulata in the blood smears and any tick species on their body. In this study, 402 ticks were obtained from 99 cattle. The examination of 402 ticks by polymerase chain reaction (PCR) using primers derived from the gene encoding heat shock protein70 (Hsp70) revealed that 39.9% of Hyalomma anatolicum anatolicum, 3.5% of H. asiaticum asiaticum, and 18.2% H. anatolicum excavatum, were infected with T. annulata. The results suggest that H. a. anatolicum may play a major role in transmission of T. annulata infection in Iran. Finally, digestion of the PCR products of T. annulata with two different restriction enzymes produced only a single pattern.

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Section: Discussionmentioning

confidence: 99%

Detection of Theileria annulata by the PCR-RFLP in ticks (Acari, Ixodidae) collected from cattle in West and North-West Iran

Tavassoli

Tabatabaei

Nejad

et al. 2011

Acta Parasitologica

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“…This observation can impact on the overall prevalence of bovine tuberculosis in cattle in Ethiopia because, to improve the nutrition of its population, the Ethiopian government is endeavouring to increase milk production by 40% with a breeding programme to increase the number of exotic (Holstein) dairy cattle that produce more milk than indigenous breeds. We hypothesised that our observations (Ameni et al 2007(Ameni et al , 2008 are due to either differences in the innate immune responses, in particular responses of monocytes or macrophages (described for bovine theileriosis by Jensen et al 2008), in differences in downstream acquired immune responses, or differences in nonimmune processes as described for bovine trypanosomiasis (Naessens et al 2002). To test whether bovine macrophages from uninfected Holstein or zebu cattle respond with a different cytokine profile to mycobacterial infection, monocytes from naïve Holstein and zebu cows (Sahiwal breed) were infected in vitro with Mycobacterium tuberculosis or Mycobacterium bovis and the cytokine profile determined.…”

Section: Introductionmentioning

confidence: 99%

Cytokine responses of Holstein and Sahiwal zebu derived monocytes after mycobacterial infection

Vordermeier

Ameni

Glass

2011

Trop Anim Health Prod

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Recently, we found that Holstein cattle (Bos taurus taurus) displayed higher skin test prevalence and disease severity compared to zebu (Bos taurus indicus) herd-mates kept under identical husbandry conditions in Ethiopia. To determine whether these susceptibility differences were patent at the level of the innate immune system, we infected monocytes from naïve Holstein or Sahiwal zebu cattle with either live virulent Mycobacterium tuberculosis or Mycobacterium bovis. The cytokine profile following infection was compared between the two breeds by measuring IL-1α, IL-6, IL-10, IL-12 and TNF-α as well as nitric oxide in culture supernatants. Our results suggested subtle differences in the cytokine profile because only infection-induced IL-6 production was significantly increased in monocytes from the more susceptible Holstein cattle.

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“…Microarray technology is one such approach that can produce detailed information on gene expression and has been used to dissect pathological processes in parasitic infections (29,36,72). In the context of genetic variation and parasite infections, several studies have concentrated on differences between hosts that are susceptible or tolerant to a particular parasite.…”

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confidence: 99%

Role for Parasite Genetic Diversity in Differential Host Responses toTrypanosoma bruceiInfection

et al. 2010

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The postgenomic era has revolutionized approaches to defining host-pathogen interactions and the investigation of the influence of genetic variation in either protagonist upon infection outcome. We analyzed pathology induced by infection with two genetically distinct Trypanosoma brucei strains and found that pathogenesis is partly strain specific, involving distinct host mechanisms. Infections of BALB/c mice with one strain (927) resulted in more severe anemia and greater erythropoietin production compared to infections with the second strain (247), which, contrastingly, produced greater splenomegaly and reticulocytosis. Plasma interleukin-10 (IL-10) and gamma interferon levels were significantly higher in strain 927-infected mice, whereas IL-12 was higher in strain 247-infected mice. To define mechanisms underlying these differences, expression microarray analysis of host genes in the spleen at day 10 postinfection was undertaken. Rank product analysis (RPA) showed that 40% of the significantly differentially expressed genes were specific to infection with one or the other trypanosome strain. RPA and pathway analysis identified LXR/RXR signaling, IL-10 signaling, and alternative macrophage activation as the most significantly differentially activated host processes. These data suggest that innate immune response modulation is a key determinant in trypanosome infections, the pattern of which can vary, dependent upon the trypanosome strain. This strongly suggests that a parasite genetic component is responsible for causing disease in the host. Our understanding of trypanosome infections is largely based on studies involving single parasite strains, and our results suggest that an integrated host-parasite approach is required for future studies on trypanosome pathogenesis. Furthermore, it is necessary to incorporate parasite variation into both experimental systems and models of pathogenesis.

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Differences in the transcriptional responses induced by Theileria annulata infection in bovine monocytes derived from resistant and susceptible cattle breeds

Cited by 57 publications

References 38 publications

Detection of Theileria annulata by the PCR-RFLP in ticks (Acari, Ixodidae) collected from cattle in West and North-West Iran

Detection of Theileria annulata by the PCR-RFLP in ticks (Acari, Ixodidae) collected from cattle in West and North-West Iran

Cytokine responses of Holstein and Sahiwal zebu derived monocytes after mycobacterial infection

Role for Parasite Genetic Diversity in Differential Host Responses toTrypanosoma bruceiInfection

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