Differences of serum interleukin-6 levels in normotensive and preeclampsia women

Abstract

Red cell distribution width (RDW) has been shown higher with the increase of inflammatory activity. As CD4 count is not available in all cities in Indonesia, RDW was hoped to be the next promising marker to predict the progression of HIV infection. This study aims to find the association of RDW with aCD4 count in HIV-positive reproductive women in Indonesia. It was a prospective cross sectional study enrolled 37 consented outpatients HIV-positive reproductive women in Haji Adam Malik General Hospital, Medan, Indonesia. A 10 mL blood was taken, separated into two tubes for complete blood count and CD4 count. Data were collected and analyzed with SPSS 19.Mean CD4 absolute was lowest in >14.5% RDW group but without statistical significance. By classify CD4 absolute count, CD4 absolute ≤350/mm3 showed significantly higher RDW than CD4 absolute >350/mm3 (13.98±2.10% vs 12.79±0.88%; p=0.02). No correlation was between RDW and CD4 absolute, as well as, with CD4%.In conclusion, high RDW can be a promising marker to predict the low CD4 count in HIV-positive reproductive women within antiretroviral therapy.

Study of Preeclampsia in Placenta, Kidney, and Hepatic Diseases

“…IL-17 and podocyte levels also had a positive association in serum and overreaction of microRNA-155 (miR-155) in PE patients, thus results in increased IL-17 production by CD4 + T-cells in vitro, and decreased nephrin expression in podocytes and apoptotic processes of podocytes [47]. In addition, high red cell distribution width can be a promising marker to predict low CD4 cell counts in HIV-positive reproductive women in antiretroviral therapy in PE women [48]. The effects of adiponectin on the cardiovascular system in hypertensive patients are believed to be partially mediated by activation of 5' active adenosine monophosphate protein kinase and pathway cyclooxygenase-2, reduces endothelial cell apoptosis, promotes the production of nitric oxide, decreased activity in tumor necrosis factoralpha (TNF-α), and prevented atherosclerotic proliferation and smooth muscle cell migration [49].…”