Different expression and localization of aquaporin 7 and aquaporin 9 in granulosa cells, oocytes, and embryos of patients with polycystic ovary syndrome and the negatively correlated relationship with insulin regulation

Song, Wenyan; Wang, Yuan; Hou, Xiao-Man; Tian, Chengcheng; Wu, Liang; Jin, Haixia; Yao, Guidong; Sun, Yingpu

doi:10.1016/j.fertnstert.2020.08.015

Cited by 11 publications

(6 citation statements)

References 38 publications

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“…Despite the still doubtful applicability of AQP9 as a clinical biomarker, few studies have debated its altered expression in both female and male infertility and pregnancy complications (see [ 113 ] for review). For example, in polycystic ovary syndrome (PCOS), decreased AQP9 expression in the granulosa cells was associated with hyperandrogenism [ 114 , 115 ], influencing the maturation of PCOS follicles [ 115 ]. In gestational diabetes mellitus, placentas from cesarean delivery at term showed higher expression of AQP9 compared to normal placentas [ 116 ].…”

Section: Potential Relevance Of Aqp9 As Clinical Biomarkermentioning

confidence: 99%

The Multifaceted Role of Aquaporin-9 in Health and Its Potential as a Clinical Biomarker

et al. 2022

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Aquaporins (AQPs) are transmembrane channels essential for water, energy, and redox homeostasis, with proven involvement in a variety of pathophysiological conditions such as edema, glaucoma, nephrogenic diabetes insipidus, oxidative stress, sepsis, cancer, and metabolic dysfunctions. The 13 AQPs present in humans are widely distributed in all body districts, drawing cell lineage-specific expression patterns closely related to cell native functions. Compelling evidence indicates that AQPs are proteins with great potential as biomarkers and targets for therapeutic intervention. Aquaporin-9 (AQP9) is the most expressed in the liver, with implications in general metabolic and redox balance due to its aquaglyceroporin and peroxiporin activities, facilitating glycerol and hydrogen peroxide (H2O2) diffusion across membranes. AQP9 is also expressed in other tissues, and their altered expression is described in several human diseases, such as liver injury, inflammation, cancer, infertility, and immune disorders. The present review compiles the current knowledge of AQP9 implication in diseases and highlights its potential as a new biomarker for diagnosis and prognosis in clinical medicine.

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Section: Potential Relevance Of Aqp9 As Clinical Biomarkermentioning

confidence: 99%

The Multifaceted Role of Aquaporin-9 in Health and Its Potential as a Clinical Biomarker

et al. 2022

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“…In pig [ 60 ] and cattle oocytes [ 61 ], only the expression of AQP3 mRNA has been explored and confirmed to date. Human oocytes have been reported to express AQP3 and AQP7 mRNAs [ 59 ], although not only the presence of AQP7 protein but also that of AQP9 in germinal vesicle- and MII-oocytes has been confirmed [ 62 ]. In addition, Zhang et al detected the expression of AQP1 , AQP2 and AQP11 mRNAs and their corresponding proteins in human oocytes [ 58 ].…”

Section: Aquaporins In Mammalian Oocytesmentioning

confidence: 99%

Relevance of Aquaporins for Gamete Function and Cryopreservation

Delgado-Bermúdez

Ribas-Maynou

Yeste

2022

Animals

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The interaction between cells and the extracellular medium is of great importance, and drastic changes in extracellular solute concentrations drive water movement across the plasma membrane. Aquaporins (AQPs) are a family of transmembrane channels that allow the transport of water and small solutes across cell membranes. Different members of this family have been identified in gametes. In sperm, they are relevant to osmoadaptation after entering the female reproductive tract, which is crucial for sperm motility activation and capacitation and, thus, for their fertilizing ability. In addition, they are relevant during the cryopreservation process, since some members of this family are also permeable to glycerol, one of the most frequently used cryoprotective agents in livestock. Regarding oocytes, AQPs are very important in their maturation but also during cryopreservation. Further research to define the exact sets of AQPs that are present in oocytes from different species is needed, since the available literature envisages certain AQPs and their roles but does not provide complete information on the whole set of AQPs. This is of considerable importance because, in sperm, specific AQPs are known to compensate the role of non-functional members.

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“…Androgens over-recruited sinus follicles promote granulosa cells to secrete AMH and other follicle growth inhibitory factors through the interaction between follicles, reduce the sensitivity of follicles to FSH, and then prevent the continuous growth, development and maturation of follicles [31]. Third, aquaporin-9 (AQP9) is involved in the development and maturation of follicles through the transport of water and hormones, which increases the volume of dominant follicles and the follicular uid signi cantly [32]. The high androgens environment in the follicular uid of PCOS patients inhibits the expression of AQP9 in granulosa cells through the phosphatidylinositol 3 kinase pathway, thereby prevents follicular maturation and ovulation [33].…”

Section: Discussionmentioning

confidence: 99%

Follicular development and endometrial receptivity of different androgen phenotypes in polycystic ovary syndrome

Wang,

Bai,

Wang

2024

Preprint

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Objective The study was conducted to explore the follicular development and endometrial receptivity of different androgen phenotypes in reproductive-aged patients with PCOS. Methods Two hundred and sixty-eight polycystic ovary syndrome (PCOS) patients with infertility were recruited and divided into two groups according to different androgen phenotypes in this study: abnormal menstruation and hyperandrogenism (AM-HA group, n = 127), abnormal menstruation and polycystic ovarian morphology (AM-PCOM group, n = 141). The follicular development, endometrial receptivity and pregnancy rates of natural cycle between the two groups were compared. Results The number of dominant follicle, number of ovulation, and normal ovulation rate in AM-HA group were significantly lower compared with AM-PCOM group (P < 0.05). The endometrial thickness (ET), endometrial volume (EV), vascularization index (VI), flow index (FI) and vascularization flow index (VFI) on days from 14 to 24 of the menstrual cycle were significantly lower in AM-HA group than in AM-PCOM group (P < 0.05). The endometrial VI, FI and VFI, the integrin αvβ3 and VEGF concentrations in uterine fluid during implantation window were significantly lower in AM-HA group compared with AM-PCOM group (P < 0.05). However, no statistically significant differences were observed in uterine artery blood flow parameters, ET and EV between the two groups (P > 0.05). The biochemical pregnancy rate, clinical pregnancy rate and ongoing pregnancy rate in AM-HA group were significantly lower than in AM-PCOM group (P < 0.05). Conclusion The phenotype of AM-HA in PCOS patients was vulnerable to ovulation disorder and impaired endometrial receptivity, which resulted in reduced pregnancy rate. Treatment of HA is likely to become an effective approach for improving endometrial receptivity and fecundity disorders in patients with PCOS.

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Different expression and localization of aquaporin 7 and aquaporin 9 in granulosa cells, oocytes, and embryos of patients with polycystic ovary syndrome and the negatively correlated relationship with insulin regulation

Cited by 11 publications

References 38 publications

The Multifaceted Role of Aquaporin-9 in Health and Its Potential as a Clinical Biomarker

The Multifaceted Role of Aquaporin-9 in Health and Its Potential as a Clinical Biomarker

Relevance of Aquaporins for Gamete Function and Cryopreservation

Follicular development and endometrial receptivity of different androgen phenotypes in polycystic ovary syndrome

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