Different expression levels of α3/4 fucosyltransferases and Lewis determinants in ovarian carcinoma tissues and cell lines

Escrevente, Cristina; Machado, Eda; Brito, Catarina; Reis, Celso A.; Stoeck, Alexander; Runz, Steffen; Marmé, Alexander; Altevogt, Peter; Costa, Nascimento

doi:10.3892/ijo.29.3.557

Cited by 39 publications

(43 citation statements)

References 19 publications

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“…LeY is a difucosylated oligosaccharide, which is overexpressed in the majority of carcinomas (Cao et al, 2001;Escrevente et al, 2006)4and has the following chemical structure: [Fucα14 2Galβ14 4(Fucα14 3) GlcNAcβ14 R]. Arai (Arai & Nishida, 2003), and Skovlund (1997) showed that LeY is highly expressed in endometrial cancer and related to tumor grade.…”

Section: Fucosyltransferase IV Enhances Expression Of Mmp-12 Stimulatmentioning

confidence: 99%

Fucosyltransferase IV Enhances Expression of MMP-12 Stimulated by EGF via the ERK1/2, p38 and NF-kB Pathways in A431Cells

Yang¹,

Liu²,

Liu³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Section: Fucosyltransferase IV Enhances Expression Of Mmp-12 Stimulatmentioning

confidence: 99%

Fucosyltransferase IV Enhances Expression of MMP-12 Stimulated by EGF via the ERK1/2, p38 and NF-kB Pathways in A431Cells

Yang¹,

Liu²,

Liu³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…3D). Interestingly, Western blot analysis of LOX cells stained with HPA revealed four to five major bands, in contrast to LSC and LS174T Tn+ cells, both of which displayed a large molecular weight distribution of HPA-positive 9 Unpublished result.…”

Section: Lsc Cells Lacking T-synthase Activity Contain Mutatedmentioning

confidence: 99%

“…According to the predicted promoter sequence obtained from the online promoter analysis software, 8 two CpG islands (CpG-I and CpG-II) reside upstream from the coding sequence. From the available human EST and the Cosmc transcript size analyzed using Northern blot analysis, 9 the Cosmc transcript likely begins within the CpG-II, which contains four Sp1 sites (specific transcription activator site), suggesting that the CpG-II may serve as a promoter for this gene. Interestingly, LOX cells exhibited a genomic deletion of this CpG-II sequence, although FEMX-I cells exhibited a normal CpG-II sequence.…”

Section: Lsc Cells Lacking T-synthase Activity Contain Mutatedmentioning

confidence: 99%

“…However, little is known about the mechanisms controlling expression of Tn and STn. The expression of TACAs has been proposed to result from altered metabolism of tumor cells, changes in the tumor microenvironment, and consequent changes in expression of multiple genes within the glycosylation pathways (8)(9)(10). No specific genetic mutations have been found in glycosylation pathways in human tumor cells to explain the expression of these TACAs.…”

Section: Introductionmentioning

confidence: 99%

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Human Tumor Antigens Tn and Sialyl Tn Arise from Mutations inCosmc

Lanneau

Gautam³

et al. 2008

Cancer Research

253

266

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Neoplastic lesions typically express specific carbohydrate antigens on glycolipids, mucins, and other glycoproteins. Such antigens are often under epigenetic control and are subject to reversion and loss upon therapeutic selective pressure. We report here that two of the most common tumor-associated carbohydrate antigens, Tn and sialyl Tn (STn), result from somatic mutations in the gene Cosmc that encodes a molecular chaperone required for formation of the active T-synthase. Diverse neoplastic lesions, including colon cancer and melanoma-derived cells lines, expressed both Tn and STn antigen due to loss-of-function mutations in Cosmc. In addition, two human cervical cancer specimens that showed expression of the Tn/STn antigens were also found to have mutations in Cosmc and loss of heterozygosity for the cross-linked Cosmc locus. This is the first example of somatic mutations in multiple types of cancers that cause global alterations in cell surface carbohydrate antigen expression. [Cancer Res 2008;68(6):1636-46]

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“…In addition, FUT4 is known to associate with other factors of malignancy such as metastasis [8]. Among FUT4 catalyzed fucosylated oligosaccharide antigens, LeY expression correlates with tumor proliferation, invasion and metastasis in carcinomas of breast, cervix, and ovary [4,[22][23][24]. Although a few studies have shown that sLeX and sLea act as selectin ligands that can mediate carcinoma metastasis [25][26], there is no direct evidence showing that the binding of LeY and selectins mediates a similar process.…”

Section: Discussionmentioning

confidence: 99%

Differential fucosyltransferase IV expression in squamous carcinoma cells is regulated by promoter methylation

Li¹,

Tong²,

Liu

et al. 2012

Cellular and Molecular Biology Letters

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Enhanced fucosyltransferase IV (FUT4) expression correlates with increased tumor malignancy in many carcinomas. However, little is known about the regulation of FUT4 expression, and whether FUT4 expression is influenced by the methylation status of the FUT4 promoter is unclear. In this study, we demonstrated that FUT4 expression is negatively correlated with the methylation degree of a CpG island in the FUT4 promoter, suggesting that the methylation status of FUT4 promoter regulates the expression of FUT4. The results indicate that manipulating the methylation status of the FUT4 promoter to regulate FUT4 expression may be a novel approach in the treatment of malignant tumors.

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Different expression levels of α3/4 fucosyltransferases and Lewis determinants in ovarian carcinoma tissues and cell lines

Cited by 39 publications

References 19 publications

Fucosyltransferase IV Enhances Expression of MMP-12 Stimulated by EGF via the ERK1/2, p38 and NF-kB Pathways in A431Cells

Fucosyltransferase IV Enhances Expression of MMP-12 Stimulated by EGF via the ERK1/2, p38 and NF-kB Pathways in A431Cells

Human Tumor Antigens Tn and Sialyl Tn Arise from Mutations inCosmc

Differential fucosyltransferase IV expression in squamous carcinoma cells is regulated by promoter methylation

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