Different histologic patterns of cutaneous granulomas in systemic lymphoma

Rongioletti, Franco; Cerroni, Lorenzo; Massone, Cesare; Basso, Matteo; Ciambellotti, A.; Rebora, Alfredo

doi:10.1016/j.jaad.2004.02.024

Cited by 56 publications

(33 citation statements)

References 21 publications

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“…Some consider it as peculiar hypersensitivity response to malignant cells or some persistent infection while some consider it as protective phenomenon with good prognosis. [10][11][12] Prognostic significance of granulomas in the setting of malignant disease is not clear though some may consider it as protective response of host. Granuloma does not necessarily mean better prognosis as four patients of GMF who died of disseminated disease have been reported.…”

Section: Discussionmentioning

confidence: 99%

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Granulomatous mycosis fungoides with hypohidrosis mimicking lepromatous leprosy

Gutte¹,

Kharkar²,

Mahajan³

et al. 2010

Indian J Dermatol Venereol Leprol

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Granulomatous mycosis fungoides (GMF) is a rare type of cutaneous T cell lymphoma. A 38-year-old married male presented with decreased sweating all over the body for last 8 years, progressive redness and scaling over body for 2 years and multiple noduloulcerative lesions over the body for 1 year. Cutaneous examination revealed generalized erythema and scaling with poikilodermatous changes over chest and upper back along with multiple noduloulcerative lesions. Skin biopsy from a nodular lesion revealed dense granulomatous infiltrate of atypical lymphocytes with epidermotropism and sparing of appendages. Diagnosis of GMF was made. Computed tomographic scan of thorax, abdomen and pelvis revealed axillary and inguinal lymphadenopathy. Immunohistochemistry revealed leukocyte common antigen and CD3 positivity suggestive of T cell origin. Patient was started on CHOP (Cyclophosphamide, Hydroxydaunorubicin, Oncovin and Prednisolone) regimen of chemotherapy with marked improvement after three cycles of chemotherapy. This case had some clinical resemblance to lepromatous leprosy.

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Section: Discussionmentioning

confidence: 99%

“…Granuloma does not necessarily mean better prognosis as four patients of GMF who died of disseminated disease have been reported. [4,11] A case with spontaneous regression of GMF in HIV positive patient has also been described. Regression was thought to be probably due to cytotoxic effect of HIV on neoplastic cells.…”

Section: Discussionmentioning

confidence: 99%

Granulomatous mycosis fungoides with hypohidrosis mimicking lepromatous leprosy

Gutte¹,

Kharkar²,

Mahajan³

et al. 2010

Indian J Dermatol Venereol Leprol

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show abstract

“…The second type consists of GA-like skin processes or sarcoidlike granulomas that are a nonspecific manifestation of the underlying lymphoma. 12 Skin lesions with noninfectious epithelioid granulomatous changes have previously been described in a few patients with ATL. [13][14][15] Some authors have argued that such a granulomatous reaction might be a protective host response against the progression of ATL.…”

Section: Discussionmentioning

confidence: 99%

Granuloma annulare-like skin lesions as an initial manifestation in a Japanese patient with adult T-cell leukemia/lymphoma

Kawakami

Kawanabe

Soma

2009

Journal of the American Academy of Dermatology

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“…The first type is associated with specific lymphomatous lesions, a situation reminiscent of some subsets of cutaneous T-cell lymphoma, which may show a granulomalous pattern with or without the particular slack skin clinical picture (5); in this setting, neoplastic cells are admixed with histiocytes and the occurrence of a granuloma tnight represent a reactive pattern against tumoural cells. The second type is a non-specific granulomatous reaction without any neoplastic cells, and different histological patterns have been described, such as sarcoidosis-like, granuloma annulare-like and tuberculoid granuloma (6,7). The dominant histological picture seems to be the sarcoidosis-like pattern, more particularly reported in association with Hodgkin's disease in a significant number of cases.…”

Section: Discussionmentioning

confidence: 99%