Different HLA class II (DRB1 and DQB1) alleles determine either susceptibility or resistance to NMO and multiple sclerosis among the French Afro-Caribbean population

Abstract

In conclusion, comparison of the HLA-DRB1 and DQB1 distribution in NMO and MS in this Afro-Caribbean population shows important differences in the HLA associations among NMO and MS.

Distinct genetic and infectious profiles in Japanese neuromyelitis optica patients according to anti-aquaporin 4 antibody status

“…These observations are partially consistent with the previous finding that anti-AQP4 antibody is associated with frequent relapses 8. Therefore, it is conceivable that the pathogenic mechanisms underlying anti-AQP4 antibody positive NMO/NMOSD may differ from those underlying the anti-AQP4 antibody negative type, and that development of AQP4 autoimmunity is in part based on genetic background (in Asians by DPB1*0501 and DRB1*1602 and in Caucasians by other HLA class II genes, such as DRB1*03 ) 29 30…”

Genetic and environmental backgrounds responsible for the changes in the phenotype of MS in Japanese subjects

“…Even after the discovery of NMO-IgG, the DPB1*0501 allele was shown to be associated with NMO-IgG/anti-AQP4 antibody positivity in Japanese and Southern Han Chinese (Wang et al, 2011a). In Caucasians, HLA class II gene alleles other than DRB1*1501, such as DRB1*03, have also been shown to be risk alleles for NMO (Brum et al, 2010;Deschamps et al, 2011). These observations reinforce the notion that susceptibility to each clinical phenotype, CMS or OSMS/NMO, is partly genetically determined.…”

The immunogenetics of neurological disease

“…68,69 Meanwhile, in contrast to Asian populations, 69 DPB1*05:01 revealed no association with NMO in a French population, but DRB1*03 was shown to be a susceptibility marker. 66,67,72 Similarly, DRB1*03 has been also observed with increased risks for NMO among Brazilian mulattos, 73 Afro-Caribbeans 74 and Mexican Mestizos, 75 but not in Muslim Arabs. 76 It is important to consider that as DRB1*03 is comparatively less frequent and DPB1*05:01 is more frequent in Asian population, there may be inadequate power to detect the risk for DRB1*03 in Asian populations and DPB1*05:01 in European populations, yielding these varied results.…”