Different metabolic responses to exercise training programmes in single rat muscle fibres

Takekura, Hiroaki; Yoshioka, Toshitada

doi:10.1007/bf01766489

Cited by 21 publications

(15 citation statements)

References 40 publications

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“…Additional research on contractile force and speed of contraction in relation to muscle fiber types has been conducted on single fibers [8,9,17,18]. Specifically, it has been previously demonstrated that pressure curve profiles from groups of muscles can be interpreted and related to specific fiber types [10,11,19,20], Thus, the changes in profiles over time in this study may be interpreted similarly to those examined by Laycock and Jerwood [12].…”

Section: Discussionsupporting

confidence: 54%

Pelvic muscle profile types in response to pelvic muscle exercise

1995

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Abstract:The purpose of this research was to describe the contractile response of pelvic muscle to exercise (PME). Pelvic muscle pressure curves from ten randomly selected records from a larger study of 65 women with urodynamically demonstrated stress urinary incontinence (SUI) were analyzed. The subjects completed a PME protocol that lasted 16 weeks. Five pressure curves before and after 16 weeks of exercise were analyzed and classified according to pressure-time profile types. Descriptive statistics revealed decreases in urine loss variables and increases in pelvic muscle pressure curve variables. Changes in profile characteristics suggested an increase in type II muscle fiber recruitment; recruitment of type I fibers that appeared less fatigable; and increased contractile force of both type I and type II fibers. Changes were analyzed by descriptive statistics and by reference to putative types. Reference to profile types may be useful to PME prescription to enhance fiber type-specific performance.

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Section: Discussionsupporting

confidence: 54%

Pelvic muscle profile types in response to pelvic muscle exercise

1995

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“…It has previously been reported that the optimal training intensity varies among different fiber types and that improvements in oxidative capacity (cytochrome c activity) can be reduced with increases in training intensity (19). Furthermore, previous studies incorporating more moderate-intensity treadmill training in rats have reported significant increases in the CS of the EDL muscle (47,50). Regardless of the explanation, our results suggest that high-intensity interval training can lead to a decrease in the mitochondrial mass of the EDL (a predominantly fast-twitch fiber), as indicated by the significantly lower CS activity in the EDL of trained rats.…”

Section: Adaptations To the Edlmentioning

confidence: 95%

Sodium bicarbonate ingestion prior to training improves mitochondrial adaptations in rats

Bishop

Thomas

Moore-Morris

et al. 2010

American Journal of Physiology-Endocrinology and Metabolism

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We tested the hypothesis that reducing hydrogen ion accumulation during training would result in greater improvements in muscle oxidative capacity and time to exhaustion (TTE). Male Wistar rats were randomly assigned to one of three groups (CON, PLA, and BIC). CON served as a sedentary control, whereas PLA ingested water and BIC ingested sodium bicarbonate 30 min prior to every training session. Training consisted of seven to twelve 2-min intervals performed five times/wk for 5 wk. Following training, TTE was significantly greater in BIC (81.2 ± 24.7 min) compared with PLA (53.5 ± 30.4 min), and TTE for both groups was greater than CON (6.5 ± 2.5 min). Fiber respiration was determined in the soleus (SOL) and extensor digitorum longus (EDL), with either pyruvate (Pyr) or palmitoyl carnitine (PC) as substrates. Compared with CON (14.3 ± 2.6 nmol O2·min−1·mg dry wt−1), there was a significantly greater SOL-Pyr state 3 respiration in both PLA (19.6 ± 3.0 nmol O2·min−1·mg dry wt−1) and BIC (24.4 ± 2.8 nmol O2·min−1·mg dry wt−1), with a significantly greater value in BIC. However, state 3 respiration was significantly lower in the EDL from both trained groups compared with CON. These differences remained significant in the SOL, but not the EDL, when respiration was corrected for citrate synthase activity (an indicator of mitochondrial mass). These novel findings suggest that reducing muscle hydrogen ion accumulation during running training is associated with greater improvements in both mitochondrial mass and mitochondrial respiration in the soleus.

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“…With muscle fiber hypertrophy, there is a significant increase in the oxidative enzymes succinate dehydrogenase (SDH) and MDH induced by sprint training and a further increase following endurance training in rat leg muscle [Takekura and Yoshioka, 1990]. This illustrates enzymatic adaptations in the energy-generating machinery of the cell in order to meet the energy needs of increased contractile power.…”

Section: Nadmentioning

confidence: 97%

“…Exercise training has been shown to increase the levels of glycolytic and oxidative enzymes in heart and skeletal muscle [Takekura and Yoshioka, 1990;Stuewe et al, 2000]. With muscle fiber hypertrophy, there is a significant increase in the oxidative enzymes succinate dehydrogenase (SDH) and MDH induced by sprint training and a further increase following endurance training in rat leg muscle [Takekura and Yoshioka, 1990].…”

Section: Nadmentioning

confidence: 99%

Developmental regulation and cellular distribution of human cytosolic malate dehydrogenase (MDH1)

Liew

Ngai

et al. 2004

J of Cellular Biochemistry

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Human cyotsolic malate dehydrogenase (MDH1) is important in transporting NADH equivalents across the mitochondrial membrane, controlling tricarboxylic acid (TCA) cycle pool size and providing contractile function. Cellular localization studies indicate that MDH1 mRNA expression has a strong tissue-specific distribution, being expressed primarily in cardiac and skeletal muscle and in the brain, at intermediate levels in the spleen, kidney, intestine, liver, and testes and at low levels in lung and bone marrow. The observed MDH1 localizations reflect the role of NADH in the support of a variety of functions in different organs. These functions are primarily related to aerobic energy production for muscle contraction, neuronal signal transmission, absorption/resorption functions, collagen-supporting functions, phagocytosis of dead cells, and processes related to gas exchange and cell division. During neonatal development, MDH1 is expressed in human embryonic heart as early as the 3rd month and then is over-expressed from the 5th month until the birth. The expression of MDH1 is maintained in the adult heart but is not present in levels as high as in the fetus. Finally, over-expression of MDH1 is found in left ventricular cardiac muscle of dilated cardiomyopathy (DCM) patients when contrasted to the diseased non-DCM and normal heart muscle by in situ hybridization and Western blot. These observations are compatible with the activation of glucose oxidation in relatively hypoxic environments of fetal and hypertrophied myocardium.

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Different metabolic responses to exercise training programmes in single rat muscle fibres

Cited by 21 publications

References 40 publications

Pelvic muscle profile types in response to pelvic muscle exercise

Pelvic muscle profile types in response to pelvic muscle exercise

Sodium bicarbonate ingestion prior to training improves mitochondrial adaptations in rats

Developmental regulation and cellular distribution of human cytosolic malate dehydrogenase (MDH1)

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