Different molecular weight chitosan derivatives employed for enantiomeric separation

Abstract

The interaction between two single enantiomers in a racemic mixture impacts the chromatographic retention of the enantiomers to different degrees.

Recent development trends for chiral stationary phases based on chitosan derivatives, cyclofructan derivatives and chiral porous materials in high performance liquid chromatography

“…To date, the impact of the molecular weight of cellulose/ amylose on the enantioseparation performance of the corresponding CSPs have been reported in only few studies [37][38][39]. Bai et al have also reported some studies on the relationship between the molecular weight of the chitosan derivatives and their performance, including the chiral recognition ability and mobile phase tolerance of the CSPs [30,32,36,[40][41][42]. Most of these studies indicated that chitosan derivatives with a lower molecular weight showed better enantioseparation performance, but a higher molecular weight was more preferable to tolerate the organic solvents used.…”