2022
DOI: 10.1101/2022.12.10.519892
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Different neuroendocrine cell types in thepars intercerebralisofPeriplaneta americanaproduce their own specific IGF-related peptides

Abstract: Of the nine genes of the American cockroach, Periplaneta americana, coding for peptides related to insulin and insulin-like growth factor, seven show significant expression in the central nervous system as demonstrated by the polymerase chain reaction on reverse transcribed RNA. In situ hybridisation shows that five of those are expressed by cells in the pars intercerebralis. Antisera raised to the predicted peptides show that these cells are neuroendocrine in nature and project to the corpora cardiaca. Intere… Show more

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Cited by 1 publication
(3 citation statements)
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“…As there is no ovary tissue in the head the expression of brovirpin in the head is likely by neuroendocrine cells in the brain. Such a dual expression of a sirp by both the ovary and brain neuroendocrine cells is also observed in the case of Periplaneta sirp 3 (Veenstra, 2023). Brovirpin is also expressed in much larger quantities in female than in male soldiers in Z. nevadensis (Suppl.…”
Section: Expression Of Igf and Sirps And Functionl Relevance Of Atirpinmentioning
confidence: 66%
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“…As there is no ovary tissue in the head the expression of brovirpin in the head is likely by neuroendocrine cells in the brain. Such a dual expression of a sirp by both the ovary and brain neuroendocrine cells is also observed in the case of Periplaneta sirp 3 (Veenstra, 2023). Brovirpin is also expressed in much larger quantities in female than in male soldiers in Z. nevadensis (Suppl.…”
Section: Expression Of Igf and Sirps And Functionl Relevance Of Atirpinmentioning
confidence: 66%
“…Spreadsheet-1). The reads for birpin, cirpin and brovirpin in SRAs from heads or heads and thoraces and the presence of characteristic endocrine convertase cleavages sites in their precursors suggests that these sirps are likely expressed by brain neuroendocrine cells, as is the case for such peptides in other insect species, including the American and German cockroaches (Castro-Arnau et al, 2019;Veenstra, 2023). However, unlike birpin and cirpin, brovirpin is also expressed in the abdomen.…”
Section: Expression Of Igf and Sirps And Functionl Relevance Of Atirpinmentioning
confidence: 98%
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