Different prognostic indices in 310 patients with tonsillar carcinomas

Abstract

Earlier reported TNM-based stage modifications are all very useful predictors of survival in tonsillar carcinomas. In addition, age, gender, total radiation dose, and duration of radiotherapy were important prognostic factors. We propose that both host and treatment factors should be tested carefully when building new prognostic indices in tonsillar carcinomas.

Correlation between reduced expression of the spindle checkpoint protein BubR1 and bad prognosis in tonsillar carcinomas

“…The treatment and prognosis have previously been reported in detail for these 310 patients. 23 Complete follow-up and accurate cause of death were obtained by direct patient knowledge, review of outpatient and hospital charts, autopsy findings, direct contact with local hospitals, family physicians, or in some cases by next of kin. The Norwegian Data Inspectorate and the Regional Ethical Committee of South Norway approved the study.…”

Mcl-1, Vascular Endothelial Growth Factor-R2, and 14-3-3σ Expression Might Predict Primary Response against Radiotherapy and Chemotherapy in Patients with Locally Advanced Squamous Cell Carcinomas of the Head and Neck

“…Patients without evidence of disease or with remaining tumor masses in the primary site and/or locoregional lymph nodes were scored as complete or partial responders, respectively. In the complete responder group, an advanced tumor and lymph node staging (T [3][4] and N 2-3 ) was diagnosed in 97% and 87% of all patients, respectively. In the partial responder group, 100% of all patients had a T [3][4] and N 2-3 staging.…”

“…In the complete responder group, an advanced tumor and lymph node staging (T [3][4] and N 2-3 ) was diagnosed in 97% and 87% of all patients, respectively. In the partial responder group, 100% of all patients had a T [3][4] and N 2-3 staging. Chemotherapy was administered to 21 and 8 patients with complete or partial tumor remission, respectively, and did not affect outcome in a significant manner.…”

“…Although the therapeutic management of head and neck cancer has benefited from small and incremental improvements over the past few years, the management of advanced head and neck tumors continues to principally depend on tumor localization and on tumor stage (2). The tumor-node-metastasis stage alone, however, is not sufficient to stratify patients according to their likeliness to respond against different therapies (3,4). In order to improve treatment outcome, a better understanding of the pathophysiology of head and neck cancer, and the identification of potentially clinically relevant molecular markers for early diagnosis and optimal treatment planning are necessary.…”

Prognostische Wertigkeit der Zeitparameter in der adjuvanten Radiotherapie von HNO–Tumoren

“…Die prognostische Relevanz der Resektionsränder bei HNOwie auch anderen Tumoren wurde mehrfach untersucht und bestätigt [24,34], ebenso die des Geschlechts [12], des NStatus [5] und der Anämie [10,13,14], wobei sich in unserem Kollektiv die unmittelbar postoperative Anämie (Hb < 12 g/dl) als prognostisch entscheidend für alle Endpunkte erwies.…”