Different reactive species modulate the hypotensive effect triggered by angiotensins at CVLM of 2K1C hypertensive rats

Sousa, Graziele Galdino de; Barbosa, Maria Andrea; Barbosa, Claudiane Maria; Lima, Taynara Carolina; Santos, Robson Augusto Souza; Campagnole‐Santos, Maria José; Alzamora, Andréia Carvalho

doi:10.1016/j.peptides.2020.170409

Peptides

2020

DOI: 10.1016/j.peptides.2020.170409

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Different reactive species modulate the hypotensive effect triggered by angiotensins at CVLM of 2K1C hypertensive rats

Graziele Galdino de Sousa

Maria Andrea Barbosa

Claudiane Maria Barbosa

et al.

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2024

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Angiotensin-(1-7) and Central Control of Cardiometabolic Outcomes: Implications for Obesity Hypertension

Vernail,

Lucas,

Miller

et al. 2024

IJMS

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Hypertension is a leading independent risk factor for the development of cardiovascular disease, the leading cause of death globally. Importantly, the prevalence of hypertension is positively correlated with obesity, with obesity-related hypertension being difficult to treat due to a lack of current guidelines in this population as well as limited efficacy and adverse off-target effects of currently available antihypertensive therapeutics. This highlights the need to better understand the mechanisms linking hypertension with obesity to develop optimal therapeutic approaches. In this regard, the renin–angiotensin system, which is dysregulated in both hypertension and obesity, is a prime therapeutic target. While research and therapies have typically focused on the deleterious angiotensin II axis of the renin–angiotensin system, emerging evidence shows that targeting the protective angiotensin-(1-7) axis also improves cardiovascular and metabolic functions in animal models of obesity hypertension. While the precise mechanisms involved remain under investigation, in addition to peripheral actions, evidence exists to support a role for the central nervous system in the beneficial cardiometabolic effects of angiotensin-(1-7). This review will highlight emerging translational studies exploring the cardiovascular and metabolic regulatory actions of angiotensin-(1-7), with an emphasis on its central actions in brain regions including the brainstem and hypothalamus. An improved understanding of the central mechanisms engaged by angiotensin-(1-7) to regulate cardiovascular and metabolic functions may provide insight into the potential of targeting this hormone as a novel therapeutic approach for obesity-related hypertension.

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Angiotensin-(1-7) and Central Control of Cardiometabolic Outcomes: Implications for Obesity Hypertension

Vernail,

Lucas,

Miller

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

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Different reactive species modulate the hypotensive effect triggered by angiotensins at CVLM of 2K1C hypertensive rats

Cited by 1 publication

References 54 publications

Angiotensin-(1-7) and Central Control of Cardiometabolic Outcomes: Implications for Obesity Hypertension

Angiotensin-(1-7) and Central Control of Cardiometabolic Outcomes: Implications for Obesity Hypertension

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