Different-sized black phosphorus nanosheets with good cytocompatibility and high photothermal performance

Fu, Haidi; Li, Zhibin; Xie, Hanhan; Sun, Zhaoyong; Wang, Beike; Huang, Hao; Hân, Gia; Wang, Huaiyu; Chu, Paul K.; Yu, Xue‐Feng

doi:10.1039/c7ra00160f

Cited by 68 publications

(51 citation statements)

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“…By combining both the photothermal effect of AuNP and the tumor targeting and magnetic resonance imaging guiding ability of iron oxide nanoparticles, this platform presents enhanced therapeutic effect. Besides surface modification, it has been demonstrated that the size of BP nanosheets also has an important role in their PTT efficiency 131 . Three different sizes of liquid exfoliated BP nanosheets, namely large BP (~394 nm ± 75 nm), medium BP (~118 nm ± 22 nm) and small BP (~4.5 nm ± 0.6 nm) were used to evaluate their PTT efficiency.…”

Section: Biomedical Applications Of Black Phosphorusmentioning

confidence: 99%

Black Phosphorus and its Biomedical Applications

et al. 2018

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Black phosphorus (BP), also known as phosphorene, has attracted recent scientific attention since its first successful exfoliation in 2014 owing to its unique structure and properties. In particular, its exceptional attributes, such as the excellent optical and mechanical properties, electrical conductivity and electron-transfer capacity, contribute to its increasing demand as an alternative to graphene-based materials in biomedical applications. Although the outlook of this material seems promising, its practical applications are still highly challenging. In this review article, we discuss the unique properties of BP, which make it a potential platform for biomedical applications compared to other 2D materials, including graphene, molybdenum disulphide (MoS2), tungsten diselenide (WSe2) and hexagonal boron nitride (h-BN). We then introduce various synthesis methods of BP and review its latest progress in biomedical applications, such as biosensing, drug delivery, photoacoustic imaging and cancer therapies (i.e., photothermal and photodynamic therapies). Lastly, the existing challenges and future perspective of BP in biomedical applications are briefly discussed.

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Section: Biomedical Applications Of Black Phosphorusmentioning

confidence: 99%

Black Phosphorus and its Biomedical Applications

et al. 2018

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“…Under 808 nm laser irradiation for 10 min, nearly all the C6 (glioma cells) and MCF7 (breast cancer cells) cells incubated with 50 ppm of BPQDs for 4 h were killed ( Figure a,b), significantly indicating the obvious photothermal destruction of BPQDs. BP nanosheets with different sizes have also been studied to evaluate their distinct cytocompatibility and capability of photothermal ablation toward cancer cells . It was shown that BP nanosheets with larger size possessed better photothermal ablation of cancer cells.…”

Section: Biomedical Application Of Nano‐bpmentioning

confidence: 99%

Recent Advances on Black Phosphorus for Biomedicine and Biosensing

Xia

Guo

2019

Adv Funct Materials

201

115

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Black phosphorus nanostructures (nano-BPs) include BP nanosheets, BP quantum dots, and BP nanoparticles. Since first being discovered in 2014, nano-BP has become one of the most popular nanomaterials. Nano-BP has many unique properties, such as excellent surface activity, tunable bandgap, high carrier mobility, moderate on/off ratio, excellent biocompatibility, good biodegradation, etc., all of which make nano-BP particularly attractive in biomedicine and biosensing. This review article comprehensively summarizes recent advances in synthesis, functionalization, biomedicine, and biosensing applications of nano-BP. Different methods are first introduced, such as mechanical cleavage, liquid-phase ultrasonic exfoliation, electrochemical exfoliation, solvothermal treatment, and acoustic-microfluidic stripping, for making the nano-BP. Then two strategies are emphasized to enhance ambient stability of nano-BP, namely physical encapsulation and chemical modification. Next, how to develop nano-BP as advanced imaging agents, nanocarriers, and nanomedicine for bioimaging (fluorescence imaging, thermal imaging, and photoacoustic imaging) and disease treatment (phototherapy and photo/chemical/immune synergistic therapy) is demonstrated. The biosensing applications on nano-BP is introduced, including electrochemical biosensor, fluorescence biosensor, chemiluminescence biosensor, electrogenerated chemiluminescence biosensor, and colorimetric biosensor. Finally, the current challenges and future perspectives on nano-BP in bioapplications are discussed. Nano-BP SynthesisLayered nanomaterials are usually exfoliated from bulk crystals. [35] Compared with bulk materials, monolayer or fewlayer nanomaterials possess the enhanced surface area, excellent physiochemical activity and optoelectronic property. The exfoliation from bulk crystal to monolayer or few-layer nanosheets has been widely applied for preparing almost all the 2D nanomaterials, graphene, MoS 2 , MXene nanosheets, etc. [36] Bulk BP, similar to graphite, is the stacking of layered BP nanosheets via the weak van der Waals force. The destruction of the external driving forces to the weak van der Waals interaction between the stack layers greatly contributes to the exfoliation of nano-BP from the bulk counterparts. Mechanical exfoliation and liquid phase ultrasonic exfoliation are the two most popular approaches, and some other methods were also involved, electrochemical exfoliation and solvothermal treatment, for instance. Table 1 summarizes the advantages and limitations of different exfoliation methods. Mechanical ExfoliationMechanical exfoliation, also called scotch-tape delamination, mainly utilizes the larger binding energy between the substrate and layered materials than van der Waals forces in Figure 2. a) Schematic illustration of meta-assisted mechanical exfoliation for FLBP. b) The left is FLBPs exfoliated using the normal scotch-tape microcleavage, and the right is FLBP exfoliated using Au-assisted method, and c) the total area of FLBP on 10 different samples. ...

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“…[97b] The cytotoxicity of BP nanostructures is also size dependent.F or example,t he cytotoxicity of BP nanostructures prepared by vapor growth is lower than that of GO nanomaterials but higher than that of exfoliated transition metal dichalcogenides (TMD) for mammalianc ells. [106] In general, the concentration-, size-, and cell type-dependentc ytotoxicity of BP nanostructures stems from intracellular reactive oxygen species (ROS) and disruption of cell membranes caused by the interactions between BP and cells. [106] In general, the concentration-, size-, and cell type-dependentc ytotoxicity of BP nanostructures stems from intracellular reactive oxygen species (ROS) and disruption of cell membranes caused by the interactions between BP and cells.…”

Section: Nanoscale Black Phosphorusmentioning

confidence: 99%

“…[105] On the other hand, Fu et al have observed that few-layer BP NPs with sizes of 394 AE 75, 118 AE 22, and 4.5 AE 0.6 nm prepared by vapor growth and exfoliated in DMSO all have excellent biocompatibility for different cell lines. [106] In general, the concentration-, size-, and cell type-dependentc ytotoxicity of BP nanostructures stems from intracellular reactive oxygen species (ROS) and disruption of cell membranes caused by the interactions between BP and cells. [102,103] In addition to cytotoxicity,B Pn anostructures are able to induce immune perturbationd epending on the surface conditions.…”

Section: Nanoscale Black Phosphorusmentioning

confidence: 99%

Inherent Chemotherapeutic Anti‐Cancer Effects of Low‐Dimensional Nanomaterials

Zhou

Chu

et al. 2019

Chemistry A European J

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Low-dimensional nanomaterials (LDNs) are receiving increasing attention in cancert herapy owing to their unique properties, especially the large surfacea rea-tovolume ratio. LDNs such as metallicn anoparticles (NPs), hydroxyapatite NPs, graphene derivatives, and black phosphorus (BP) nanosheets have been proposed for drug delivery, photothermal/photodynamic therapies, andm ultimodal theranostict reatments. The therapeutic effectiveness is mainly based on the physical characteristics of LDNs, but their inherent bioactivity has not been fully capitalized. In this Minireview,r ecent advances in the anti-cancer effects of varioust ypes of LDNs with inherentc hemotherapeutic bioactivity are described and the bioactivity mechanismsa re discussed on the cellular and molecular levels.B P, one of the newesta nd exciting members of the LDN family,i sh ighlighted owing to the excellent inherent bioactivity,s electivity,a nd biocompatibility in cancert herapy.L DNs and related derivatives possess inherentb ioactivity and selective chemotherapeutic effects suggesting large potentiala sn anostructured anti-cancer agentsinc ancer therapy.

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Different-sized black phosphorus nanosheets with good cytocompatibility and high photothermal performance

Abstract: As a new kind of two-dimensional (2D) material, black phosphorus (BP) has attracted explosive interest in biomedical applications.

Cited by 68 publications

References 50 publications

Black Phosphorus and its Biomedical Applications

Black Phosphorus and its Biomedical Applications

Recent Advances on Black Phosphorus for Biomedicine and Biosensing

Inherent Chemotherapeutic Anti‐Cancer Effects of Low‐Dimensional Nanomaterials

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