Different spectrophotometric methods for simultaneous determination of lesinurad and allopurinol in the new FDA approved pharmaceutical preparation; additional greenness evaluation

Simultaneous Estimation of Lesinurad and Allopurinol in the New FDA-Approved Products Using a Greener Normal-Phase HPTLC Method: Greenness Assessment Using the NEMI, Analytical Eco-Score, ChlorTox, and AGREE Methods

“…19−22 Furthermore, the AES scales for the area under the curve (AUC)-and artificial neural network (ANN)-based green spectrophotometric methods were reported as 78 and 75, respectively. 16 Overall, the AES scale for the present HPTLC method was superior to those of all reported methods. 16,19−22 The results of the ChlorTox scales for each greener solvent and the total ChlorTox scale for the current method are shown in Table 5.…”

“…According to reports, the AGREE scales for AUC-and ANN-based green spectrophotometry were 0.81 and 0.80, respectively, which were comparable to those of the HPTLC method used currently for the SME of LND and ALU. 16 Overall, the outcomes of all greenness methodologies showed that the existing procedure for the SME of LND and ALU in the FDAapproved fixed-dose combination tablet brands A and B had an excellent greener profile.…”

“…There have been numerous published analytical methods for the SME of LND and ALU in FDA-approved products. For the SME of LND and ALU in a standard drug and FDA-approved fixed-dose combination, conventional and greener spectrometry methods have been reported. For the SME of LND and ALU in an FDA-approved fixed-dose combination and human plasma, a spectrofluorimetry approach has also been reported .…”

A Review on Methods Developed for Estimation of Paracetamol in Combination with Other Drugs

“…Difference Spectrophotometry, Q-Absorbance Method [8] Allopurinol and Lesinurad Simultaneous Equation Method [9] Ambroxol, Salbutamol, and Theophylline Simultaneous Equation Method [10] Bromfenac and Ofloxacin Derivative Spectrophotometry [11] Esomeprazole and Naproxen Derivative Spectrophotometry [12] Fluorescein and Benoxinate Simultaneous Equation Method [13] Fluticasone and Formoterol Simultaneous Equation Method, Q-Absorbance Method [14] Furazolidone and Metronidazole Q-Absorbance Method [15] Hydrochlorothiazide and Carvedilol Q-Absorbance Method [16] Ledipasvir and Sofosbuvir Derivative Spectrophotometry [17] Levosulpiride and Rabeprazole sodium Derivative Spectrophotometry [18] Metformin HCl and Anagliptin Q-Absorbance Method [19] Nalidixic acid and Metronidazole Difference Spectrophotometry [20] Pamabrom, Mefenamic Acid, and Dicyclomine Hydrochloride Simultaneous Equation Method [21] Quinfamide and Mebendazole Q-Absorbance Method [22] Sofosbuvir and Velpatasvir Simultaneous Equation Method [23] Sumatriptan and Naproxen Simultaneous Equation Method [24] Telmisartan and Hydrochlorothiazide Q-Absorbance Method [25] Tinidazole and Norfloxacin Difference Spectrophotometry [26] Β-Carotene and Lycopene Simultaneous Equation Method [27] Paracetamol Paracetamol (PCM), widely known as Acetaminophen is an OTC medicine having analgesic and antipyretic properties used in mild to moderate pain and fever. It is chemically N-(4-hydroxyphenyl) acetamide (Figure 5).…”

Green fitted second derivative synchronous spectrofluorometric method for simultaneous determination of remdesivir and apixaban at Nano gram scale in the spiked human plasma

“…In particular, the determination of drugs down to the Nano- gram range represents a potential approach for determination of drugs in biological fluids [1] , [2] , [3] . In addition, analytical chemists have recently devoted themselves to making analytical methods more environmentally friendly and safer for humans by using solvents and chemicals with low environmental impact, low energy consumption, and lower waste generation [4] , [5] , [6] , [7] . Analytical methods based on fluorescence spectroscopy provide a more sensitive tool for determining compounds of interest that exhibit unique fluorescence features [8] , [9] , [10] .…”