Different Spectrophotometric Methods for the Determination of Cimetidine, Ranitidine Hydrochloride, and Famotidine

Kelani, Kahdiga M.; Aziz, Amer; Hegazy, Maha A.; Fattah, Laila Abdel

doi:10.1081/sl-120013890

Cited by 22 publications

(5 citation statements)

References 37 publications

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“…Two fast methods developed by Garcia et al [118] using batch and flow-injection procedures for CIM based on the formation of a green complex with Cu(II) in acetic/acetate medium, measured at 330 nm. Kelani et al [119] described three sensitive stability indicating spectrophotometric methods using sodium nitro prusside, 3-methyl-2-benzo-thiazolinone hydrazine, and cobalt(II), respectively.…”

Section: Spectrophotometric Methods Sensitive Spectrophotometric Metmentioning

confidence: 99%

An Overview of Analytical Determination of Diltiazem, Cimetidine, Ranitidine, and Famotidine by UV Spectrophotometry and HPLC Technique

Shafi

Siddiqui

Naseem

et al. 2013

Journal of Chemistry

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This review article recapitulates the analytical methods for the quantitative determinations of diltiazem and three H2receptor antagonists (cimetidine, ranitidine, and famotidine) by one of the spectroscopic technique (UV spectrophotometery) and separation technique such as high-performance liquid chromatography (HPLC). The clinical and pharmaceutical analysis of these drugs requires effective analytical procedures for quality control, pharmaceutical dosage formulations, and biological fluids. An extensive survey of the literature published in various analytical and pharmaceutical chemistry-related journals has been compiled in its review. A synopsis of reported spectrophotometric and high-performance liquid chromatographic methods for individual drug is integrated. This appraisal illustrates that majority of the HPLC methods reviewed are based on the quantitative analysis of drugs in biological fluids, and they are appropriate for therapeutic drug monitoring purpose.

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Section: Spectrophotometric Methods Sensitive Spectrophotometric Metmentioning

confidence: 99%

An Overview of Analytical Determination of Diltiazem, Cimetidine, Ranitidine, and Famotidine by UV Spectrophotometry and HPLC Technique

Shafi

Siddiqui

Naseem

et al. 2013

Journal of Chemistry

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“…En este sentido, debido al incremento del uso de este compuesto y la necesidad de efectuar controles de calidad, estudios farmacológicos y cinéticos, han traído como consecuencia el desarrollo de métodos analíticos que permitan la determinación de este fármaco en formulaciones farmacéuticas y fluidos biológicos empleando diversas técnicas de análisis instrumental, tales como la electroforesis capilar [3], la espectrofotometría [4] y la cromatografía liquida de altaresolución (HPLC) [5] que ha sido la más utilizada a pesar de no estar disponible para el control de calidad en muchos laboratorios. En consecuencia, la potenciometría directa con electrodos se ha convertido en una de las técnicas analíticas mas aplicadas hoy en día, ya que ofrece mayores ventajas al compararla con otros métodos analíticos, debido a que por su simplicidad en el diseño del dispositivo, adecuada selectividad y alta exactitud, al amplio intervalo de concentración de trabajo, a su fácil automatización y bajo costo puede ser aplicada a una gran variedad de muestras biológicas, clínicas y fármacos en los análisis de rutina de los laboratorios [6].…”

Section: Introductionunclassified

Construction of a selective electrode to cimetidine

Troconis

Palmar

Rolón³

et al. 2019

Rev. Téc. Ing. Univ. Zulia.

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“…For the determination of famotidine in pharmaceutical preparations as well as in biological fluids, several types of analytical methods have been reported in the specialty literature: colorimetric [14][15][16], potentiometric [17], voltammetric [18], capillary electrophoresis [19][20][21], spectrophotometric [22][23][24][25][26], thin layer chromatography [27][28][29] and HPLC [30][31][32][33][34][35][36]. HPLC methods allow simultaneous determination of famotidine with other pharmaceutical substances in multicomponent preparations and in biological media [34,36].…”

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confidence: 99%

HPLC-UV Method for Determination of Famotidine from Pharmaceutical Products

Nita¹,

Ţiţ²,

Copolovici³

et al. 2018

Rev. Chim.

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The aim of this study was to develop and validate a rapid, accurate, and exact method for the quantitative determination of famotidine in pharmaceutical products. The HPLC analyses were performed by using a mobile phase containing methanol:1% acetic acid solution=30:7 (v/v), at a flow rate of 0.4 mL/min.The total time of the method was 10 min, and the retention time of famotidine was 4.16 min. The detection was evaluated at l=267 nm. The method has been validated by using different validation parameters. The linear response of the detector for famotidine peak area was observed at concentrations ranging from 0.1 to 0.0001 mg mL-1 , resulting in a correlation coefficient of 0.99998. The values of the detection limit and of the quantification limit are 0.00048 mg mL-1 and 0.00148 mg mL-1, respectively. The method proposed allowed accurate (with a relative error of less than 2%) and precise (RSD values less than 2.0%) determination of famotidine content in pharmaceutical products and can be used for its rapid quantitative analysis.

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Different Spectrophotometric Methods for the Determination of Cimetidine, Ranitidine Hydrochloride, and Famotidine

Cited by 22 publications

References 37 publications

An Overview of Analytical Determination of Diltiazem, Cimetidine, Ranitidine, and Famotidine by UV Spectrophotometry and HPLC Technique

An Overview of Analytical Determination of Diltiazem, Cimetidine, Ranitidine, and Famotidine by UV Spectrophotometry and HPLC Technique

Construction of a selective electrode to cimetidine

HPLC-UV Method for Determination of Famotidine from Pharmaceutical Products

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