Different unfractionated heparin doses for preventing arterial thrombosis in children undergoing cardiac catheterization

Avila, Laura; Shah, Prakeshkumar S; Brandão, Leonardo R.

doi:10.1002/14651858.cd010196.pub2

Cited by 7 publications

(3 citation statements)

References 54 publications

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“…Some parents reported pain in legs in which the femoral vein was not accessed. Although arterial insufficiency from thrombosis secondary to catheterization may explain these findings, we did not find evidence that a history of catheterization of the femoral artery was associated with PTS [19]. Despite our difficulties with the instrument, it is important to note that the majority of children had mild PTS, which is consistent with previous studies [11,18].…”

Section: Discussionsupporting

confidence: 88%

Prevalence of post‐thrombotic syndrome after cardiac catheterization

Luceri

Tala

Weismann

et al. 2015

Pediatric Blood & Cancer

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BACKGROUND As the survival of children with cardiac disease increases, chronic complications of deep venous thrombosis from cardiac catheterization, particularly post-thrombotic syndrome, may be important to monitor for and treat, if needed. We aimed to determine the prevalence of this syndrome in children who underwent cardiac catheterization. PROCEDURE We conducted a cross-sectional study of children <18 years old at least 1 year from first catheterization through the femoral vein. We used the Manco-Johnson instrument, the only tool validated in children, to diagnose post-thrombotic syndrome. We defined the syndrome as a score ≥1. It was considered physically and functionally significant if the score was ≥1 in both physical and functional domains of the instrument. We also conducted ultrasonography to assess for thrombosis and valvular insufficiency. RESULTS We enrolled 62 children with a median age of 4 months during catheterization and a median of 5.4 years since catheterization. A total of 40 children had post-thrombotic syndrome (prevalence: 64.5%; 95% confidence interval: 51.3%–76.3%), the majority of which were mild. Presence of cyanotic congenital heart disease, total number of catheterizations, use of antithrombotic agents at any time after the first catheterization, age at first catheterization, or time since first catheterization was not associated with the syndrome. A total of 7 children (prevalence: 11.3%; 95% confidence interval: 3.2%–19.4%) had physically and functionally significant syndrome. None of the children had abnormalities on ultrasonography at the time of enrollment. CONCLUSIONS Post-thrombotic syndrome is a common complication after cardiac catheterization. Manifestations are usually mild and unlikely to require treatment.

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Section: Discussionsupporting

confidence: 88%

Prevalence of post‐thrombotic syndrome after cardiac catheterization

Luceri

Tala

Weismann

et al. 2015

Pediatric Blood & Cancer

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“…Fewer attempts at arterial puncture, use of a smaller sheath, maintaining a minimum procedure time, and ensuring that back bleed is present can prevent future occurrences of post-catheterization thrombosis ( 24 ). A review article published in 2014 still demonstrated uncertainty on the suitable dosage of heparin to prevent this major complication ( 25 ). Similarly, although patient case #2 underwent both TAE and PS, intraoperative blood transfusion was ultimately necessary.…”

Section: Discussionmentioning

confidence: 99%

A multi-step approach to the treatment of giant scalp congenital hemangiomas: a report of two cases

Nonnenmacher

Henkes

et al. 2023

Front. Surg.

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“…During cardiac catheterization, some centers routinely apply heparin infusion into the artery or the vein that received catheter with pediatric patients 7 . There is little research in literature studying the effects of giving prophylactic systemic heparin during cardiac catheterization on the frequency of thrombosis in newborns 8 .…”

Section: Introductionmentioning

confidence: 99%

Arterial Thrombosis Secondary to Cardiac Catheterization in Neonates

Erol¹,

Aydın²,

Çınar³

et al. 2019

Dicle Tıp Dergisi

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Methods: Twenty newborns that received femoral artery catheterization within 6-month period were enrolled in this study. Blood samples were taken for complete blood count, prothrombin, activated partial thromboplastin time, INR ratio and mutations of factorV Leiden, prothrombin 20210A, methylenetetrahydrofolate reductase C667T and A1298 before the procedure. 100 U/kg bolus of heparin was infused during catheterization. 28 U/kg/hour infusion of heparin was given to the patients with clinically suspected thrombosis during first few hours after catheterization. Doppler ultrasonography was performed in all patients within 6 hours after catheterization. Results: The gestational age of patients ranged from 31 to 40 weeks (median 39). Mean birth weight was 2996 ± 589 (1880-4000 gr). Arterial thrombosis was detected in 10 patients by Doppler USG. On development of arterial thrombosis, patient age, gender, diagnosis, treatments, platelet count, hemoglobin, prothrombin and activated partial thromboplastin time values, FactorV Leiden, prothrombin 20210A, methylenetetrahydrofolate reductase C667T and A1298 mutations were found as not impacting (p>0.05). Those who were found to have thrombosis in Doppler ultrasonography had lower INR levels compared to others (p= 0.023).

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Different unfractionated heparin doses for preventing arterial thrombosis in children undergoing cardiac catheterization

Cited by 7 publications

References 54 publications

Prevalence of post‐thrombotic syndrome after cardiac catheterization

Prevalence of post‐thrombotic syndrome after cardiac catheterization

A multi-step approach to the treatment of giant scalp congenital hemangiomas: a report of two cases

Arterial Thrombosis Secondary to Cardiac Catheterization in Neonates

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