Differential abnormalities in plasma 5-HIAA and platelet serotonin concentrations in violent suicide attempters Relationships with impulsivity and depression

Seasonality and Climatic Associations with Violent and Nonviolent Suicide: A Population-Based Study

“…These include seasonal variations in physiological conditions including: plasma levels of serotonin, 5-hydroxyindoleacetic acid, cerebrospinal fluid 3-methoxy-4-hydroxyphenylglycol concentrations, plasma melatonin concentration and serum cholesterol level, as well as seasonal variations in metabolic and immune disorders [24][25][26] . However, temporal studies of circannual variations by season of the above factors and of violent suicides are still very scarce.…”

A neurochemical yin and yang: does serotonin activate and norepinephrine deactivate the prefrontal cortex?

“…A lower cerebrospinal fluid (CSF) concentration of the 5-HT metabolite, 5-HIAA, has been associated with a greater degree of impulsivity (and suicidality) (Roggenbach et al 2002). In a group of drug-free suicide attempters and control subjects, impulsive suicide attempters had lower plasma 5-HIAA than non-impulsive attempters or control subjects (Spreux-Varoquaux et al 2001). There is evidence that impulsive violent offenders who tend to behave aggressively while intoxicated on alcohol have low brain 5-HT turnover (Virkkunen et al 1995).…”

Effect of glucose on tobacco craving. Is it mediated by tryptophan and serotonin?

“…All results of blood serotonin were adjusted for 10 9 platelets. In the absence of a serotonin uptake inhibitor or a monoamine oxidase B inhibitor, blood serotonin concentration is a good indicator of serotonin balance (Spreux-Varoquaux et al 2001;Gobbi et al 2003).…”