1992
DOI: 10.1152/ajpgi.1992.263.1.g38
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Differential alterations in microvascular perfusion in various organs during early and late sepsis

Abstract: Although cellular dysfunction occurs very early in sepsis, it remains controversial whether this is solely due to a decrease in tissue perfusion. Recent studies have indicated that while active hepatocellular function was depressed, hepatic surface microvascular blood flow (MBF) increased in early sepsis but decreased in late sepsis as produced by cecal ligation and puncture (CLP). However, it is not known whether microvascular hyperperfusion in early sepsis and microvascular hypoperfusion in late sepsis are c… Show more

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Cited by 45 publications
(37 citation statements)
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“…In both groups, venular dilation was observed, though that of the 2 ϫ 10 7 -group was far more pronounced. These observations, again the most likely explanation being the difference in amount of pathologic agent released, are conform to observations made for endotoxemia [31].…”
Section: Microhemodynamicssupporting
confidence: 90%
See 1 more Smart Citation
“…In both groups, venular dilation was observed, though that of the 2 ϫ 10 7 -group was far more pronounced. These observations, again the most likely explanation being the difference in amount of pathologic agent released, are conform to observations made for endotoxemia [31].…”
Section: Microhemodynamicssupporting
confidence: 90%
“…We could observe two opposing reactions depending on the degree of bacterial contamination. Controversy remains as to whether initial arterial reaction is one of vasoconstriction or rather vasodilation [31,32]. In line with Zweifach et al [33], a dose-dependent increase (2 ϫ 10 5 -group) and decrease (2 ϫ 10 7 -group) in vascular reactivity to catecholamines, culminating in a complete absence of reactivity, must be postulated.…”
Section: Microhemodynamicsmentioning
confidence: 94%
“…Cardiovascular dysfunction, specifically a reduction in cardiac contractility, is often observed in severe sepsis (33). LVDP and the maximal rate of ventricular pressure development (+dP/dt max ) were significantly decreased by 83.1% and 81.2%, respectively, compared with sham rats.…”
Section: Combined Human Ghrelin and Gh Improves Cardiovascular Functimentioning
confidence: 97%
“…[1][2][3][4] The pathophysiological responses to sepsis usually include an initial hyperdynamic phase (early sepsis) followed by a hypodynamic phase (late sepsis). [5][6][7] The intestinal tract plays an important physiologic and metabolic role during the catabolic state. Glutamine is the principal fuel used by the gut 8,9 and may be an essential component for the maintenance of gut structure and function.…”
Section: Introductionmentioning
confidence: 99%