Differential behavioral and neuroendocrine effects of repeated nicotine in adolescent and adult rats

Cruz, Fábio C.; DeLucia, Roberto; Planeta, Cleópatra da Silva

doi:10.1016/j.pbb.2004.12.007

Cited by 52 publications

(42 citation statements)

References 57 publications

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“…Differences in stress responses may differentially affect the pattern of nicotine SA in adolescents compared to adults. Cruz et al (2005) reported that adult rats developed tolerance to nicotine-induced corticosterone release, whereas adolescents did not. Therefore, it is conceivable that the persistence of nicotine-induced corticosterone release may have enhanced the motivation (Marinelli et al, 1996) to self-administer nicotine in adolescent rats.…”

Section: Adolescent Nicotine Self-administration H Chen Et Almentioning

confidence: 99%

“…Adolescents are more sensitive to locomotor enhancement by acute and chronic nicotine (Faraday et al, 2001(Faraday et al, , 2003, and are less sensitive to locomotor suppression (Vastola et al, 2002). However, adolescents display less robust nicotine-induced locomotor sensitization Cruz et al, 2005) and cue conditioning compared to adult rats. Conflicting results have been reported for conditioned place preference.…”

Section: Introductionmentioning

confidence: 99%

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Acquisition of Nicotine Self-Administration in Adolescent Rats Given Prolonged Access to the Drug

Chen

Matta

Sharp

2006

Neuropsychopharmacol

105

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As most human tobacco use begins during adolescence and ongoing development of the adolescent central nervous system could affect acquisition of nicotine self-administration (SA), our established rat SA procedure was modified to study adolescent acquisition of SA with prolonged access to nicotine (23 h/day). Postnatal age 43-45 female Lewis rats, without prior shaping, conditioning, or food deprivation, were housed in operant chambers equipped with two levers; pressing the active lever triggered an i.v. injection of nicotine. By the 10th day of SA, rats receiving 7.5, 15, 30, or 60 mg/kg/injection nicotine (free base) obtained 23716, 5078, 6578, or 4875 injections (mean7SE), respectively. In the 30 mg/kg/injection group, active : inactive ratio was greater than 2 after SA day 4; 92% of injections occurred during the 12-h active (dark) phase of the light cycle. Main effects (analysis of variance) were shown for day and lever (ie active vs inactive) (po0.001). Adolescent males showed similar dose-dependent nicotine SA. With the increasing workload imposed by raising the fixed ratio (FR), less nicotine was self-administered at FR 5 and 7 compared to FR 1 and 3. In comparison to adult females selfadministering 30 mg/kg/injection of nicotine at FR 1, adolescents acquired nicotine SA at an accelerated rate (po0.05) and received a greater number of injections (po0.05) by day 10. In conclusion, when given prolonged access to the drug, both female and male adolescent Lewis rats rapidly acquire nicotine SA within the dosage range and FR constraints previously observed in adult Lewis rats. However, adolescent females acquired the behavior more rapidly and attained higher levels of stable nicotine SA than adults.

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Section: Adolescent Nicotine Self-administration H Chen Et Almentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Acquisition of Nicotine Self-Administration in Adolescent Rats Given Prolonged Access to the Drug

Chen

Matta

Sharp

2006

Neuropsychopharmacol

105

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“…Adolescents are more sensitive to the stimulant actions of NIC on locomotor activity [Adriani et al, 2002;Collins and Izenwasser, 2004;Cruz et al, 2005;Schochet et al, 2004], and it has recently been reported that rats pretreated with NIC during adolescence display higher novelty-induced hyperactivity than controls . In contrast, adolescent rats do not exhibit signs of NIC cue conditioning and display less sensitization to its locomotor effects [Cruz et al, 2005;Schochet et al, 2004] than adult animals. Differences in the reinforcing effects of NIC have also been reported and suggest that the drug is more rewarding during early adolescence than at later ages [Belluzzi et al, 2004;Brielmaier et al, 2006;Kota et al, 2007;Shram et al, 2006].…”

Section: Introductionmentioning

confidence: 99%

Differential sensitivity to the effects of nicotine and bupropion in adolescent and adult male OF1 mice during social interaction tests

Gómez

Carrasco

Redolat

2008

Aggressive Behavior

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Few studies have compared the action of both nicotine (NIC) and bupropion (BUP), an antidepressant used to treat NIC dependence, on social and aggressive behavior at different ages. This study aims to determine whether these drugs produce differential effects in adolescent (postnatal day: 36-37) and adult (postnatal day: 65-66) mice that have been housed individually for 2 weeks in order to induce aggressive behavior. Mice received BUP (40, 20, or 10 mg/kg), NIC (1, 0.5, and 0.25 mg/kg as base), or vehicle earlier to a social interaction test. BUP (40 mg/kg) decreased social investigation and increased nonsocial exploration in both adolescent and adult mice. The same effects were also observed in adult mice administered with a lower dose of the same drug (20 mg/kg). In adolescents, NIC (1 mg/kg) decreased social investigation, but this effect did not reach statistical significance in adults. In conclusion, a differential sensitivity to the effects of NIC or BUP emerged in some of the behavioral categories when the two age groups were compared.

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“…Contudo, após a administração prolongada observa-se aumento progressivo desse comportamento, caracterizando assim o desenvolvimento da sensibilização comportamental (Domino, 2001;Shim et al, 2001;Cruz et al, 2005).…”

Section: Sensibilização Comportamental E Dependência à Nicotinaunclassified

Bases neurofisiológicas da dependência do tabaco

Planeta¹,

Cruz²

2005

Rev. psiquiatr. clín.

Self Cite

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ResumoA maioria dos estudos pré-clínicos e clínicos aponta a nicotina como o principal agente responsável pelo desenvolvimento da dependência ao tabaco. Muitos trabalhos têm demonstrado que as bases neurais da dependência à nicotina são semelhantes àquelas das outras drogas de abuso. A nicotina induz preferência condicionada por lugar e auto-administração e, portanto, atua como reforçador positivo, esse efeito parece ser mediado pelo sistema dopaminérgico mesolímbico. A nicotina também induz à sensibilização comportamental que é provavelmente resultante de alterações da expressão gênica do núcleo acumbens induzidas pela exposição prolongada a essa substância. A suspensão do uso de nicotina resulta em síndrome de abstinência. As evidências indicam que esses sinais e sintomas sejam mediados por receptores colinérgicos nicotínicos centrais e periféricos. Outros neurotransmissores, como por exemplo a serotonina e os peptídeos opióides, também podem estar envolvidos na mediação da dependência e síndrome de abstinência à nicotina. A revisão da literatura mostra a complexidade dos efeitos da nicotina no organismo. A integração entre as abordagens comportamental, neuroquímica e molecular possibilitará a compreensão dos mecanismos neurais da dependência ao tabaco e fornecerá as bases para o desenvolvimento racional de agentes terapêuticos que possam ser utilizados para o tratamento da dependência e síndrome de abstinência ao tabaco.Palavras-chave: Nicotina, tabaco, dependência, síndrome de abstinência. AbstractIt is generally accepted that nicotine is the major component in tobacco smoke responsible for addiction. Several studies have demonstrated that the neural mechanisms underlying nicotine addiction have much in common with those underlying the mechanisms of addiction to other drugs. Thus, it has been shown that nicotine induces conditioning place preference and self-administration across many species. Repeated treatment with nicotine also induces behavioral sensitization in rodents. These behavioral effects of nicotine seem to mediate through the meso limbic dopamine system. Smoke cessation results in an abstinence syndrome that seems to be mediated by both peripheral and central nicotinic acetylcholine receptors. In addition, other neurotransmitters systems are involved in the mediation of

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Differential behavioral and neuroendocrine effects of repeated nicotine in adolescent and adult rats

Cited by 52 publications

References 57 publications

Acquisition of Nicotine Self-Administration in Adolescent Rats Given Prolonged Access to the Drug

Acquisition of Nicotine Self-Administration in Adolescent Rats Given Prolonged Access to the Drug

Differential sensitivity to the effects of nicotine and bupropion in adolescent and adult male OF1 mice during social interaction tests

Bases neurofisiológicas da dependência do tabaco

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