Differential brain activation during facial emotion discrimination in first-episode schizophrenia

Reske, Martina; Habel, Ute; Kellermann, Thilo; Backes, Volker; Shah, N. Jon; Wilmsdorff, Martina von; Gäebel, Wolfgang; Zilles, Karl; Schneider, Frank

doi:10.1016/j.jpsychires.2008.10.012

Cited by 70 publications

(48 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Of the 12 studies included in Barkl et al [30] , only three examined sex differences in FEP. None of the three studies found sex differences in FEP on identification tasks in recent-onset samples [73][74][75] . Of the 81 non-overlapping studies that examined sex differences in FEP in schizophrenia included in Kohler et al [7] , Chan et al [5] , and Savla et al [9] , four studies examined sex differences in FEP in samples of either recent-onset schizophrenia or children and adolescents diagnosed with schizophrenia-spectrum disorders (these studies were not included in Barkl et al [30] ).…”

Section: Early and Recent-onset Schizophreniamentioning

confidence: 83%

“…We found one study that examined FEP in an early onset group in our PubMed search, but the authors did not report sex differences [78] . In summary, out of seven studies of FEP in early or recent-onset schizophrenia that examined sex differences, five did not find sex differences [41,[73][74][75][76] . One study found that boys outperformed girls [77] and one study found that recently diagnosed women outperformed men [35] .…”

Section: Early and Recent-onset Schizophreniamentioning

confidence: 84%

See 1 more Smart Citation

Facial emotion perception in schizophrenia: Does sex matter?

Mote

Kring

2016

WJP

View full text Add to dashboard Cite

AIM:To review the literature on sex differences in facial emotion perception (FEP) across the schizophrenia spectrum. METHODS:We conducted a systematic review of empirical articles that were included in five separate meta-analyses of FEP across the schizophrenia spectrum, including meta-analyses that predominantly examined adults with chronic schizophrenia, people with early (onset prior to age 18) or recent-onset (experiencing their first or second psychotic episode or illness duration less than 2 years) schizophrenia, and unaffected first-degree relatives of people with schizophrenia. We also examined articles written in English (from November 2011 through June 2015) that were not included in the aforementioned metaanalyses through a literature search in the PubMed database. All relevant articles were accessed in full text. We examined all studies to determine the sample sizes, diagnostic characteristics, demographic information, methodologies, results, and whether each individual study reported on sex differences. The results from the meta-analyses themselves as well as the individual studies are reported in tables and text. RESULTS:We retrieved 134 articles included in five separate meta-analyses and the PubMed database that examined FEP across the schizophrenia spectrum. Of these articles, 38 examined sex differences in FEP. Thirty of these studies did not find sex differences in FEP in either chronically ill adults with schizophrenia, early-onset or recently diagnosed people with schizophrenia, or first-degree relatives of people with schizophrenia. Of the eight studies that found sex differences in FEP, three found that chronically ill women outperformed men, one study found that girls with early-onset schizophrenia outperformed boys, and two studies found that women (including first-degree relatives, adults with schizophrenia, and the healthy control group) outperformed men on FEP tasks. In total, six of the eight studies that examined sex differences in FEP found that women outperformed men across the SYSTEMATIC REVIEWS Core tip: People with schizophrenia exhibit deficits in facial emotion perception (FEP) compared to healthy controls. These deficits are associated with poorer functioning and more severe symptoms. Although the literature to date suggests that there are few sex differences in FEP in schizophrenia, continued assessment of sex differences in FEP can help researchers and clinicians better understand other sex differences in the disorder and assist in treatment development aimed at improving functioning in people with schizophrenia. This review summarizes and critically evaluates the literature on FEP across the schizophrenia spectrum, focusing on the evidence related to sex differences in FEP.Mote J, Kring AM. Facial emotion perception in schizophrenia: Does sex matter? World J Psychiatr 2016; 6(2): 257-268

show abstract

Section: Early and Recent-onset Schizophreniamentioning

confidence: 83%

Section: Early and Recent-onset Schizophreniamentioning

confidence: 84%

Facial emotion perception in schizophrenia: Does sex matter?

Mote

Kring

2016

WJP

View full text Add to dashboard Cite

show abstract

“…These impairments have been documented in at-risk popula-tions, early stages of disease and in patients' unaffected relatives [76][77][78][79][80][81] . EP and ToM impairments are correlated with worse functional outcome [82][83][84][85][86][87][88][89][90] .…”

Section: Cognitivismmentioning

confidence: 99%

What Is It like to Be a Person with Schizophrenia in the Social World? A First-Person Perspective Study on Schizophrenic Dissociality – Part 1: State of the Art

Stanghellini

Ballerini

2011

Psychopathology

View full text Add to dashboard Cite

This is a critical review of research on the subjective experience of social dysfunction in persons with schizophrenia. Studies from the phenomenological and cognitive paradigms are examined, and significant outcomes and shortcomings are pointed out. Clinical phenomenologists have mainly interpreted schizophrenic dissociality as an anomaly of prereflexive attunement. The main shortcoming of phenomenological research is that it lacks adequate methodology to collect reliable data since most studies are based on the analysis of a few typical cases. Cognitivism has reliably documented disorders of social functioning in large-scale experimental studies. The main shortcoming of most cognitive paradigms is that they do not properly investigate the personal level of experience in real-world functioning. We conclude that there is a need to reliably collect data through quantitative as well as qualitative methodology as established and accepted by the scientific community in the area of schizophrenic dissociality, reflecting the subjective experiences of people with schizophrenia in the real world.

show abstract

“…Instead, patients showed reduced activity in the bilateral angular gyri and right fusiform gyrus while performing the emotional Simon task. Reduced angular gyrus activity in schizophrenia has been observed during facial emotion discrimination (Reske et al., 2009; Streit et al., 2001) or social cognition (Thakkar, Peterman, & Park, 2014). Patients with schizophrenia have also shown neural deficits in the fusiform gyrus during emotional face processing (Gur et al., 2002; Li, Chan, McAlonan, & Gong, 2010; Wolf et al., 2015).…”

Section: Discussionmentioning

confidence: 99%

Involvement of amygdala–prefrontal dysfunction in the influence of negative emotion on the resolution of cognitive conflict in patients with schizophrenia

et al. 2018

View full text Add to dashboard Cite

IntroductionPatients with schizophrenia often have impaired cognition and abnormal conflict control. Conflict control is influenced by the emotional values of stimuli. This study investigated the neural basis of negative emotion interference with conflict control in schizophrenia.MethodsSeventeen patients with schizophrenia and 20 healthy controls underwent functional magnetic resonance imaging while performing the emotional Simon task, in which positive or negative emotional pictures were located in congruent or incongruent positions. Analysis was focused on identifying brain regions with the significant interaction among group, emotion, and conflict in whole brain voxel‐wise analysis, and abnormality in their functional connectivity in the patient group.ResultsThe regions showing the targeted interaction was the right amygdala, which exhibited significantly reduced activity in the negative congruent (t = −2.168, p = 0.036) and negative incongruent (t = −3.273, p = 0.002) conditions in patients versus controls. The right amygdala also showed significantly lower connectivity with the right dorsolateral prefrontal cortex in the cognitive and emotional loading contrast (negative incongruent—positive congruent) in patients versus controls (t = −5.154, p < 0.01), but not in the cognitive‐only or emotional‐only loading contrast.ConclusionsThese results suggest that negative emotion interferes with cognitive conflict resolution in patients with schizophrenia due to amygdala–dorsolateral prefrontal cortex disconnection. Based on these findings, interventions targeting conflict control under negative emotional influence may promote cognitive rehabilitation in patients with schizophrenia.

show abstract

Differential brain activation during facial emotion discrimination in first-episode schizophrenia

Cited by 70 publications

References 44 publications

Facial emotion perception in schizophrenia: Does sex matter?

Facial emotion perception in schizophrenia: Does sex matter?

What Is It like to Be a Person with Schizophrenia in the Social World? A First-Person Perspective Study on Schizophrenic Dissociality – Part 1: State of the Art

Involvement of amygdala–prefrontal dysfunction in the influence of negative emotion on the resolution of cognitive conflict in patients with schizophrenia

Contact Info

Product

Resources

About