Differential Brain Metabolic Predictors of Response to Paroxetine in Obsessive-Compulsive Disorder Versus Major Depression

Saxena, Sanjaya; Brody, Arthur L.; Ho, Matthew L.; Zohrabi, Narineh; Maidment, Karron M.; Baxter, Lewis R.

doi:10.1176/appi.ajp.160.3.522

Cited by 194 publications

(165 citation statements)

References 82 publications

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“…29 The brain region with the greatest prospect of pretreatment prediction is the rostral ACC. 6–8 Metabolic and electrophysiological activity changes in depression are linked in this particular part of the brain. 10 Although the rostral ACC is anatomically connected to the subgenual ACC, these regions are cytoarchitecturally distinct.…”

Section: Discussionmentioning

confidence: 99%

“…Higher than normal activity in the rostral anterior cingulate cortex (ACC) has been shown to predict response to antidepressant medication in patients with major depression. 6–9 High theta power in the rostral ACC has also been found to predict response in a similar population. 10 This same group found that metabolism and theta activity are linked in this region.…”

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confidence: 94%

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Subgenual Cingulate Theta Activity Predicts Treatment Response of Repetitive Transcranial Magnetic Stimulation in Participants With Vascular Depression

Narushima

McCormick²,

Yamada³

et al. 2010

Journal of Neuropsychiatry

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Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for depression. Increased metabolism in the anterior cingulate cortex (ACC) is a known predictor for antidepressant response. The authors assessed whether increased theta power within the ACC predicts rTMS response in participants with vascular depression. Sixty-five participants were randomized to active or sham rTMS. Outcome was assessed using the Hamilton Depression Rating Scale. Electroencephalography was obtained, and comparisons were made among each group with a normative database using low-resolution electromagnetic tomography. Results suggest that vascular depression participants respond well to rTMS and that increased low-theta power in the subgenual ACC predicts response to rTMS.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 94%

Subgenual Cingulate Theta Activity Predicts Treatment Response of Repetitive Transcranial Magnetic Stimulation in Participants With Vascular Depression

Narushima

McCormick²,

Yamada³

et al. 2010

Journal of Neuropsychiatry

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“…Although it has been suggested that the serotonin neurotransmitter system is asymmetrically distributed in the brain (Mandell and Knapp, 1979;Tucker and Williamson, 1984), the findings of postmortem studies have been inconsistent (Arato et al, 1991a;Arora and Meltzer, 1991). Neuroimaging studies have provided evidence that individual differences among depressed patients in regional brain activity are related to subsequent response to an SSRI or other antidepressants (Buchsbaum et al, 1997;Mayberg et al, 1997;Brody et al, 1999;Hoehn-Saric et al, 2001;Saxena et al, 2003;Davidson et al, 2003). Relatively greater activity of the left rectal gyrus (Buchsbaum et al, 1997), anterior cingulate (Davidson et al, 2003), or prefrontal regions (Hoehn-Saric et al, 2001) was reported to be predictive of favorable response to antidepressants.…”

Section: Discussionmentioning

confidence: 99%

“…There is, however, growing evidence that individual differences among depressed patients on genetic (Zanardi et al, 2001), biochemical (Figueras et al, 1999), neuroimaging (Buchsbaum et al, 1997;Mayberg et al, 1997;Brody et al, 1999;Saxena et al, 2003;Davidson et al, 2003), electrophysiologic (Bruder et al, 2001;Cook and Leuchter, 2001;Pizzagalli et al 2001;Kalayam and Alexopoulos, 2003;Mulert et al, 2002), and neurocognitive (Dunkin et al, 2000) measures are associated with therapeutic response to an SSRI or other antidepressants.…”

Section: Introductionmentioning

confidence: 99%

Dichotic Listening Tests of Functional Brain Asymmetry Predict Response to Fluoxetine in Depressed Women and Men

Bruder

Stewart

McGrath

et al. 2004

Neuropsychopharmacol

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Patients having a depressive disorder vary widely in their therapeutic responsiveness to a selective serotonin reuptake inhibitor (SSRI), but there are no clinical predictors of treatment outcome. Studies using dichotic listening, electrophysiologic and neuroimaging measures suggest that pretreatment differences among depressed patients in functional brain asymmetry are related to responsiveness to antidepressants. Two new studies replicate differences in dichotic listening asymmetry between fluoxetine responders and nonresponders, and demonstrate the importance of gender in this context. Right-handed outpatients who met DSM-IV criteria for major depression, dysthymia, or depression not otherwise specified were tested on dichotic fused-words and complex tones tests before completing 12 weeks of fluoxetine treatment. Perceptual asymmetry (PA) scores were compared for 75 patients (38 women) who responded to treatment and 39 patients (14 women) who were nonresponders. Normative data were also obtained for 101 healthy adults (61 women). Patients who responded to fluoxetine differed from nonresponders and healthy adults in favoring left-over righthemisphere processing of dichotic stimuli, and this difference was dependent on gender and test. Heightened left-hemisphere advantage for dichotic words in responders was present among women but not men, whereas reduced right-hemisphere advantage for dichotic tones in responders was present among men but not women. Pretreatment PA was also predictive of change in depression severity following treatment. Responder vs nonresponder differences for verbal dichotic listening in women and nonverbal dichotic listening in men are discussed in terms of differences in cognitive function, hemispheric organization, and neurotransmitter function.

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“…84,85 The altered metabolic state in the brain regions examined during depression and antidepressant treatments has been demonstrated by 18-fluorodeoxyglucose PET studies. 86,87 GPD3 was found to be transcriptionally regulated in relation to changes in neuronal activity and antidepressant drug treatment. 88 Enhanced expression of GPD3 might reflect increased metabolic requirements and contribute to a higher Na/K ATPase activity that can accelerate the rate of neuronal repolarization.…”

Section: Number Of Transcripts Affected By Single and Multiple Treatmmentioning

confidence: 99%

Region-specific transcriptional changes following the three antidepressant treatments electro convulsive therapy, sleep deprivation and fluoxetine

et al. 2006

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The significant proportion of depressed patients that are resistant to monoaminergic drug therapy and the slow onset of therapeutic effects of the selective serotonin reuptake inhibitors (SSRIs)/serotonin/noradrenaline reuptake inhibitors (SNRIs) are two major reasons for the sustained search for new antidepressants. In an attempt to identify common underlying mechanisms for fast-and slow-acting antidepressant modalities, we have examined the transcriptional changes in seven different brain regions of the rat brain induced by three clinically effective antidepressant treatments: electro convulsive therapy (ECT), sleep deprivation (SD), and fluoxetine (FLX), the most commonly used slow-onset antidepressant. Each of these antidepressant treatments was applied with the same regimen known to have clinical efficacy: 2 days of ECT (four sessions per day), 24 h of SD, and 14 days of daily treatment of FLX, respectively. Transcriptional changes were evaluated on RNA extracted from seven different brain regions using the Affymetrix rat genome microarray 230 2.0. The gene chip data were validated using in situ hybridization or autoradiography for selected genes. The major findings of the study are:1. The transcriptional changes induced by SD, ECT and SSRI display a regionally specific distribution distinct to each treatment. 2. The fast-onset, short-lived antidepressant treatments ECT and SD evoked transcriptional changes primarily in the catecholaminergic system, whereas the slow-onset antidepressant FLX treatment evoked transcriptional changes in the serotonergic system. 3. ECT and SD affect in a similar manner the same brain regions, primarily the locus coeruleus, whereas the effects of FLX were primarily in the dorsal raphe and hypothalamus, suggesting that both different regions and pathways account for fast onset but short lasting effects as compared to slow-onset but long-lasting effects. However, the similarity between effects of ECT and SD is somewhat confounded by the fact that the two treatments appear to regulate a number of transcripts in an opposite manner. 4. Multiple transcripts (e.g. brain-derived neurotrophic factor (BDNF), serum/glucocorticoidregulated kinase (Sgk1)), whose level was reported to be affected by antidepressants or behavioral manipulations, were also found to be regulated by the treatments used in the present study. Several novel findings of transcriptional regulation upon one, two or all three treatments were made, for the latter we highlight homer, erg2, HSP27, the proto oncogene ret, sulfotransferase family 1A (Sult1a1), glycerol 3-phosphate dehydrogenase (GPD3), the orphan receptor G protein-coupled receptor 88 (GPR88) and a large number of expressed sequence tags (ESTs). 5. Transcripts encoding proteins involved in synaptic plasticity in the hippocampus were strongly affected by ECT and SD, but not by FLX.The novel transcripts, concomitantly regulated by several antidepressant treatments, may represent novel targets for fast onset, long-duration antidepressants.

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Differential Brain Metabolic Predictors of Response to Paroxetine in Obsessive-Compulsive Disorder Versus Major Depression

Cited by 194 publications

References 82 publications

Subgenual Cingulate Theta Activity Predicts Treatment Response of Repetitive Transcranial Magnetic Stimulation in Participants With Vascular Depression

Subgenual Cingulate Theta Activity Predicts Treatment Response of Repetitive Transcranial Magnetic Stimulation in Participants With Vascular Depression

Dichotic Listening Tests of Functional Brain Asymmetry Predict Response to Fluoxetine in Depressed Women and Men

Region-specific transcriptional changes following the three antidepressant treatments electro convulsive therapy, sleep deprivation and fluoxetine

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