Differential Cellular and Molecular Markers in Idiopathic Pulmonary Fibrosis.

Desai, B. L.; Mattson, Jeanine D.; Paintal, Harman S.; Nathan, Manjari; Beaumont, Maribel; Malinao, Maria-Christina; Shen, Fran; Li, Y; Basham, Beth; Canfield, James; Malefyt, René de Waal; McClanahan, Terri; Fick, Robert B.; Krishna, Ganesh

doi:10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a3488

B60. Pulmonary Fibrosis: The Fibroblast 2009

DOI: 10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a3488

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Differential Cellular and Molecular Markers in Idiopathic Pulmonary Fibrosis.

B. L. Desai¹,

Jeanine D. Mattson²,

Harman S. Paintal³

et al.

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2011

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“…Data reported by us in IPF subjects support and extend to humans the observations in the murine system. 1 75 Former 74 22 78 2 72 Former 41 17 65 3 81 Never 45 50 60 4 67 Never 52 70 75 5 73 Former 84 85 73 6 78 Never 60 50 68 7 68 Never 36 37 66 8 61 Never 36 18 54 9 73 Current 85 29 99 10 69 Never 53 50 69.5 ) * IPF diagnosis was made according to American Thoracic Society/European Respiratory Society consensus classification (16). * * All IPF subjects were male.…”

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Differential expression of monocyte/macrophage- selective markers in human idiopathic pulmonary fibrosis

Desai¹,

Mattson²,

Paintal

et al. 2011

Experimental Lung Research

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Idiopathic interstitial pneumonias are a group of idiopathic interstitial lung diseases of which idiopathic pulmonary fibrosis (IPF) is the lesion of usual interstitial pneumonia. Although the pathogenic mechanisms remain incompletely understood, disease-specific changes in blood, a readily accessible biospecimen, have not been fully characterized. To identify biomarkers from blood and sera, the immune status of IPF patients and control subjects without structural lung disease was quantified by measuring cell surface markers, mRNA levels, and serum proteins. Statistically significant differences in cellular and molecular markers were observed between the 2 groups. The cytokine receptor IL-17RB was significantly higher in CD14+ peripheral blood mononuclear cells (PBMCs) from IPF patients, whereas expression of the chemokine receptor CXCR4 was lower. Gene expression analyses identified 18 differentially expressed genes out of 195 selected. Of these, EMR1, CCR3, UPAR, FCGR2A, OPN, CEACAM3, CD16a, CD18, CD11b, LTF, and LCN2 were up-regulated, whereas IL-17RB, IL-10, PDGFA, CD301/Clec10a, CD25/IL-2RA, IL-23p19, and IL-15 were down-regulated in IPF. Differentially regulated genes were in the functional areas of inflammation and cell signaling. Serum levels of UPAR and OPN were higher in IPF. These observations reveal significant differences in cell and molecular markers involved in monocyte/macrophage activation and migration, and suggest a role for IL-17RB in IPF.

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confidence: 99%

Differential expression of monocyte/macrophage- selective markers in human idiopathic pulmonary fibrosis

Desai¹,

Mattson²,

Paintal

et al. 2011

Experimental Lung Research

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Differential Cellular and Molecular Markers in Idiopathic Pulmonary Fibrosis.

Cited by 1 publication

References 0 publications

Differential expression of monocyte/macrophage- selective markers in human idiopathic pulmonary fibrosis

Differential expression of monocyte/macrophage- selective markers in human idiopathic pulmonary fibrosis

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