Differential Changes in Gut Microbiota After Gastric Bypass and Sleeve Gastrectomy Bariatric Surgery Vary According to Diabetes Remission

Murphy, Rinki; Tsai, Peter; Jüllig, Mia; Liu, Amy; Plank, Lindsay D.; Booth, Michael

doi:10.1007/s11695-016-2399-2

Cited by 246 publications

(258 citation statements)

References 35 publications

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“…Murine model experiments indicate that the microbiome plays a critical role in weight gain following transient loss of obesity 218 . In accordance with this observation, recent human translational research showed consistent increase in the Roseburia genus in patients with successful resolution of diabetes following both RYGB and SG surgery 219 . Such microbiome changes associated with fecal metabolite alterations, may be relevant for modulating epigenetic mechanisms.…”

Section: Introductionsupporting

confidence: 79%

“…Vertical sleeve gastrectomy results in the resection of about 80% of the greater curvature portion of the stomach and causes a restriction of food intake, acceleration of gastric emptying and alteration of gut hormones affecting satiety and appetite. VSG was noted to produce only modest microbial changes compared to RYGB 219 but did lead an increase in the Bacteroidetes/Firmicutes ratio and a decrease in Eubacterium rectale, Ruminococcus obeum, Lachnospiraceae bacterium and F. prausnitzii (in those with impaired glucose tolerance only) 227 . VSG also led to an increase in malabsorption due to loss of energy-rich fatty acids in the stool, impaired bile acid circulation 227 and resulted in greater capacity for metabolism of amino acids 219 .…”

Section: Introductionmentioning

confidence: 99%

“…VSG was noted to produce only modest microbial changes compared to RYGB 219 but did lead an increase in the Bacteroidetes/Firmicutes ratio and a decrease in Eubacterium rectale, Ruminococcus obeum, Lachnospiraceae bacterium and F. prausnitzii (in those with impaired glucose tolerance only) 227 . VSG also led to an increase in malabsorption due to loss of energy-rich fatty acids in the stool, impaired bile acid circulation 227 and resulted in greater capacity for metabolism of amino acids 219 . A human study compared gut microbial changes about 9 years after either RYGB or vertical banded gastroplasty (VBG), a predominantly restrictive operation 228 .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Proceedings of the 2017 ASPEN Research Workshop—Gastric Bypass: Role of the Gut

Jain

Roux

Puri

et al. 2018

J Parenter Enteral Nutr

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The goal of the National Institutes of Health-funded American Society for Parenteral and Enteral Nutrition 2017 research workshop (RW) "Gastric Bypass: Role of the Gut" was to focus on the exciting research evaluating gut-derived signals in modulating outcomes after bariatric surgery. Although gastric bypass surgery has undoubted positive effects, the mechanistic basis of improved outcomes cannot be solely explained by caloric restriction. Emerging data suggest that bile acid metabolic pathways, luminal contents, energy balance, gut mucosal integrity, as well as the gut microbiota are significantly modulated after bariatric surgery and may be responsible for the variable outcomes, each of which was rigorously evaluated. The RW served as a timely and novel academic meeting that brought together clinicians and researchers across the scientific spectrum, fostering a unique venue for interdisciplinary collaboration among investigators. It promoted engaging discussion and evolution of new research hypotheses and ideas, driving the development of novel ameliorative, therapeutic, and nonsurgical interventions targeting obesity and its comorbidities. Importantly, a critical evaluation of the current knowledge regarding gut-modulated signaling after bariatric surgery, potential pitfalls, and lacunae were thoroughly addressed.

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Section: Introductionsupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Proceedings of the 2017 ASPEN Research Workshop—Gastric Bypass: Role of the Gut

Jain

Roux

Puri

et al. 2018

J Parenter Enteral Nutr

View full text Add to dashboard Cite

show abstract

“…DNA study in a stool sample of T2D who separately undergone laparoscopic Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) surgery revealed more Firmicutes and Actinobacteria phyla and lesser Bacteroidetes phyla in RYGB group; unlikely more Bacteroidetes phyla found in SG group; similar Roseburia species was noticed in both groups [36].…”

Section: Reason Iii: Diabetes Specific Gut Microbiotamentioning

confidence: 99%

Gut Microbiota and Diabetes Mellitus - An Interlinkage

Vijayasimha

Prabhakar

2018

Asian J Pharm Clin Res

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In recent years, the curiosity to investigate the relationship between gut microbiota and diabetes development has increased. Evidence from previous studies suggests that gut microbiota manipulation may assure to prevent diabetes development in future, primarily in susceptible individuals. Here, we reviewed special gut microbiota types proposing development of Type 1 (T1D) and Type 2 diabetes (T2D) in humans and laboratory animals. The available data we found are still inconclusive and required more attention in discriminating specific groups of gut microbiomes strongly indicating T1D and T2D development or prevention. Further, we suggested for the first time to study the gut microbiota in different ways to find the root cause of diabetes development.

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“…A recent study 10 has compared changes in gut microbiome following both RYGB and sleeve gastrectomy (SG). At baseline (following a two-week weight reduction diet), no significant differences in gut microbiota composition was found.…”

mentioning

confidence: 99%

Obesity and the Microbiome - A Surgeon's Perspective

Raziel¹

2017

AOWMC

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Obesity is an enormous public health problem, arising from the abundance of food, eating behavior, and body regulation on energy intake, expenditure, and storage. Recent evidence suggests that the gut microbiota may play a role in obesity by increasing the host's energy-harvesting efficiency. Obesity surgery, a well-accepted tool for weight reduction, contributes to alterations in gut microbiota through anatomical changes and through modifications of dietary components. The mechanisms of the microbiome activity consist of modulating the host metabolism, inflammatory processes including insulin resistance, and by affecting the endocrine and the nervous systems.The type of bacteria present in the gut regulates fatty acid metabolism by using specific short chain fatty acids as metabolites. Bacterial fermentation of dietary fibers producing these fatty acids turns the dietary fibers into mediators for bacterial communication with the organs, thereby modulating the host metabolism. Bariatric surgery changes the ratio of microbiome components. Studies suggest that there is not only a starvation-like adaptation of the gut microbiota but also a change in the relative abundance of different bacteria that are associated with metabolic and inflammatory processes. These changes were found at three months post-surgery, and are persistent at longer follow-ups, indicating a stable gut modification.The literature review presented may suggest that specific analysis of the microbiota can help in selecting the preferred type of surgery and the prospect of surgery success in terms of long term weight reduction. We thought it would be beneficial for scientists interested in obesity to enrich their knowledge about the highlights of the relations between the microbiota and obesity, and more specifically with that of bariatric surgery.

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Differential Changes in Gut Microbiota After Gastric Bypass and Sleeve Gastrectomy Bariatric Surgery Vary According to Diabetes Remission

Abstract: Overall, RYGB produces greater and more predicted favourable changes in gut microbiota functional capacity than SG. An increase in Roseburia species was the only compositional change common to both types of surgery among those achieving diabetes remission.

Cited by 246 publications

References 35 publications

Proceedings of the 2017 ASPEN Research Workshop—Gastric Bypass: Role of the Gut

Proceedings of the 2017 ASPEN Research Workshop—Gastric Bypass: Role of the Gut

Gut Microbiota and Diabetes Mellitus - An Interlinkage

Obesity and the Microbiome - A Surgeon's Perspective

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