Differential CXCR4 expression on hematopoietic progenitor cells versus stem cells directs homing and engraftment

Bone marrow-inspired hydrogel/graphene composite scaffolds to support in vitro expansion of hematopoietic stem cells

“…This journal is © The Royal Society of Chemistry 2024 VLA-4, VLA-5, and HOXB4 expressions that play crucial roles in HSC homing and self-renewal [35][36][37][38] were examined. Compared to fresh isolated cells, the CXCR4 relative expression of HSCs cultured in the Gel-HA/GF composite scaffold, Gel-HA hydrogel, GF scaffold and 2D TCP culture system increased by 10.0-, 7.6-, 11.4-and 3.7-fold, respectively (Fig.…”

Clonal Hematopoiesis: Role in Hematologic Non-Hematologic

“… 75 Transplantation studies carried out in immunodeficient mice showed that intra-bone marrow transplantation of HSCs and HPCs, but not of LT-HSCs: the higher engraftment of HPCs compared to HSCs seems to be due to a higher expression of the CXCR4 receptor on HPCs compared to HSCs. 76 The removal of HPC and the transplantation of an HSC-enriched cell population intra-bone improved the engraftment HSCs. 76 Induction of a higher expression of CXCR4 on HSCs improves homing and engraftment of these cells.…”

“… 76 Induction of a higher expression of CXCR4 on HSCs improves homing and engraftment of these cells. 76 …”

“…76 The removal of HPC and the transplantation of an HSC-enriched cell population intra-bone improved the engraftment HSCs. 76 Induction of a higher expression of CXCR4 on HSCs improves homing and engraftment of these cells. 76 Aging of Hematopoietic Stem Cells.…”

“…76 Induction of a higher expression of CXCR4 on HSCs improves homing and engraftment of these cells. 76 Aging of Hematopoietic Stem Cells. Aging is associated with a decline and alterations of mature blood cells and there is evidence that a combination of intrinsic and extrinsic mechanisms is responsible for these changes.…”