Differential diagnosis of a diffuse sclerosis in an identified male skull (early 20th century Coimbra, Portugal): A multimethodological approach for the identification of osteosclerotic dysplasias in skeletonized individuals

Magalhães, Bruno M.; Catarino, Lídia; Carreiro, Inês; Gomes, Ricardo A.M.P.; Gaspar, Rosa Ramos; Matos, Vítor; Santos, Ana Luı́sa

doi:10.1016/j.ijpp.2021.06.002

International Journal of Paleopathology

2021

DOI: 10.1016/j.ijpp.2021.06.002

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Differential diagnosis of a diffuse sclerosis in an identified male skull (early 20th century Coimbra, Portugal): A multimethodological approach for the identification of osteosclerotic dysplasias in skeletonized individuals

Bruno M. Magalhães

Lídia Catarino

Inês Carreiro

et al.

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Cited by 4 publications

References 41 publications

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The Role of Fe, S, P, Ca, and Sr in Porous Skeletal Lesions: A Study on Non-adult Individuals Using pXRF

Gomes,

Catarino,

Santos

2024

Biol Trace Elem Res

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Portable X-ray fluorescence is a new tool in the study of human bone. This research aims to investigate if variations in bone elemental concentrations are related with porous skeletal lesions (PSLs). One hundred well-preserved non-adult skeletons aged 0–11 years were selected from the archaeological site Convent of São Domingos, Lisbon (18th–19th century). Measuring a standard reference material and calculating the technical error of measurement assured elemental data reliability. Moreover, measuring soil samples excluded possible contamination of bones with elements from the soil, except for Pb. Additionally, the Ca/P ratio indicates maintenance of bone integrity. Cribra cranii, orbitalia, humeralis, and femoralis were recorded as present/absent, and the estimated intra-/inter-observer errors were low. The multivariate analysis found higher odds of having cribra orbitalia (OR = 1.76; CI = 0.97–3.20) and cribra femoralis (OR = 1.42; CI = 0.73–2.74) in individuals with lower Fe and higher S. Furthermore, higher levels of P, Ca, and Sr increased the odds of individuals developing cribra femoralis (OR = 2.30; CI = 1.23–4.29). Age also correlated with increased odds of exhibiting cribra orbitalia (OR = 1.86; CI = 0.94–3.68), cribra femoralis (OR = 6.97; CI = 2.78–17.45), and cribra humeralis (OR = 8.32; CI = 2.71–25.60). These findings suggest a shared etiology for these three cribras, contrasting with the higher Fe levels in individuals with cribra cranii. Lower Fe and higher S levels in individuals with cribra suggest a complex etiology, possibly involving conditions like megaloblastic or chronic disease anemia(s). Age-related elemental changes support the hypothesis that age influences cribra frequencies. This study highlights PSL complexity and opens new avenues for research.

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The Role of Fe, S, P, Ca, and Sr in Porous Skeletal Lesions: A Study on Non-adult Individuals Using pXRF

Gomes,

Catarino,

Santos

2024

Biol Trace Elem Res

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Elemental analysis using portable X-ray fluorescence: Guidelines for the study of dry human bone

Gomes,

Santos,

Catarino

2024

International Journal of Paleopathology

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Metabolic bone disease in an extinct neotropical primate

Araújo,

Dantas,

Liparini

et al. 2025

International Journal of Paleopathology

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Differential diagnosis of a diffuse sclerosis in an identified male skull (early 20th century Coimbra, Portugal): A multimethodological approach for the identification of osteosclerotic dysplasias in skeletonized individuals

Cited by 4 publications

References 41 publications

The Role of Fe, S, P, Ca, and Sr in Porous Skeletal Lesions: A Study on Non-adult Individuals Using pXRF

The Role of Fe, S, P, Ca, and Sr in Porous Skeletal Lesions: A Study on Non-adult Individuals Using pXRF

Elemental analysis using portable X-ray fluorescence: Guidelines for the study of dry human bone

Metabolic bone disease in an extinct neotropical primate

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