Differential diagnostics of dementia type diseases

Reith, Wolfgang; Mühl-Benninghaus, Ruben

doi:10.1007/s00117-014-2799-z

Cited by 3 publications

(3 citation statements)

References 22 publications

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“…Inclusion criteria include (1) diagnosis of dementia or suspected dementia (based on the assessment of the objective ICD-10 criteria by employees and the examination of cognitive abilities with Mini-Mental State Examination [MMSE][45]), (2) Alzheimer disease, vascular dementia, or other primary dementia (all types caused by neurodegenerative or vascular diseases: eg, lewy body dementia or frontotemporal dementia [46]), (3) mild to moderate stage of dementia (MMSE 10-24), (4) age above 65 years, (5) walking ability of approximately 10 meters with or without walking aid, and (6) clearance by general practitioner.…”

Section: Methodsmentioning

confidence: 99%

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Effectiveness of a 16-Week Multimodal Exercise Program on Individuals With Dementia: Study Protocol for a Multicenter Randomized Controlled Trial

Trautwein¹,

Scharpf²,

Barisch‐Fritz³

et al. 2017

JMIR Res Protoc

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BackgroundThe increasing prevalence of dementia in the next decades is accompanied by various societal and economic problems. Previous studies have suggested that physical activity positively affects motor and cognitive skills in individuals with dementia (IWD). However, there is insufficient evidence probably related to several methodological limitations. Moreover, to date adequate physical activity interventions specifically developed for IWD are lacking.ObjectiveThis study aims to investigate the effectiveness of a multimodal exercise program (MEP) on motor and cognitive skills in IWD in a high-quality multicenter trial.MethodsA multicenter randomized controlled trial with baseline and postassessments will be performed. It is planned to enroll 405 participants with dementia of mild to moderate stage, aged 65 years and older. The intervention group will participate in a 16-week ritualized MEP especially developed for IWD. The effectiveness of the MEP on the primary outcomes balance, mobility, and gait will be examined using a comprehensive test battery. Secondary outcomes are strength and function of lower limbs, activities of daily living, and cognition (overall cognition, language, processing speed, learning and memory, and visual spatial cognition).ResultsEnrollment for the study started in May 2015. It is planned to complete postassessments by the beginning of 2017. Results are expected to be available in the first half of 2017.ConclusionsThis study will contribute to enhancing evidence for the effects of physical activity on motor and cognitive skills in IWD. Compared to previous studies, this study is characterized by a dementia-specific intervention based on scientific knowledge, a combination of motor and cognitive tasks in the intervention, and high standards regarding methodology. Findings are highly relevant to influence the multiple motor and cognitive impairments of IWD who are often participating in limited physical activity.Trial RegistrationGerman Clinical Trials Register DRKS00010538; https://drks-neu.uniklinik-freiburg.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00010538 (Archived by WebCite at http://www.webcitation.org/6oVGMbbMD)

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Section: Methodsmentioning

confidence: 99%

“…Exclusion criteria include (1) secondary dementia (all types resulting from organic illness or injury: eg, toxic substances or brain injuries [46]), (2) other severe cognitive impairments, (3) other severe neurological disease, (4) other severely acute diseases, and (5) severe motor impairments.…”

Section: Methodsmentioning

confidence: 99%

Effectiveness of a 16-Week Multimodal Exercise Program on Individuals With Dementia: Study Protocol for a Multicenter Randomized Controlled Trial

Trautwein¹,

Scharpf²,

Barisch‐Fritz³

et al. 2017

JMIR Res Protoc

View full text Add to dashboard Cite

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“…Cognitive impairment can accompany Alzheimer’s disease, neurological injuries, psychiatric conditions, Parkinson’s disease, and genetic factors, among other causes ( 8 , 9 ). Given their etiological complexity, no cure currently exists for cognitive impairment and dementia.…”

Section: Introductionmentioning

confidence: 99%

Tourism experiences reduce the risk of cognitive impairment in the Chinese older adult: a prospective cohort study

Li,

Guo,

et al. 2023

Front. Public Health

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BackgroundGiven the etiological complexity of cognitive impairment, no effective cure currently exists for precise treatment of dementia. Although scholars have noted tourism’s potential role in managing cognitive impairment and mild dementia, more robust empirical investigation is needed in this area. This study aimed to examine the associations between tourism and cognitive impairment and dementia in older Chinese adults.MethodFrom a nationwide community-based cohort, 6,717 individuals aged ≥60 were recruited from 2011 to 2014, of whom 669 (9.96%) had had at least one tourism experience in the 2 years prior to enrollment. All the participants were then prospectively followed up until 2018. The association between tourism and cognitive impairment was examined by the Cox proportional hazards regression model. The adjusted hazard ratio (aHR) and its 95% confidence interval (CI) were calculated to evaluate the effect of tourism experience on cognitive impairment and dementia.ResultsA total of 1,416 individuals were newly diagnosed with cognitive impairment and 139 individuals with dementia onset during follow-up. The incidence of cognitive impairment was significantly lower among participants with tourism experiences (316.94 per 10,000 person-years) than those without such experiences (552.38 per 10,000 person-years). Cox regression showed that tourism decreased the risk of cognitive impairment (aHR = 0.69, 95% CI: 0.41–0.62) when adjusted for behavioral covariates and characteristics. Compared with participants without tourism experiences, those with 1, 2, and ≥3 tourism experiences had a lower risk of cognitive impairment with the aHRs of 0.72 (95% CI: 0.52–0.99), 0.65 (0.42–1.01), and 0.68 (0.44–0.98), respectively. Tourism experiences also reduced participants’ risk of dementia (aHR = 0.41, 95% CI: 0.19–0.89).ConclusionOur findings demonstrated associations between tourism and reduced risks of cognitive impairment and dementia in older Chinese adults. Thus, tourism could serve as a novel approach to dementia prevention.

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Research on nonstroke dementia screening and cognitive function prediction model for older people based on brain atrophy characteristics

Zhang

Zheng

et al. 2022

Brain and Behavior

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Background: Brain atrophy is an important feature in dementia and is meaningful to explore a brain atrophy model to predict dementia. Using machine learning algorithm to establish a dementia model and cognitive function model based on brain atrophy characteristics is unstoppable. Method:We acquired 157 dementia and 156 normal old people.s clinical information and MRI data, which contains 44 brain atrophy features, including visual scale assessment of brain atrophy and multiple linear measurement indexes and brain atrophy index. Five machine learning models were used to establish prediction models for dementia, general cognition, and subcognitive domains. Results:The extreme Gradient Boosting (XGBoost) model had the best effect in predicting dementia, with a sensitivity of 0.645, a specificity of 0.839, and the area under curve (AUC) of 0.784. In this model, the important brain atrophy features for predicting dementia were temporal horn ratio, cella media index, suprasellar cistern ratio, and the thickness of the corpus callosum genu. Conclusion:For nonstroke elderly people, the machine learning model based on clinical head MRI brain atrophy features had good predictive value for dementia, general cognitive impairment, immediate memory impairment, word fluency disorder, executive dysfunction, and visualspatial disorder.

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Differential diagnostics of dementia type diseases

Cited by 3 publications

References 22 publications

Effectiveness of a 16-Week Multimodal Exercise Program on Individuals With Dementia: Study Protocol for a Multicenter Randomized Controlled Trial

Effectiveness of a 16-Week Multimodal Exercise Program on Individuals With Dementia: Study Protocol for a Multicenter Randomized Controlled Trial

Tourism experiences reduce the risk of cognitive impairment in the Chinese older adult: a prospective cohort study

Research on nonstroke dementia screening and cognitive function prediction model for older people based on brain atrophy characteristics

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