Differential effects of electroconvulsive shock on the glutamate receptor mRNAs for NR2A, NR2B and mGluR5b

Watkins, Clare J.; Pei, Qi; Newberry, Nigel R.

doi:10.1016/s0169-328x(98)00211-3

Cited by 46 publications

(22 citation statements)

References 38 publications

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“…For example, antidepressant drugs produce a time-and dose-dependent change in the radioligand binding properties of the NMDA receptor (82 -91). These changes are present with all antidepressant classes (87) and may involve an alteration in the expression of NMDA-receptor subunits (92,93). Chronic antidepressant treatments can also alter NMDA-receptor function (94 -96).…”

Section: Glutamate and Depressionmentioning

confidence: 99%

The Role of Sigma Receptors in Depression

2005

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Abstract. Behavioral models used to test potential antidepressants have shown that ligands that bind to sigma receptors possess "antidepressant-like" properties. The focus of this review is to discuss the literature concerning sigma receptors and their ligands, with respect to their antidepressants properties. In addition to the behavioral data, we discuss electrophysiological and biochemical models demonstrating sigma receptors' ability to modulate important factors in the pathophysiology of depression and / or the mechanisms of action of antidepressants such as the serotonergic neurotransmission in the dorsal raphe nucleus (DRN) and the glutamatergic transmission in the hippocampus. We also discuss the significance of these two systems in the mechanism of action of antidepressants. Sigma ligands have potential as antidepressant medications with a fast onset of action as they produce a rapid modulation of the serotonergic system in the DRN and the glutamatergic transmission in the hippocampus. As these effects of sigma ligands may produce antidepressant properties by completely novel mechanisms of action, they may provide an alternative to the antidepressants currently available and may prove to be beneficial for treatment-resistant depressed patients.

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Section: Glutamate and Depressionmentioning

confidence: 99%

The Role of Sigma Receptors in Depression

2005

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“…ECT is known to induce changes in muscarinic and glutamatergic receptors [69], [116] potassium channel expression [83], microtubule-associated proteins [84], as well as modulate entorhinal-dentate projections excitability [36] and NPY transmission [64]. It is unclear if DBS and PNS stimulation protocols would induce similar long-term changes.…”

Section: F High-frequency Stimulation: Post-stimulation Mechanismsmentioning

confidence: 99%

Suppression and control of epileptiform activity by electrical stimulation: a review

2001

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“…30 Although the expression of mRNA for the NR1 subunit was unchanged in our study, 28 ECS treatment has been shown to alter the expression of mRNA for other NMDA receptor subunits. Watkins et al 31 found that chronic ECS treatment produced an acute increase in mRNA for both the NR2A and NR2B subunits of the NMDA receptor in the dentate gyrus, although only the NR2B increase was sustained 24 h later. The NR2 subunits appear to be important in determining the ion channel selectivity of the NMDA receptor and its calMolecular Psychiatry cium-dependent inactivation.…”

Section: Molecular Mechanisms Underlying the Ecs Effectmentioning

confidence: 99%

“…These changes are in the opposite direction to those caused by ECS treatment in the rat dentate gyrus. 31 As with ECS treatment, antidepressant drugs produce an increase in the levels of mRNA for CREB and BDNF in the hippocampus. 36,37 These changes in postsynaptic receptor signal transduction mechanisms may have arisen through the activation of a variety of different receptors, including serotonergic and adrenergic postsynaptic receptors.…”

Section: Molecular Mechanisms Underlying the Antidepressant Drug Effectmentioning

confidence: 99%

Antidepressant mechanisms: functional and molecular correlates of excitatory amino acid neurotransmission

Stewart

Reid

2002

Mol Psychiatry

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Specific targeting of the serotonergic and noradrenergic systems for the development of antidepressant compounds has resulted in drugs with more favourable side-effect profiles but essentially no greater efficacy than those compounds discovered more than 40 years ago. Alternative targets are now being considered in the hope that they will have a faster onset of action and be useful for those patients currently unresponsive to conventional treatments. Excitatory amino acid neurotransmission has been attributed various roles in both normal and abnormal brain function. The N-methyl-D-aspartate receptor in particular has long been postulated to play a role in the formation of memories. Major depressive disorder is characterised by alterations in cognitive function, as well as affect. Although there is evidence that early adverse events and stress can have a causal influence on depression, the underlying neurobiology of the disorder is poorly understood. This review will document current evidence for the involvement of excitatory amino acid neurotransmission in the pathophysiology of the affective disorders. The preclinical literature suggests that both electroconvulsive stimulation and antidepressant drugs can affect hippocampal long-term potentiation and the expression of excitatory amino acid receptor subtypes. Exposing animals to stress, including the kind that produces learned helplessness, can also affect synaptic plasticity in the hippocampus. There is clinical evidence that patients with chronic depression have structural brain abnormalities, including hippocampal atrophy, and a preliminary study has shown that an N-methyl-D-aspartate receptor antagonist may have antidepressant efficacy. Molecular Psychiatry (2002) 7, S15-S22.

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Differential effects of electroconvulsive shock on the glutamate receptor mRNAs for NR2A, NR2B and mGluR5b

Cited by 46 publications

References 38 publications

The Role of Sigma Receptors in Depression

The Role of Sigma Receptors in Depression

Suppression and control of epileptiform activity by electrical stimulation: a review

Antidepressant mechanisms: functional and molecular correlates of excitatory amino acid neurotransmission

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