Differential effects of estradiol on carotid artery inflammation when administered early versus late after surgical menopause

Sophonsritsuk, Areepan; Appt, Susan E.; Clarkson, Thomas B.; Shively, Carol A.; Espeland, Mark A.; Register, Thomas C.

doi:10.1097/gme.0b013e31827461e0

Cited by 25 publications

(20 citation statements)

References 39 publications

(47 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For cortisol measurements, a morning blood samples were taken within 5 min of capture and sedation with ketamine hydrochloride (10 mg/kg) and used with commercially available coated tube RIA kit from Diasource (Louvain-la-Neuve, Belgium). Total plasma cholesterol (TPC) and HDL were measured as previously described ( Sophonsritsuk et al, 2013 ). In brief, TPC and HDL were determined in the Wake Forest Primate Center Clinical Chemistry Laboratory using ACE cholesterol and ACE HDL-C reagents and ACE ALERA autoanalyzer from Alfa Wasserman Diagnostic Technologies (West Caldwell, NJ).…”

Section: Methodsmentioning

confidence: 99%

Consumption of Mediterranean versus Western Diet Leads to Distinct Mammary Gland Microbiome Populations

et al. 2018

Self Cite

View full text Add to dashboard Cite

SUMMARY Recent identification of a mammary gland-specific microbiome led to studies investigating bacteria populations in breast cancer. Malignant breast tumors have lower Lactobacillus abundance compared with benign lesions, implicating Lactobacillus as a negative regulator of breast cancer. Diet is a main determinant of gut microbial diversity. Whether diet affects breast microbiome populations is unknown. In a non-human primate model, we found that consumption of a Western or Mediterranean diet modulated mammary gland microbiota and metabolite profiles. Mediterranean diet consumption led to increased mammary gland Lactobacillus abundance compared with Western diet-fed monkeys. Moreover, mammary glands from Mediterranean diet-fed monkeys had higher levels of bile acid metabolites and increased bacterial-processed bioactive compounds. These data suggest that diet directly influences microbiome populations outside the intestinal tract in distal sites such as the mammary gland. Our study demonstrates that diet affects the mammary gland microbiome, establishing an alternative mechanistic pathway for breast cancer prevention.

show abstract

Section: Methodsmentioning

confidence: 99%

Consumption of Mediterranean versus Western Diet Leads to Distinct Mammary Gland Microbiome Populations

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…In the present study, we chose to address some of these issues in climacteric women. Menopause is associated with chronic inflammation and has major implications for CAD development [24, 25] and associated lipid disorders [26]. HPV incidence is also higher in this group [27] and might act synergistically with some of these factors to aggravate its cardiovascular risk.…”

Section: Discussionmentioning

confidence: 99%

Human Papillomavirus and Coronary Artery Disease in Climacteric Women: Is There an Association?

Brito

Corrêa

et al. 2019

The Scientific World Journal

View full text Add to dashboard Cite

Background. Cardiovascular diseases are leading causes of death worldwide. Recent studies suggest that infection by some viruses, including the human papillomavirus (HPV), may increase the risk of developing atheromatous lesions on coronary arteries. However, there is a lack of data regarding the possible association between HPV infection and coronary artery disease (CAD) in women. Objective. To investigate whether HPV infection is associated with the occurrence of CAD among climacteric women. Methods. The presence of CAD and cervical HPV DNA was investigated in 52 climacteric women. Social and demographic variables and metabolic profiles were also investigated. Results. Among 27 women with CAD, 16 were positive for HPV, whereas 11 were negative. The presence of cervical HPV was strongly associated with CAD, after adjusting for demographic variables, health and sexual behaviors, comorbidities, and known cardiovascular risk factors. HPV-positive women showed a greater likelihood of having CAD (odds ratio [OR] = 3.74; 95% confidence interval [CI]: 1.16 to 11.96) as compared with HPV-negative women, particularly those infected with high-risk HPV types (OR = 4.90; 95% CI: 1.26 to 19.08). Conclusion. These results support the hypothesis that HPV infection might be associated with CAD among climacteric women, though further studies are needed to investigate the mechanisms involved.

show abstract

“…30 Experimental studies in animals have also provided support for this association. 31,32 Although, the mechanism by which aging and longer periods of estrogen deprivation affect HRT responses is unclear, there are suggestions that estrogen has a moreproinflammatory effect with aging. 33 It is difficult to interpret the current study findings in context of the timing hypothesis, because a surrogate marker of atherosclerosis was used, and event rates were compared using a cross-sectional approach, but the findings suggest that, if HRT is initiated early and continued for longer than 15 years, an association with low CAC will remain.…”

Section: Discussionmentioning

confidence: 99%

Long‐Term Hormone Replacement Therapy Is Associated with Low Coronary Artery Calcium Levels in a Cohort of Older Women: The Age, Gene/Environment Susceptibility—Reykjavik Study

Guðmundsson

Aspelund

Sigurðsson

et al. 2016

J American Geriatrics Society

View full text Add to dashboard Cite

Background The long term effect of postmenopausal hormone replacement therapy (HRT) on atherosclerosis and cardiovascular health is controversial. Coronary Artery Calcium (CAC) is an established marker of atherosclerotic plaque burden. Objectives To assess the relationship between HRT and CAC. Design/setting Cross sectional assessment in an established population based cohort in Reykjavik, Iceland. Participants 2867 women (mean age 76±5 years) who had completed questionnaires on HRT use. Measurements The CAC by Computed Tomography was used as outcome variable and compared between women with history of HRT or had never used HRT, and was analysed according to age, length of use, and time from menopause when HRT was initiated. Results 872 (30.4%) of the 2867 participants had used HRT and 312 (10.9%) were current users. After adjustment for age, other late life variables, and a propensity score based on midlife data for HRT use as observed in late life, the CAC showed significant negative associations with history and length of HRT use. This association was evident in all age categories. When the duration of HRT use was more than 15 years, the median coronary calcium was less than 50% of that observed in never users. The lowest CAC was observed in those who started HRT within five years after menopause. The prevalence of coronary events was comparable in both groups. Conclusion Long term HRT shows a strong association with lower CAC in comparison with women who had never used HRT. The negative association between HRT and CAC was linear with the duration of HRT and evident in all age groups of older women.

show abstract

Differential effects of estradiol on carotid artery inflammation when administered early versus late after surgical menopause

Cited by 25 publications

References 39 publications

Consumption of Mediterranean versus Western Diet Leads to Distinct Mammary Gland Microbiome Populations

Consumption of Mediterranean versus Western Diet Leads to Distinct Mammary Gland Microbiome Populations

Human Papillomavirus and Coronary Artery Disease in Climacteric Women: Is There an Association?

Long‐Term Hormone Replacement Therapy Is Associated with Low Coronary Artery Calcium Levels in a Cohort of Older Women: The Age, Gene/Environment Susceptibility—Reykjavik Study

Contact Info

Product

Resources

About