Differential effects of experimental hyperthyroidism on declined immunity of broiler chicken

Khilji, Muhammad Saad; Sandhu, Mansur A.; Yousaf, Muhammad; Saeed, Abdalla A.; Rehman, Habib; Zaneb, Hafsa; Rashid, Muhammad Afzal

doi:10.1111/jpn.12861

Cited by 3 publications

(3 citation statements)

References 29 publications

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“…Dogs with GBM have a high incidence of concurrent hyperadrenocorticism, hypothyroidism, and hyperlipidemia . These metabolic disturbances cause immune dysregulation in various species and may contribute to the development of, or magnify, cholecystitis (infectious and sterile) in dogs with GBM . Alternatively, it has been suggested that GBMs in dogs may be a consequence of primary chronic cholecystitis .…”

Section: Discussionmentioning

confidence: 99%

Prevalence and impact of cholecystitis on outcome in dogs with gallbladder mucocele

Rogers

Jaffey

Graham

et al. 2019

J Vet Emergen Crit Care

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Background: Gallbladder mucocele is a potentially life-threatening extrahepatic biliary disease in dogs. The primary aims of this study were to evaluate the prevalence of cholecystitis in dogs with gross and histopathologically confirmed gallbladder mucocele and to investigate if there is an association between cholecystitis, including its subtypes (eg, acute, acute on chronic, with necrosis, chronic), and survival. Our secondary objective was to evaluate if there is an association between cholecystitis and intraoperative bacteriological culture positivity.Key Findings: Two hundred nineteen dogs with gallbladder mucocele were included in this multiinstitutional retrospective study, of which 63 (28.8%) dogs had histopathological evidence of cholecystitis. The most common forms of cholecystitis were acute on chronic (n = 22/63, 34.9%) and with necrosis (n = 20, 31.7%). Thirty-one (14.1%) dogs had growth of at least 1 bacterial isolate; however, 88.7% had antimicrobials administered within the 48 hours before surgery or intraoperatively. There was not an association between cholecystitis or its subtypes and survival. Furthermore, there was not an association between cholecystitis and intraoperative bacteriological culture positivity. A total of 38 (17.4%) dogs either died or were euthanized during hospitalization.Significance: Cholecystitis is a common comorbidity in dogs with gallbladder mucocele but was not associated with decreased survival.

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Section: Discussionmentioning

confidence: 99%

Prevalence and impact of cholecystitis on outcome in dogs with gallbladder mucocele

Rogers

Jaffey

Graham

et al. 2019

J Vet Emergen Crit Care

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“…Stressors often cause dynamic changes in the hormones in the hypothalamic-pituitary-adrenal (HPA) axis ( Khilji et al, 2018 ). The activation of the HPA axis in broilers under heat stress conditions leads to elevated plasma glucocorticoid corticosterone ( Quinteiro-Filho et al, 2012 ).…”

Section: Discussionmentioning

confidence: 99%

Effect of dietary resveratrol supplementation on growth performance, antioxidant capacity, intestinal immunity and gut microbiota in yellow-feathered broilers challenged with lipopolysaccharide

Xiong

et al. 2022

Front. Microbiol.

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Resveratrol (RES) displays strong antioxidant and anti-inflammatory properties in protecting the animals from various stressors and inflammatory injuries, but its interrelationship with the gut microbiota remained largely unclear. This study was carried out to investigate the effects of dietary RES supplementation on growth performance, antioxidant capacity, intestinal immunity and gut microbiota in yellow-feathered broilers challenged by lipopolysaccharide (LPS). A total of 240 yellow-feathered broilers were randomly assigned to four treatment groups in a 2 × 2 factorial design. The broilers were fed with the control diet or control diet supplemented with 400 mg/kg RES, followed by challenge with LPS or the same amount of saline. Dietary RES supplementation significantly alleviated the decreases in the final body weight (BW), average daily gain (ADG), and ADFI induced by LPS (P < 0.05). LPS challenge significantly increased plasma concentrations of triglyceride, high-density lipoprotein cholesterol (HDL-C), aspartate aminotransferase (AST), and cortisol levels, but decreased triiodothyronine (T3) and insulin levels (P < 0.05). Dietary supplementation with RES significantly reversed the elevated creatinine concentrations and the decreased concentrations of T3 and insulin caused by LPS (P < 0.05). Moreover, dietary RES supplementation significantly increased plasma total antioxidant capacity (T-AOC) and catalase (CAT) activities and superoxide dismutase (SOD) and T-AOC activities in jejunal mucosa and reduced malondialdehyde (MDA) concentration in the plasma (P < 0.05). The reduction in the villus height to crypt depth ratio in duodenum, jejunum and ileum and the shortening of villus height in jejunum and ileum caused by LPS were also alleviated by RES treatment (P < 0.05). Furthermore, the increased concentrations of intestinal tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and IL-1β caused by LPS were significantly decreased by RES treatment (P < 0.05). Dietary RES treatment increased the mRNA expression of claudin-1, claudin-5, occludin, and zonula occludens-1 (ZO-1), and decreased mRNA expression of IL-1β, IL-8, IL-17, and TNF-α after LPS challenge (P < 0.05). Dietary RES treatments significantly decreased the dominance of cecal microbiota, and increased the Pieiou-e and Simpson index. Moreover, dietary RES supplementation increased relative abundance of UCG_ 009, Erysipelotrichaceae, Christensenellaceae_R-7_group, Anaerotruncus, RF39, and Ruminococcus while decreasing the abundance of Alistipes at genus level. Spearman correlation analysis revealed that the microbes at the order and genus levels significantly correlated with indicators of growth performance, antioxidant capacity, and intestinal health. Collectively, dietary supplementation with 400 mg/kg RES could improve growth performance and antioxidant capacity, and modulate intestinal immunity in yellow-feathered broilers challenged by LPS at early stage, which might be closely associated with the regulation of gut microbiota community composition.

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“…The effect of BHA on some hematological characteristics can also be attributed to thyroid hormones. These hormones play an essential role in the progress of lymphoid organs and the arranging of immune assignment in birds and raise the number of lymphocytes, phagocytes, IgM, and IgG (14), as indicated by Keshavarz et al (15) to giving thyroxine at a concentration of 0.3 mg/bird daily to laying hens at the age of 47 weeks for 14 weeks led to an increase in the number of white and red cells, and this was identical to the results of this study. The increase in hemoglobin and packed cell volume is due to a direct relationship with an upraise in the number of RBC.…”

Section: Discussionmentioning

confidence: 99%

Effect of dietary BHA supplementation on certain physiological values in broiler chicken

Hameed

Maty

Hassan

2022

IJVS

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Butylated hydroxyl anisole (BHA) is manufactured from a mixture of two isomeric organic compounds, 2-tertiary-butyl-4-hydroxyanisole and 3-tert-butyl-4-hydroxyanisole, and is widely used in poultry feed as a phenolic free radical scavenger. The current search investigated the impact of different doses of BHA on some hematological and hormonal features of broiler. Fifty-four one-day-old birds were utilized in this study randomly divided into three groups, the control group was given a standard ratio, the 2 ed group was given a standard diet filled up with BHA at a rate of 2.5 mg/kg feed, and the 3 rd group was given a standard ration fill up with BHA at a rate of 5 mg/kg feed by 18 birds/group, each with three replicates (6 birds/ repeated cycle). The study included three age stages (15, 30, and 45) days. The results showed a significant rise in RBC, WBC, lymphocytes, MCH, SOD, and CAT for the two groups of BHA during 30 and 45 days of treatment compared with the control with a significant improvement in the stress index, as well as a significant decrease in MCV during the three periods of treatment. Supplementation with BHA in both doses caused a significant rise in T3 and T4 during 45 days of the study compared with the control group. We deduce from this research that adding BHA to the poultry diets improved physiological and hormonal characteristics due to its ability to scavenge free radicals. It promotes significant health and growth.

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Differential effects of experimental hyperthyroidism on declined immunity of broiler chicken

Cited by 3 publications

References 29 publications

Prevalence and impact of cholecystitis on outcome in dogs with gallbladder mucocele

Prevalence and impact of cholecystitis on outcome in dogs with gallbladder mucocele

Effect of dietary resveratrol supplementation on growth performance, antioxidant capacity, intestinal immunity and gut microbiota in yellow-feathered broilers challenged with lipopolysaccharide

Effect of dietary BHA supplementation on certain physiological values in broiler chicken

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