Differential Expression and Localization of Decorin in Human Choriodecidual Membrane during Preterm and Term Pregnancy

Ogita, Kazuhide; Kimura, Tadashi; Nakamura, Hitomi; Koyama, Shinsuke; Tsujie, Tomoko; Tomiie, Mari; Tsutsui, Tateki; Shimoya, Koichiro; Wada, Yoshinao; Koyama, Masayasu; Nomura, Shosaku; Murata, Yuji

doi:10.1111/j.1600-0897.2004.00143.x

Cited by 8 publications

(8 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This finding was consistent with increased quantities of leukocyte elastase and MMP-9, which degrade collagen and DCN, in the cervical membranes [ 78 , 81 , 82 ]. Considering the upregulation of cyclooxygenase (COX)-2 in term fetal membranes [ 83 ], it has been suggested that initiation of labor starts in the choriodecidual membranes [ 84 ]. DCN and collagen were plentiful in the fibroblastic portion of the chorion [ 78 ], with most DCN mRNA localized in decidual cells for the choriodecidual membranes [ 84 ].…”

Section: Distribution and Functions Of Dcn In The Pregnant Uterus And The Placentamentioning

confidence: 99%

“…Considering the upregulation of cyclooxygenase (COX)-2 in term fetal membranes [ 83 ], it has been suggested that initiation of labor starts in the choriodecidual membranes [ 84 ]. DCN and collagen were plentiful in the fibroblastic portion of the chorion [ 78 ], with most DCN mRNA localized in decidual cells for the choriodecidual membranes [ 84 ]. DCN transcription in the choriodecidual membranes was greater after term vaginal delivery than preterm delivery but lower than before labor.…”

Section: Distribution and Functions Of Dcn In The Pregnant Uterus And The Placentamentioning

confidence: 99%

See 1 more Smart Citation

Roles of Two Small Leucine-Rich Proteoglycans Decorin and Biglycan in Pregnancy and Pregnancy-Associated Diseases

Halari

Zheng

Lala

2021

IJMS

View full text Add to dashboard Cite

Two small leucine-rich proteoglycans (SLRP), decorin and biglycan, play important roles in structural–functional integrity of the placenta and fetal membranes, and their alterations can result in several pregnancy-associated diseases. In this review, we briefly discuss normal placental structure and functions, define and classify SLRPs, and then focus on two SLRPs, decorin (DCN) and biglycan (BGN). We discuss the consequences of deletions/mutations of DCN and BGN. We then summarize DCN and BGN expression in the pregnant uterus, myometrium, decidua, placenta, and fetal membranes. Actions of these SLRPs as ligands are then discussed in the context of multiple binding partners in the extracellular matrix and cell surface (receptors), as well as their alterations in pathological pregnancies, such as preeclampsia, fetal growth restriction, and preterm premature rupture of membranes. Lastly, we raise some unanswered questions as food for thought.

show abstract

Section: Distribution and Functions Of Dcn In The Pregnant Uterus And The Placentamentioning

confidence: 99%

Section: Distribution and Functions Of Dcn In The Pregnant Uterus And The Placentamentioning

confidence: 99%

Roles of Two Small Leucine-Rich Proteoglycans Decorin and Biglycan in Pregnancy and Pregnancy-Associated Diseases

Halari

Zheng

Lala

2021

IJMS

View full text Add to dashboard Cite

show abstract

“…Although it is not yet definitively established whether functional progesterone withdrawal is indeed a pivotal event in the human parturition cascade [5], all the preceding elements point to the fact that transcriptome studies of the myometrium, fetal membranes or placenta, should be a valuable approach to decipher the mechanisms involved in human parturition. In the course of the last 6 years, a number of transcriptomic studies on the preterm versus term pregnant human uterus [6-12] or fetal membranes [13-17] have been published.…”

Section: Introductionmentioning

confidence: 99%

Functional genomics of the pregnant uterus: from expectations to reality, a compilation of studies in the myometrium

Breuiller-Fouché

Charpigny

Germain

2007

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

BackgroundStudies on the human myometrium have reported on different microarrays containing different sets of genes or ESTs. However each study profiled only a small number of patients due to various constraints. More profiling information would be an addition to our knowledge base of parturition.MethodsWe compiled from five human studies, transcriptional differences between the non pregnant myometrium (NP), preterm myometrium (PTNIL), term myometrium not in labor (TNIL) and term myometrium in labor (TIL). Software modules developed by the Draghici's group at Wayne State University (Detroit, MI, USA) were used to propose a hierarchical list of several KEGG pathways most likely adjusted to changes observed in microarray experiments.ResultsThe differential expression of 118 genes could be dispatched in 14 main KEGG pathways that were the most representative of the changes seen in NP and PTNIL, versus TNIL or TIL. Despite the potential of multiple pitfalls inherent to the use of the microarray technology, gene module analysis of the myometrial transcriptome reveals the activation of precise signaling pathways, some of which may have been under evaluated.ConclusionThe remodelling and maturation processes that the uterus undergoes in pregnancy appear clearly as phenomena which last during the full course of gestation. It is attested by the nature of the main signaling pathways represented, in the comparison of the PTNIL versus TNIL uterus. Comparatively, the onset of labor is a phenomenon which remains less well characterized by these methods of analysis, possibly because it is a phenomenon occurring in too short a window to have been grasped by the studies carried out up to now.

show abstract

“…Cervical remodeling (including softening, ripening, dilation and labor) associated with PTD is related to collagen solubility [46-49]. Since, cervix is composed of extracellular matrix components such as collagen, elastin, proteoglycans and others, systemic effects can influence cervical remodeling [46,47].…”

Section: Discussionmentioning

confidence: 99%

Early pregnancy peripheral blood gene expression and risk of preterm delivery: a nested case control study

Enquobahrie

Williams

Qiu

et al. 2009

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

BackgroundPreterm delivery (PTD) is a significant public health problem associated with greater risk of mortality and morbidity in infants and mothers. Pathophysiologic processes that may lead to PTD start early in pregnancy. We investigated early pregnancy peripheral blood global gene expression and PTD risk.MethodsAs part of a prospective study, ribonucleic acid was extracted from blood samples (collected at 16 weeks gestational age) from 14 women who had PTD (cases) and 16 women who delivered at term (controls). Gene expressions were measured using the GeneChip® Human Genome U133 Plus 2.0 Array. Student's T-test and fold change analysis were used to identify differentially expressed genes. We used hierarchical clustering and principle components analysis to characterize signature gene expression patterns among cases and controls. Pathway and promoter sequence analyses were used to investigate functions and functional relationships as well as regulatory regions of differentially expressed genes.ResultsA total of 209 genes, including potential candidate genes (e.g. PTGDS, prostaglandin D2 synthase 21 kDa), were differentially expressed. A set of these genes achieved accurate pre-diagnostic separation of cases and controls. These genes participate in functions related to immune system and inflammation, organ development, metabolism (lipid, carbohydrate and amino acid) and cell signaling. Binding sites of putative transcription factors such as EGR1 (early growth response 1), TFAP2A (transcription factor AP2A), Sp1 (specificity protein 1) and Sp3 (specificity protein 3) were over represented in promoter regions of differentially expressed genes. Real-time PCR confirmed microarray expression measurements of selected genes.ConclusionsPTD is associated with maternal early pregnancy peripheral blood gene expression changes. Maternal early pregnancy peripheral blood gene expression patterns may be useful for better understanding of PTD pathophysiology and PTD risk prediction.

show abstract

Differential Expression and Localization of Decorin in Human Choriodecidual Membrane during Preterm and Term Pregnancy

Abstract: These results suggest that dynamically increased expression of decorin in the choriodecidual membrane during parturition may be a part of the uterine preparation for labor.

Cited by 8 publications

References 33 publications

Roles of Two Small Leucine-Rich Proteoglycans Decorin and Biglycan in Pregnancy and Pregnancy-Associated Diseases

Roles of Two Small Leucine-Rich Proteoglycans Decorin and Biglycan in Pregnancy and Pregnancy-Associated Diseases

Functional genomics of the pregnant uterus: from expectations to reality, a compilation of studies in the myometrium

Early pregnancy peripheral blood gene expression and risk of preterm delivery: a nested case control study

Contact Info

Product

Resources

About