Differential expression of bone morphogenetic protein 5 in human lung squamous cell carcinoma and adenocarcinoma

Abstract

Bone morphogenetic proteins (BMPs) play important roles in tumor cell proliferation, metastasis, and invasion. However, the expression patterns of BMPs in patients with non-small-cell lung cancer (NSCLC) and their correlations with NSCLC pathogenesis have not been examined yet. In this study, the mRNA levels of BMP family members in NSCLC tissues were analyzed and results showed that the mRNA levels of BMP5 and BMP7 were significantly down-regulated and up-regulated, respectively, in tumor tissues compared with those in the corresponding noncancerous tissues. Interestingly, the mRNA level of BMP5 was significantly higher in lung adenocarcinoma tissues than that in lung squamous cell carcinoma tissues. Furthermore, results from immunohistochemistry analysis confirmed stronger expression of BMP5 protein in lung adenocarcinoma than in lung squamous cell carcinoma. Our findings suggested that BMP5 might be a potential prognostic biomarker or therapeutic target for patients with NSCLC.

The depletion of PinX1 involved in the tumorigenesis of non-small cell lung cancer promotes cell proliferation via p15/cyclin D1 pathway

“…The phosphorylated Smad1/5/8 together with Smad4 translocated into nucleus and control cycle progression [37]. It has been reported that the mRNA levels of BMP5 was significantly decreased in NSCLC tissues [38]. In this study, the changes of downstream protein BMP5 correlated with PinX1-stimulated cell proliferation.…”

An Immune-Related Signature Predicts Survival in Patients With Lung Adenocarcinoma

“…From this, a prognostic prediction model was constructed, the RiskScore of patients was calculated, and prediction and verification were also carried out. Among all 14 prognosis-specific immunerelated genes, 9 (e.g., PSMD11, PPIA, MIF, BMP5, DKK1, PDGFB, ANGPTL4, IL1R2, and THRB) (26)(27)(28)(29)(30)(31)(32)(33)(34) have been reported to be involved in the immune microenvironmentassociated pathogenesis of lung adenocarcinoma or suggested to be significant predictors of recurrence-free or overall survival. This implies that our bioinformatics analysis using TCGA and ImmPort cohorts has prognostic value.…”

Non‑small-cell lung cancer pathological subtype‑related gene selection and bioinformatics analysis based on gene expression profiles

“…Zhao et al (22) demonstrated that CTDSPL2, as a Smad phosphatase, plays a critical role in bone morphogenetic protein (BMP)-induced signaling and cellular functions. Experimental evidence demonstrated that the mRNA level of BMP5 was significantly higher in ADC tissues compared with that in SCC tissues, and the immunohistochemistry analysis confirmed this result at the protein level (23). However, a correlation between the CTDSPL2 expression level and the occurrence of NSCLC has not been reported to date; it may be a novel biomarker of NSCLC development and progression.…”