Differential Expression of Cyclic AMP-Response Element Binding
                    Protein Zhangfei (CREBZF) in the Mouse Testis during Postnatal
                    Development

Jang, Hoon

doi:10.12717/dr.2018.22.1.065

Cited by 2 publications

(2 citation statements)

References 26 publications

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“…23,26,27 Based on the above characteristics, several additional studies have shown that CREBZF is widely involved in physiological processes such as metabolism, [28][29][30][31][32] cancers, [33][34][35][36][37] apoptosis, [38][39][40] autophagy, 41 and unfolded protein response (UPR). [42][43][44][45] In recent years, we 40,46,47 and others [48][49][50] have validated the…”

Section: Introductionmentioning

confidence: 85%

“…Based on the above characteristics, several additional studies have shown that CREBZF is widely involved in physiological processes such as metabolism, 28–32 cancers, 33–37 apoptosis, 38–40 autophagy, 41 and unfolded protein response (UPR) 42–45 . In recent years, we 40,46,47 and others 48–50 have validated the expression pattern of CREBZF in the gonads, indicating that CREBZF plays important roles in gametogenesis, embryo implantation, and steroid hormonal regulation.…”

Section: Introductionmentioning

confidence: 95%

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Androgen synthesis cell‐specific CREBZF deficiency alters adrenal cortex steroid secretion and develops behavioral abnormalities in adult male mice

Niu,

Li,

Zhang

et al. 2024

The FASEB Journal

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The global challenge of male infertility is escalating, notably due to the decreased testosterone (T) synthesis in testicular Leydig cells under stress, underscoring the critical need for a more profound understanding of its regulatory mechanisms. CREBZF, a novel basic region‐leucine zipper transcription factor, regulates testosterone synthesis in mouse Leydig cells in vitro; however, further validation through in vivo experiments is essential. Our study utilized Cyp17a1‐Cre to knock out CREBZF in androgen‐synthesis cells and explored the physiological roles of CREBZF in fertility, steroid hormone synthesis, and behaviors in adult male mice. Conditional knockout (cKO) CREBZF did not affect fertility and serum testosterone level in male mice. Primary Leydig cells isolated from CREBZF‐cKO mice showed impaired testosterone secretion and decreased mRNA levels of Star, Cyp17a1, and Hsd3b1. Loss of CREBZF resulted in thickening of the adrenal cortex, especially X‐zone, with elevated serum corticosterone and dehydroepiandrosterone levels and decreased serum dehydroepiandrosterone sulfate levels. Immunohistochemical staining revealed increased expression of StAR, Cyp11a1, and 17β‐Hsd3 in the adrenal cortex of CREBZF‐cKO mice, while the expression of AR was significantly reduced. Along with the histological changes and abnormal steroid levels in the adrenal gland, CREBZF‐cKO mice showed higher anxiety‐like behavior and impaired memory in the elevated plus maze and Barnes maze, respectively. In summary, CREBZF is dispensable for fertility, and CREBZF deficiency in Leydig cells promotes adrenal function in adult male mice. These results shed light on the requirement of CREBZF for fertility, adrenal steroid synthesis, and stress response in adult male mice, and contribute to understanding the crosstalk between testes and adrenal glands.

show abstract

Section: Introductionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 95%

Androgen synthesis cell‐specific CREBZF deficiency alters adrenal cortex steroid secretion and develops behavioral abnormalities in adult male mice

Niu,

Li,

Zhang

et al. 2024

The FASEB Journal

View full text Add to dashboard Cite

show abstract

Emerging Role of SMILE in Liver Metabolism

Sadasivam

Radhakrishnan

Choi

et al. 2023

IJMS

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Small heterodimer partner-interacting leucine zipper (SMILE) is a member of the CREB/ATF family of basic leucine zipper (bZIP) transcription factors. SMILE has two isoforms, a small and long isoform, resulting from alternative usage of the initiation codon. Interestingly, although SMILE can homodimerize similar to other bZIP proteins, it cannot bind to DNA. As a result, SMILE acts as a co-repressor in nuclear receptor signaling and other transcription factors through its DNA binding inhibition, coactivator competition, and direct repression, thereby regulating the expression of target genes. Therefore, the knockdown of SMILE increases the transactivation of transcription factors. Recent findings suggest that SMILE is an important regulator of metabolic signals and pathways by causing changes in glucose, lipid, and iron metabolism in the liver. The regulation of SMILE plays an important role in pathological conditions such as hepatitis, diabetes, fatty liver disease, and controlling the energy metabolism in the liver. This review focuses on the role of SMILE and its repressive actions on the transcriptional activity of nuclear receptors and bZIP transcription factors and its effects on liver metabolism. Understanding the importance of SMILE in liver metabolism and signaling pathways paves the way to utilize SMILE as a target in treating liver diseases.

show abstract

Differential Expression of Cyclic AMP-Response Element Binding Protein Zhangfei (CREBZF) in the Mouse Testis during Postnatal Development

Cited by 2 publications

References 26 publications

Androgen synthesis cell‐specific CREBZF deficiency alters adrenal cortex steroid secretion and develops behavioral abnormalities in adult male mice

Androgen synthesis cell‐specific CREBZF deficiency alters adrenal cortex steroid secretion and develops behavioral abnormalities in adult male mice

Emerging Role of SMILE in Liver Metabolism

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