Differential expression of cyclin G2, cyclin-dependent kinase inhibitor 2C and peripheral myelin protein 22 genes during adipogenesis

Zhang, J.; Suh, Young Ho; Choi, Young Min; Ahn, Jinsoo; Davis, Michael; Lee, Kichoon

doi:10.1017/s1751731114000469

Cited by 11 publications

(12 citation statements)

References 36 publications

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“…For analyzing tissue distribution pattern of gene expression in 12 male mouse tissues and 10 man tissues, GDS3142 for mice and GDS596 for humans were downloaded and sorted (Tables 1 and 2) as described in our previous reports [9, 10]. Also, gene expression patterns in mouse sperm cells (GDS2390), developing mouse testis (GDS605, GDS606 and GDS607), semen samples collected from 14 teratozoospermic individuals aged 21–57 (GDS2697), and polyubiquitin knockout mice (GDS3906) were examined.…”

Section: Methodsmentioning

confidence: 99%

Comparative expression profiling of testis-enriched genes regulated during the development of spermatogonial cells

et al. 2017

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The testis has been identified as the organ in which a large number of tissue-enriched genes are present. However, a large portion of transcripts related to each stage or cell type in the testis still remains unknown. In this study, databases combined with confirmatory measurements were used to investigate testis-enriched genes, localization in the testis, developmental regulation, gene expression profiles of testicular disease, and signaling pathways. Our comparative analysis of GEO DataSets showed that 24 genes are predominantly expressed in testis. Cellular locations of 15 testis-enriched proteins in human testis have been identified and most of them were located in spermatocytes and round spermatids. Real-time PCR revealed that expressions of these 15 genes are significantly increased during testis development. Also, an analysis of GEO DataSets indicated that expressions of these 15 genes were significantly decreased in teratozoospermic patients and polyubiquitin knockout mice, suggesting their involvement in normal testis development. Pathway analysis revealed that most of those 15 genes are implicated in various sperm-related cell processes and disease conditions. This approach provides effective strategies for discovering novel testis-enriched genes and their expression patterns, paving the way for future characterization of their functions regarding infertility and providing new biomarkers for specific stages of spematogenesis.

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Section: Methodsmentioning

confidence: 99%

Comparative expression profiling of testis-enriched genes regulated during the development of spermatogonial cells

et al. 2017

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“…The latter is involved in tissue differentiation 32 and was upregulated in response to exercise only in the hypoxic group. Dephosphorylation of YAP at Ser127is known to promote its nuclear translocation and its activation.…”

Section: Role Of the Hippo Pathwaymentioning

confidence: 98%

“…24,25 On the other hand, acute hypoxia promotes myogenic differentiation and induces nuclear factor kappa B (NF-κB)/IL-6/STAT3 and Hippo pathway activation, both known to activate the myogenic program. [29][30][31][32] The Hippo pathway fosters myogenesis through its two effectors, yes associated protein (YAP) and tafazzin (TAZ) transcription factors. 29 In turn, STAT3 regulates the expression of proteins involved in skeletal muscle and other tissue differentiation, such as cyclin D1,Myf5, myogenin, and peripheral myelin protein 22 (pmp22).…”

Section: Introductionmentioning

confidence: 99%

“…Mechanistically, IL‐6 is responsible for STAT3 translocation in the nucleus . In turn, STAT3 regulates the expression of proteins involved in skeletal muscle and other tissue differentiation, such as cyclin D1,Myf5, myogenin, and peripheral myelin protein 22 (pmp22) . The Hippo pathway fosters myogenesis through its two effectors, yes associated protein (YAP) and tafazzin (TAZ) transcription factors .…”

Section: Introductionmentioning

confidence: 99%

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Acute environmental hypoxia potentiates satellite cell‐dependent myogenesis in response to resistance exercise through the inflammation pathway in human

et al. 2019

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Abbreviations: ADAMTS5, ADAM metallopeptidase with thrombospondin type 1 motif 5; BHLHE40, basic helix-loop-helix family member E40; CTGF, connective tissue growth factor; Cyr61, cysteine-rich angiogenic inducer 61; FiO 2 , fraction of inspired oxygen; GM-CSF, granulocyte macrophage colony stimulating factor; Gulp1, GULP PTB domain containing engulfment adaptor 1; HIF-1, hypoxia-inducible factor-1; IFNγ, interferon gamma; IGF, insulin-like growth factor; Il, interleukin; IKzf2, IKAROS family zinc finger 2; MRF, myogenic regulatory factors; Myf5, myogenic factor 5; MyoD, myogenic differentiation; NF-κB, nuclear factor kappa B; Pax7, paired box 7; Pmp22, peripheral myelin protein 22; STAT3, signal transducer and activator of transcription 3; TAZ, Taffazin; TNFα, tumor necrosis factor alpha; YAP, yes associated protein. AbstractAcute environmental hypoxia may potentiate muscle hypertrophy in response to resistance training but the mechanisms are still unknown. To this end, twenty subjects performed a 1-leg knee extension session (8 sets of 8 repetitions at 80% 1 repetition maximum, 2-min rest between sets) in normoxic or normobaric hypoxic conditions (FiO2 14%). Muscle biopsies were taken 15 min and 4 hours after exercise in the vastus lateralis of the exercised and the non-exercised legs. Blood samples were taken immediately, 2h and 4h after exercise. In vivo, hypoxic exercise fostered acute inflammation mediated by the TNFα/NF-κB/IL-6/STAT3 (+333%, +194%, + 163% and +50% respectively) pathway, which has been shown to contribute to satellite cells myogenesis. Inflammation activation was followed by skeletal muscle invasion by CD68 (+63%) and CD197 (+152%) positive immune cells, both known to regulate muscle regeneration. The role of hypoxia-induced activation of inflammation in myogenesis was confirmed in vitro. Acute hypoxia promoted myogenesis through increased Myf5 (+300%), MyoD (+88%), myogenin (+1816%) and MRF4 (+489%) mRNA levels in primary myotubes and this response was blunted by siRNA targeting STAT3. In conclusion, our results suggest that hypoxia could improve muscle hypertrophic response following resistance exercise through IL-6/STAT3-dependent myogenesis and immune cells-dependent muscle regeneration. K E Y W O R D Sexercise, hypoxia, inflammation, muscle, myogenesis 1886 | BRITTO eT al.

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“…Only key points of these complex events are briefly summarized here. Increased expressions in cyclin-related cell cycle inhibitors (Zhang et al, 2014) but decreased expression in DLK1/Pref1 (Gondret et al, 2013), a factor expressed in preadipocytes and known to inhibit adipogenesis, and in IGF2 (Gardan et al, 2008), a fetal mitogen highly expressed during the proliferative phase that prevents leptin induction, have been enlightened during early development of adipose tissues in pigs. Transient increased abundances of cyclin-related cell cycle partners or other proteins have been also observed in bovine fetal adipose tissue.…”

Section: From Multipotent Stem Cells To Adipocytesmentioning

confidence: 99%

Invited review: Pre- and postnatal adipose tissue development in farm animals: from stem cells to adipocyte physiology

Louveau

Perruchot

Bonnet

et al. 2016

Animal

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Both white and brown adipose tissues are recognized to be differently involved in energy metabolism and are also able to secrete a variety of factors called adipokines that are involved in a wide range of physiological and metabolic functions. Brown adipose tissue is predominant around birth, except in pigs. Irrespective of species, white adipose tissue has a large capacity to expand postnatally and is able to adapt to a variety of factors. The aim of this review is to update the cellular and molecular mechanisms associated with pre-and postnatal adipose tissue development with a special focus on pigs and ruminants. In contrast to other tissues, the embryonic origin of adipose cells remains the subject of debate. Adipose cells arise from the recruitment of specific multipotent stem cells/progenitors named adipose tissue-derived stromal cells. Recent studies have highlighted the existence of a variety of those cells being able to differentiate into white, brown or brown-like/beige adipocytes. After commitment to the adipocyte lineage, progenitors undergo large changes in the expression of many genes involved in cell cycle arrest, lipid accumulation and secretory functions. Early nutrition can affect these processes during fetal and perinatal periods and can also influence or pre-determinate later growth of adipose tissue. How these changes may be related to adipose tissue functional maturity around birth and can influence newborn survival is discussed. Altogether, a better knowledge of fetal and postnatal adipose tissue development is important for various aspects of animal production, including neonatal survival, postnatal growth efficiency and health.

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Differential expression of cyclin G2, cyclin-dependent kinase inhibitor 2C and peripheral myelin protein 22 genes during adipogenesis

Cited by 11 publications

References 36 publications

Comparative expression profiling of testis-enriched genes regulated during the development of spermatogonial cells

Comparative expression profiling of testis-enriched genes regulated during the development of spermatogonial cells

Acute environmental hypoxia potentiates satellite cell‐dependent myogenesis in response to resistance exercise through the inflammation pathway in human

Invited review: Pre- and postnatal adipose tissue development in farm animals: from stem cells to adipocyte physiology

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