2020
DOI: 10.3389/fimmu.2020.00736
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Differential Expression of IgM and IgD Discriminates Two Subpopulations of Human Circulating IgM+IgD+CD27+ B Cells That Differ Phenotypically, Functionally, and Genetically

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Cited by 38 publications
(38 citation statements)
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“…However, prior to this, it will be beneficial to utilize exploratory approaches, such as single-cell RNAseq, to characterize these MZB-like cells residing within non-splenic tissue compartments of humans. Ongoing studies within the field would allow for direct comparison and quantification of transcriptomic similarities of these RM-residing B cells to traditional splenic MZB, as well as circulating MZB and other B cell subsets 34 . This will provide critical foundational information as to the natural function of these cells within the RM, as well as providing insight into how these cells could potentially participate in propagating HIV replication.…”
Section: Discussionmentioning
confidence: 99%
“…However, prior to this, it will be beneficial to utilize exploratory approaches, such as single-cell RNAseq, to characterize these MZB-like cells residing within non-splenic tissue compartments of humans. Ongoing studies within the field would allow for direct comparison and quantification of transcriptomic similarities of these RM-residing B cells to traditional splenic MZB, as well as circulating MZB and other B cell subsets 34 . This will provide critical foundational information as to the natural function of these cells within the RM, as well as providing insight into how these cells could potentially participate in propagating HIV replication.…”
Section: Discussionmentioning
confidence: 99%
“…The relevance of reduced TNF production by MZ‐like B cells after phototherapy requires further investigation. MZ‐like B cells represent a population of B cells that respond primarily to microbial signatures via TLRs and can undergo immunoglobulin class switching when activated with cytokines and TLR ligands 26 . In particular, MZ‐like B cells may be activated by neutrophils and undergo class switching in response to interferon‐γ 27 .…”
Section: Discussionmentioning
confidence: 99%
“…Plasmablasts (PB) and antibody-secreting cell (ASC)-like cells were excluded from analyses, as shown in Figures 1 and 2 , respectively. MZ-like B cells (CD27 + IgD + IgM + ) were divided into IgM hi and IgM lo MZ-like B cells as recently described ( 7 ). CD32b expression on all B cell subsets was examined using MFI.…”
Section: Methodsmentioning
confidence: 99%
“…MBC are often defined as CD27 + B cells, but these are in fact a heterogeneous population that include marginal zone (MZ)-like B cells (IgM + IgD + ), IgM-only MBC (IgM + IgD − ), and class switched MBC (IgD − /IgG +/− /IgA +/− /IgE +/− ). Each may exhibit diverse functional activities, in part due to differential expression of molecules such as CD21 and T bet ( 7 9 ), independent of their B cell receptor (BCR) isotype. Moreover, CD27 − B cells can also be antigen experienced, including IgD − CD27 − cells, the so-called double negative (DN) B cells, which may be IgM + or IgM - ( 10 ).…”
Section: Introductionmentioning
confidence: 99%