Differential expression of microRNA expression in tamoxifen-sensitive MCF-7 versus tamoxifen-resistant LY2 human breast cancer cells

Manavalan, Tissa T.; Teng, Yuee; Appana, Savitri; Datta, Susmita; Kalbfleisch, Theodore S.; Li, Yong; Klinge, Carolyn M.

doi:10.1016/j.canlet.2011.08.018

Cited by 68 publications

(69 citation statements)

References 77 publications

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“…2). In a microarray-based study on tamoxifen-sensitive MCF-7 and tamoxifen-resistant LY2 breast cancer cell lines, several novel miRNAs including miR-200c were found to be differentially expressed between sensitive and resistant cells [65]. In a later study by the same group, it has been shown that ectopic expression of miR-200c in endocrine-resistant LY2 cells has significant effect on enhanced sensitivity to fulvestrant, but not to tamoxifen [66].…”

Section: Mir-200c and Targeted Therapy Resistancementioning

confidence: 92%

miR-200c: a versatile watchdog in cancer progression, EMT, and drug resistance

et al. 2016

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MicroRNAs (miRNAs) are 20-22-nucleotide small endogenous non-coding RNAs which regulate gene expression at post-transcriptional level. In the last two decades, identification of almost 2600 miRNAs in human and their potential to be modulated opened a new avenue to target almost all hallmarks of cancer. miRNAs have been classified as tumor suppressors or oncogenes depending on the phenotype they induce, the targets they modulate, and the tissue where they function. miR-200c, an illustrious tumor suppressor, is one of the highly studied miRNAs in terms of development, stemness, proliferation, epithelial-mesenchymal transition (EMT), therapy resistance, and metastasis. In this review, we first focus on the regulation of miR-200c expression and its role in regulating EMT in a ZEB1/E-cadherin axis-dependent and ZEB1/E-cadherin axis-independent manner. We then describe the role of miR-200c in therapy resistance in terms of multidrug resistance, chemoresistance, targeted therapy resistance, and radiotherapy resistance in various cancer types. We highlight the importance of miR-200c at the intersection of EMT and chemoresistance. Furthermore, we show how miR-200c coordinates several important signaling cascades such as TGF-β signaling, PI3K/Akt signaling, Notch signaling, VEGF signaling, and NF-κB signaling. Finally, we discuss miR-200c as a potential prognostic/diagnostic biomarker in several diseases, but mainly focusing on cancer and its potential application in future therapeutics.

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Section: Mir-200c and Targeted Therapy Resistancementioning

confidence: 92%

miR-200c: a versatile watchdog in cancer progression, EMT, and drug resistance

et al. 2016

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“…Since miRNAs were first discovered, they have been identified as significant mediators in cellular physiology and pathology. Recently, studies have demonstrated that aberrant miRNA expression is strongly linked with tumor-related processes in humans (Fassan et al, 2011;Li et al, 2011;Manavalan et al, 2011;Matsuyama et al, 2011). Moreover, miRNAs appear to be potent regulators of gene expression in endometriosis and its associated reproductive disorders, raising the prospect of using miRNAs as biomarkers and therapeutic tools in endometriosis (Teague et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Microarray analysis of microRNA deregulation and angiogenesis-related proteins in endometriosis

Teng

et al. 2016

Genet. Mol. Res.

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ABSTRACT. We examined the aberrant microRNA (miRNA) expression profile responsible for the changes in angiogenesis observed in endometriotic lesions. This study revealed characteristic miRNA expression profiles associated with endometriosis in endometrial tissue and endometriotic lesions from the same patient, and their correlation with the most important angiogenic and fibrinolytic factors. miRNA expression was quantified using a microRNA array and reversetranscription microRNA polymerase chain reaction. Levels of vascular endothelial growth factor A (VEGFA), epidermal growth factor receptor 2 (EGFR2), phosphatase and tensin homolog (PTEN), and C-X-C chemokine receptor type 4 (CXCR4) were quantified using enzyme-linked immunosorbent assay. The endometrial tissue showed significantly lower levels of miR-200b, miR-15a-5p, miR-19b-1-5p, miR-146a-5p, and miR-200c, and higher levels of miR-16-5p, miR106b-5p, and miR-145-5p. VEGFA was significantly upregulated, whereas EGFR2, PTEN, and CXCR4 were markedly downregulated, in the endometriotic tissues compared to that in the normal endometrial tissues. In conclusion, differences in the miRNA levels could modulate the expression of VEGFA, EGFR2, PTEN, and CXCR4, and may play an important role in the pathogenesis of endometriosis. The higher angiogenic and proteolytic activities observed in the eutopic endometrium might facilitate the implantation of endometrial cells at ectopic sites.

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“…In addition to ERa, there is a plasma membrane-bound estrogen receptor that is a G-coupled protein receptor (GPR30IGPER) [11,12]. Filardo et al have shown that E2 can activate the MAPK signaling cascade via binding to GPR30 leading to transcription of cell proliferative genes [13] .…”

Section: Gpr30/ Gpermentioning

confidence: 99%

Dysregulation of microRNA expression in acquired endocrine-resistant breast cancer.

Manavalan¹

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Differential expression of microRNA expression in tamoxifen-sensitive MCF-7 versus tamoxifen-resistant LY2 human breast cancer cells

Cited by 68 publications

References 77 publications

miR-200c: a versatile watchdog in cancer progression, EMT, and drug resistance

miR-200c: a versatile watchdog in cancer progression, EMT, and drug resistance

Microarray analysis of microRNA deregulation and angiogenesis-related proteins in endometriosis

Dysregulation of microRNA expression in acquired endocrine-resistant breast cancer.

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