Differential gene expression of leaflet tissue in chronic ovine functional tricuspid regurgitation
Boguslaw Gaweda,
Austin Goodyke,
Jeremy Prokop
et al.
Abstract:OBJECTIVES
Severe functional tricuspid regurgitation (FTR) is associated with subvalvular remodelling, but leaflet tissue alterations may also contribute. We set out to investigate molecular mechanisms driving leaflet remodelling in chronic ovine FTR.
METHODS
Thirteen adult sheep (55 ± 4kg) underwent left thoracotomy, epicardial echocardiography, and pulmonary artery banding (PAB) to induce right heart failure and FTR. After … Show more
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