Differential growth factor retention by platelet-rich plasma composites

Tsay, Rick C.; Vo, Jennifer; Burke, Andrea; Eisig, Sidney B.; Lu, Helen H.; Landesberg, Regina

doi:10.1016/j.joms.2004.09.012

Cited by 144 publications

(33 citation statements)

References 26 publications

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“…Because calcium chloride is adopted to activate the coagulation cascade, the use of potentially toxic materials, such as bovine thrombin, is avoided [602]. In addition, the calcium results in reduced burst protein release compared with thrombin, leading to a more sustained delivery of growth factors [603]. Furthermore, leukocytes can be removed from PRGF to eliminate the pro-inflammatory impacts of the proteases contained in white blood cells, such as acid hydrolases and metalloproteases, which may provoke tissue-destroying effects [604].…”

Section: Formulations Enriched With Endogenous Growth Factorsmentioning

confidence: 99%

Advancing biomaterials of human origin for tissue engineering

Chen

Liu

2016

Progress in Polymer Science

963

513

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Biomaterials have played an increasingly prominent role in the success of biomedical devices and in the development of tissue engineering, which seeks to unlock the regenerative potential innate to human tissues/organs in a state of deterioration and to restore or reestablish normal bodily function. Advances in our understanding of regenerative biomaterials and their roles in new tissue formation can potentially open a new frontier in the fast-growing field of regenerative medicine. Taking inspiration from the role and multi-component construction of native extracellular matrices (ECMs) for cell accommodation, the synthetic biomaterials produced today routinely incorporate biologically active components to define an artificial in vivo milieu with complex and dynamic interactions that foster and regulate stem cells, similar to the events occurring in a natural cellular microenvironment. The range and degree of biomaterial sophistication have also dramatically increased as more knowledge has accumulated through materials science, matrix biology and tissue engineering. However, achieving clinical translation and commercial success requires regenerative biomaterials to be not only efficacious and safe but also cost-effective and convenient for use and production. Utilizing biomaterials of human origin as building blocks for therapeutic purposes has provided a facilitated approach that closely mimics the critical aspects of natural tissue with regard to its physical and chemical properties for the orchestration of wound healing and tissue regeneration. In addition to directly using tissue transfers and transplants for repair, new applications of human-derived biomaterials are now focusing on the use of naturally occurring biomacromolecules, decellularized ECM scaffolds and autologous preparations rich in growth factors/non-expanded stem cells to either target acceleration/magnification of the body's own repair capacity or use nature's paradigms to create new tissues for restoration. In particular, there is increasing interest in separating ECMs into simplified functional domains and/or biopolymeric assemblies so that these components/constituents can be discretely exploited and manipulated for the production of bioscaffolds and new biomimetic biomaterials. Here, following an overview of tissue auto-/allo-transplantation, we discuss the recent trends and advances as well as the challenges and future directions in the evolution and application of human-derived biomaterials for reconstructive surgery and tissue engineering. In particular, we focus on an exploration of the structural, mechanical, biochemical and biological information present in native human tissue for bioengineering applications and to provide inspiration for the design of future biomaterials.

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Section: Formulations Enriched With Endogenous Growth Factorsmentioning

confidence: 99%

Advancing biomaterials of human origin for tissue engineering

Chen

Liu

2016

Progress in Polymer Science

963

513

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“…57 It is believed that PRP contains growth factors and might therefore have biological properties that could enhance the regeneration of certain tissues. 58–61 It was also recently implied to have antimicrobial properties which also contribute to tissue repair and regeneration. 62 It has been demonstrated that the administration of PRP in combination with bone marrow cells during the consolidation phase of distraction osteogenesis enhances the bone healing process.…”

Section: Platelet-rich Plasmamentioning

confidence: 99%

The Molecular and Cellular Events That Take Place during Craniofacial Distraction Osteogenesis

Rachmiel

Leiser

2014

Plastic and Reconstructive Surgery Global Open

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Summary:Gradual bone lengthening using distraction osteogenesis principles is the gold standard for the treatment of hypoplastic facial bones. However, the long treatment time is a major disadvantage of the lengthening procedures. The aim of this study is to review the current literature and summarize the cellular and molecular events occurring during membranous craniofacial distraction osteogenesis. Mechanical stimulation by distraction induces biological responses of skeletal regeneration that is accomplished by a cascade of biological processes that may include differentiation of pluripotential tissue, angiogenesis, osteogenesis, mineralization, and remodeling. There are complex interactions between bone-forming osteoblasts and other cells present within the bone microenvironment, particularly vascular endothelial cells that may be pivotal members of a complex interactive communication network in bone. Studies have implicated number of cytokines that are intimately involved in the regulation of bone synthesis and turnover. The gene regulation of numerous cytokines (transforming growth factor-β, bone morphogenetic proteins, insulin-like growth factor-1, and fibroblast growth factor-2) and extracellular matrix proteins (osteonectin, osteopontin) during distraction osteogenesis has been best characterized and discussed. Understanding the biomolecular mechanisms that mediate membranous distraction osteogenesis may guide the development of targeted strategies designed to improve distraction osteogenesis and accelerate bone regeneration that may lead to shorten the treatment duration.

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“…PRP contains not only a number of GFs, including platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), transforming growth factor (TGF)-β, insulin-like growth factor (IGF), and fibroblast growth factor (FGF)-2, but also cytokines and inflammatory mediators (Rozman and Bolta, 2007). Unfortunately, the clinical evidence for PRP as a therapeutic agent is insufficient (Froum et al, 2002;Raghoebar et al, 2005) due to obstacles such as rapid washout (Tsay et al, 2005) and inactivation (Bir et al, 2009) of the critical proteins in PRP. However, there have been a few studies on the sustained delivery of GFs contained in PRP whose aims were to prevent initial washout and control the release of important proteins in PRP to the concerned area (Hokugo et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Enhanced skin wound healing by a sustained release of growth factors contained in platelet-rich plasma

et al. 2011

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Platelet-rich plasma (PRP) contains growth factors that promote tissue regeneration. Previously, we showed that heparin-conjugated fibrin (HCF) exerts the sustained release of growth factors with affinity for heparin. Here, we hypothesize that treatment of skin wound with a mixture of PRP and HCF exerts sustained release of several growth factors contained in PRP and promotes skin wound healing. The release of fibroblast growth factor 2, platelet-derived growth factor-BB, and vascular endothelial growth factor contained in PRP from HCF was sustained for a longer period than those from PRP, calcium-activated PRP (C-PRP), or a mixture of fibrin and PRP (F-PRP). Treatment of full-thickness skin wounds in mice with HCF-PRP resulted in much faster wound closure as well as dermal and epidermal regeneration at day 12 compared to treatment with either C-PRP or F-PRP. Enhanced skin regeneration observed in HCF-PRP group may have been at least partially due to enhanced angiogenesis in the wound beds. Therefore, this method could be useful for skin wound treatment.

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Differential growth factor retention by platelet-rich plasma composites

Cited by 144 publications

References 26 publications

Advancing biomaterials of human origin for tissue engineering

Advancing biomaterials of human origin for tissue engineering

The Molecular and Cellular Events That Take Place during Craniofacial Distraction Osteogenesis

Enhanced skin wound healing by a sustained release of growth factors contained in platelet-rich plasma

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