Differential growth factor retention by platelet-rich plasma composites

Tsay, Rick C.; Vo, Jennifer; Burke, Andrea; Eisig, Sidney B.; Lu, Helen H.; Landesberg, Regina

doi:10.1016/j.joms.2004.05.182

Cited by 126 publications

(97 citation statements)

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“…The platelet count of PRP in our study was 4-5 times the baseline value as done by Marx et al [1,2,5,22].…”

Section: Discussionsupporting

confidence: 67%

“…In our study PRP was prepared from 10 ml of patient's blood and centrifuged twice in a clinical tabletop centrifugation machine as advocated by, Rick C. Tsay et al [1], Aron Ganshor [11], Regina Landesberg et al [21].…”

Section: Discussionmentioning

confidence: 99%

“…The healing of fracture or wound is accomplished by the interaction of osteoblasts and extracellular matrix under the influence of various growth factors of which some are secreted by platelets [1]. These factors can activate the proliferation and differentiation of the local osteoprogenitor cells into bone forming cells leading to the formation of new bone matrix and mineralization [2].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Efficacy of Platelet Rich Plasma and Hydroxyapatite Crystals in Bone Regeneration After Surgical Removal of Mandibular Third Molars

Kaur¹,

Maria

2012

J. Maxillofac. Oral Surg.

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Purpose This study evaluates the efficacy of platelet rich plasma (PRP) & porous hydroxyapatite crystals in bone regeneration after surgical removal of mandibular third molar with the help of radiographs and its comparison with control side. Materials and Methods A total of 40 patients; both male and female aged between 18 and 35 years, who had impacted mandibular third molars were randomly selected for this study. Twenty patients were taken for control group and 20 patients for study group. The extraction socket of the study group was packed with PRP and hydroxyapatite granules and that of control group was sutured without PRP and hydroxyapatite. The bone density of both extraction sockets were evaluated radiographically using gray level histogram and compared periodically on immediate postoperative day, 1st and 3rd month postoperatively and postoperative sequelae of both the control group and study group in terms of oedema & pain or any other adverse reactions were also assessed. Results Data suggested evidence of early bone formation and maturation radiographically in study group as compared to control group. The percentage of facial swelling was numerically greater on the control side as compared to the study side, Pain was also assessed with VAS and it was found that the severity of pain was equal in both study and control groups and the results were not significant. Conclusion This study clearly indicated a definitive improvement in the wound healing, increase in bone density, which signifies and highlights the use of PRP and hydroxyapatite granules, certainly as a valid method in inducing and accelerating bone regeneration.

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“…The platelet count of PRP in our study was 4-5 times the baseline value as done by Marx et al [1,2,5,22].…”

Section: Discussionsupporting

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy of Platelet Rich Plasma and Hydroxyapatite Crystals in Bone Regeneration After Surgical Removal of Mandibular Third Molars

Kaur¹,

Maria

2012

J. Maxillofac. Oral Surg.

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“…Os fatores de crescimento são degranulados pelas plaquetas presentes no PRP logo após sua coagulação e atuam na fase inicial do processo de reparo (Marx, 2001(Marx, , 2004Tsay, 2005).…”

Section: Nú M E Ro D E O S T E O B La S T O S /á Re a T O T A L D Ifeunclassified

Efeito da utilização de plasma rico em plaquetas na osteointegração dos enxertos ósseos homólogos criopreservados: estudo histomorfométrico em coelhos

Augusto¹,

Santos²

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“…that continuously releases cytokines like transforming growth factor (TGF ß1), Platelet derived growth factor (PDGF), and Vascular -endothelial growth factor (VEGF), the peak level of their release coincides with the cell growth around 14th day. Whereas 81.4 % of TGF ß1 released on the first day from PRP and thereafter it decreases at 3,7 and 14 days [19]. The PRF accumulates platelets and release cytokines that enhances proliferation of multiple cell types, stimulates cell differentiation and helps angiogenesis and combines healing and immunity promoters [20].…”

Section: International Journal Of Dental Sciences and Researchmentioning

confidence: 99%

Tissue Engineering: An Analogous Platelet Rich Fibrin for Coronal Pulpotomy in Revival of Pulp Tissue Vitality in Adult Molar with Pulpitis, a Case Report

Aleid¹

2018

IJDSR

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Aim: management of a clinical case with irreversible pulpitis for young adult molar with closed apices using analogous blood derivative PRF and evaluating the clinical and radiographic success for coronal pulpotomy. Summary: A 18 years old male patient reported to the screening clinic, was referred to endodontic clinic with acute pulpitis diagnosed in left first molar tooth. Deep occlusal caries involving pulp, with history of spontaneous lingering pain associated with sign and symptoms of pulpitis. Standard clinical care protocol was strictly implemented, rubber dam isolation was followed by coronal pulpotomy. Blood drawn from cuboidal vein. Platelet rich fibrin membrane placed over the remaining pulp and restored with MTA and finally with Glass ionomer cement. Follow-up results clinically and radio-graphically were encouraging and successful at day 1 to 24 months. No postoperative pain, the treated tooth responded to pulp sensibility test and radiographs revealed periapical healing. However, for standardization of the clinical procedure well designed research study is further needed.

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Differential growth factor retention by platelet-rich plasma composites

Cited by 126 publications

References 0 publications

Efficacy of Platelet Rich Plasma and Hydroxyapatite Crystals in Bone Regeneration After Surgical Removal of Mandibular Third Molars

Efficacy of Platelet Rich Plasma and Hydroxyapatite Crystals in Bone Regeneration After Surgical Removal of Mandibular Third Molars

Efeito da utilização de plasma rico em plaquetas na osteointegração dos enxertos ósseos homólogos criopreservados: estudo histomorfométrico em coelhos

Tissue Engineering: An Analogous Platelet Rich Fibrin for Coronal Pulpotomy in Revival of Pulp Tissue Vitality in Adult Molar with Pulpitis, a Case Report

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