Differential inhibition of reverse transcriptase and cellular DNA polymerase-α activities by lignans isolated from Chinese herbs, Phyllanthus myrtifolius Moon, and tannins from Lonicera japonica Thunb and Castanopsis hystrix

Chang, Chia‐Lun; Lin, Mei Tsu; Lee, Shoei‐Sheng; Liu, Karin C. S. Chen; Hsu, Feng Lin; Lin, Jin‐Yuarn

doi:10.1016/0166-3542(95)00020-m

Cited by 119 publications

(59 citation statements)

References 13 publications

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“…For further evidence MS 3 experiments of m/z 543 + 367 for isomers 16 and 17 were performed and these probed the MS 3 spectra similarity to methyl 3-caffeoylquinate and methyl 4-caffeoylquinate. Based on the above arguments, relative hydrophobicity and fragmentation analogy with the methyl dicaffeoylquinates, the second and third eluting isomers were assigned as methyl 3-caffeoyl-5-feruloylquinate (16) and methyl 4-caffeoyl-5-feruloylquinate (17).…”

Section: Characterization Of Methyl Caffeoyl-feruloylquinates (M R 543)mentioning

confidence: 99%

How to identify and discriminate between the methyl quinates of chlorogenic acids by liquid chromatography–tandem mass spectrometry

Jaiswal

Kuhnert

2011

J. Mass Spectrom.

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The methyl esters of chlorogenic acids, methyl quinates, are widely distributed in plant materials and frequently appear as extraction artifacts in plant samples. This is the first time when liquid chromatography-tandem mass spectrometry methods have been used for the identification and characterization of the methyl quinates. For this purpose, methyl quinates of mono caffeoylquinic acids and mono feruloylquinic acids were synthesized as authentic standards. The methyl quinates of mono and diacyl chlorogenic acids have shown characteristic fragmentation pattern in their tandem mass spectra. MS(n + 1) spectra of the methyl quinates of diacyl chlorogenic acids were identical to MS(n) spectra of mono acyl derivatives. These quinates do not produce any methyl quinate peak at m/z 205 if compared with quinic acid peak at m/z 191 in negative ion mode. In the MS(n) spectra of these quinates, cinnamic acid part or cinnamoyl part was detected as a base peak in negative ion mode. The retention time, order of elution and fragmentation pattern were completely different if compared with LC-MS(n) methods developed for chlorogenic acids. These LC-MS(n) methods have been applied for the identification and regioisomeric characterization of the methyl quinates of chlorogenic acids in maté tea and woodruff (Galium odoratum). Two methyl caffeoylquinates (2 and 4) were identified as methyl 3-caffeoylquinate and methyl 5-caffeoylquinate.

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Section: Characterization Of Methyl Caffeoyl-feruloylquinates (M R 543)mentioning

confidence: 99%

How to identify and discriminate between the methyl quinates of chlorogenic acids by liquid chromatography–tandem mass spectrometry

Jaiswal

Kuhnert

2011

J. Mass Spectrom.

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“…L. japonica is traditionally used as a medicinal plant (Peng, Mei, Jiang, Zhou, & Sun, 2000). Pharmacological studies and clinical practice have demonstrated that L. japonica possesses many biological functions, including hepatoprotective, cytoprotective, antimicrobial, antioxidative, antiviral and anti-inflammatory (Chang et al, 1995). The constituents of this plant have been previously investigated and shown to contain iridoid glucosides (Kakuda, Imai, Yaoita, Machida, & Kikuchi, 2000) and polyphenolic compounds (Peng et al, 2000).…”

Section: Introductionmentioning

confidence: 98%

In vitro control of food-borne and food spoilage bacteria by essential oil and ethanol extracts of Lonicera japonica Thunb.

Rahman¹,

Kang²

2009

Food Chemistry

115

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“…These compounds were reported to be responsible for the pharmacological actions of these plants [Blumberg, 1998]. Many studies suggest that most species of the genus Phyllanthus have a beneficial effect against HBV, possibly through inhibition of polymerase activity, mRNA transcription, and replication [Venkateswaran et al, 1987;Chang et al, 1995;Lee et al, 1996;Ott et al, 1997].…”

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confidence: 99%

Antiviral effect of Phyllanthus nanus ethanolic extract against hepatitis B virus (HBV) by expression microarray analysis

Lam

Leung

Law

et al. 2005

J of Cellular Biochemistry

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Ethanolic extract of Phyllanthus nanus (P. nanus) treatment exhibited potent antiviral activity against Hepatitis B virus (HBV). The effects of these extracts on HBV in the HBV genome integrated cell lines--Alexander cells and HepG2 2.2.15 cells were examined. Experimental results showed that the ethanolic extract of P. nanus produced suppressive effect on HBsAg secretion and HBsAg mRNA expression. The extract also inhibited HBV replication as measured by HBV DNA level in vitro. In addition, using a duck HBV (DHBV) primary culture model, the P. nanus ethanolic extract suppressed viral replication of DHBV in DHBV infected primary duck hepatocytes. The gene expression pattern in Alexander cells that had been treated with the ethanolic extract of P. nanus was also revealed by microarray techniques. The microarray results indicated that there was up-regulation of expression of several genes, including annexin A7 (Axn7). The subcellular localization of Axn7 and anti-HBV effect of Axn7 over-expression in Alexander cells were also investigated. Results showed that expression of Axn7-GFP fusion protein are localized around the secretory vesicles and could cause a decrease in HBsAg secretion in Alexander cells. Axn7 protein might play an important role in the medicinal effect of the active principle(s) of P. nanus.

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Differential inhibition of reverse transcriptase and cellular DNA polymerase-α activities by lignans isolated from Chinese herbs, Phyllanthus myrtifolius Moon, and tannins from Lonicera japonica Thunb and Castanopsis hystrix

Cited by 119 publications

References 13 publications

How to identify and discriminate between the methyl quinates of chlorogenic acids by liquid chromatography–tandem mass spectrometry

How to identify and discriminate between the methyl quinates of chlorogenic acids by liquid chromatography–tandem mass spectrometry

In vitro control of food-borne and food spoilage bacteria by essential oil and ethanol extracts of Lonicera japonica Thunb.

Antiviral effect of Phyllanthus nanus ethanolic extract against hepatitis B virus (HBV) by expression microarray analysis

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