Differential interactions of essential and toxic metal ions with biologically relevant phosphatidic acid and phosphatidylserine membranes

Global threat posed by metals and metalloids in the changing environment: a One Health approach to mechanisms of toxicity

“…Humans are increasingly exposed to metal pollutants including manganese (Mn), cobalt (Co), and nickel (Ni) that are toxic in high amounts in contrast to Pb and Cd toxicity at low micromolar concentrations. The effects of these metals on the signaling lipids phosphatidic acid, which also affects membrane curvature and gates ion channels, and phosphatidylserine, an apoptosis marker, were examined by Issler et al (2024). Metals increased the phase transition temperature, reduced membrane fluidity and increased liposome size.…”

“…In mammalians, speciation of MMs determines their transport modality in the blood (Doroudian et al 2023) and distribution within cells, tissues and organs (Thévenod and Lee 2024). At the cellular level, metals directly interact with numerous biological molecules, such as lipids (Issler et al 2024), eliciting toxicity and cell death (Pradhan et al 2024;Shao et al 2024). Furthermore, combinations of trace elements with MMs have consequences on the bioinorganic chemistry of MMs (Doroudian et al 2023), interaction with organic molecules (Issler et al 2024) and even markers of organ injury (Ortega-Romero et al…”

Potential Therapeutic Properties of Olea europaea Leaves from Selected Cultivars Based on Their Mineral and Organic Profiles

“…Manganese is implicated in several biological processes, with the literature describing manganese deficiencies as uncommon but holding a concern for the association of cancer susceptibility with low Mn-dependent superoxide dismutase activity. A vegetarian lifestyle prevents Mn deficiency though it might lead to iron deficiency [ 44 ], which in turn may lead to anemia, and copper build-up in the duodenal epithelium and liver [ 45 ]. Copper is predominantly found in the human brain, being absorbed in the intestine and excreted through bile [ 46 ]; moreover, it has been identified as a potential therapeutic target for obesity and nonalcoholic fatty liver disease (NAFLD), Alzheimer’s disease (AD), and Parkinson’s disease (PD), among others [ 39 ].…”

“…Manganese is implicated in several biological processes, with the literature describing manganese deficiencies as uncommon but holding a concern for the association of cancer susceptibility with low Mn-dependent superoxide dismutase activity. A vegetarian lifestyle prevents Mn deficiency though it might lead to iron deficiency [44], which in turn may lead to anemia, and copper build-up in the duodenal epithelium and liver [45].…”