Differential localization of mRNAs encoding dopamine D1 or D2 receptors in cholinergic neurons in the core and shell of the rat nucleus accumbens

Jongen-Rêlo, Ana L.; Docter, Gerrit J.; Jonker, Allert J.; Voorn, Pieter

doi:10.1016/0169-328x(94)00239-b

Cited by 26 publications

(19 citation statements)

References 28 publications

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“…D1 and D2 receptor mRNAs are expressed in cholinergic interneurons in the nucleus accumbens (MacLennan et al . 1994; Jongen‐Relo et al . 1995), and co‐stimulation of D1‐ and D2‐like receptors in the striatum leads to increased c‐fos mRNA expression in cholinergic interneurons (Svenningsson et al .…”

Section: Discussionmentioning

confidence: 99%

D1–D2 dopamine receptor interaction within the nucleus accumbens mediates long‐loop negative feedback to the ventral tegmental area (VTA)

Rahman

McBride

2001

Journal of Neurochemistry

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The objective of the present study was to examine the effects of perfusion of dopamine (DA) D1-and D2-like receptor agonists in the nucleus accumbens (ACB) on the long-loop negative feedback regulation of mesolimbic somatodendritic DA release in the ventral tegmental area (VTA) of Wistar rats employing ipsilateral dual probe in vivo microdialysis. Perfusion of the ACB for 60 min with the D1-like receptor agonist SKF 38393 (SKF, 1±100 mM) dose-dependently reduced the extracellular levels of DA in the ACB, whereas the extracellular levels of DA in the VTA were not changed. Similarly, application of the D2-like receptor agonist quinpirole (Quin, 1±100 mM) through the microdialysis probe in the ACB reduced the extracellular levels of DA in the ACB in a concentration-dependent manner, whereas extracellular levels of DA in the VTA were not altered. Co-application of SKF (100 mM) and Quin (100 mM) produced concomitant reductions in the extracellular levels of DA in the ACB and VTA. The reduction in extracellular levels of DA in the ACB and VTA produced by co-infusion of SKF and Quin was reversed in the presence of either 100 mM SCH 23390 (D1-like antagonist) or 100 mM sulpiride (D2-like antagonist). Overall, the results suggest that (a) activation of dopamine D1-or D2-like receptors can independently regulate local terminal DA release in the ACB, whereas stimulation of both subtypes is required for activation of the negative feedback pathway to the VTA.

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Section: Discussionmentioning

confidence: 99%

D1–D2 dopamine receptor interaction within the nucleus accumbens mediates long‐loop negative feedback to the ventral tegmental area (VTA)

Rahman

McBride

2001

Journal of Neurochemistry

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“…Despite this paucity of synaptic contacts, it is clear that ChIs activity is highly sensitive to dopamine receptor modulation, albeit to varying degrees between the dorsal and ventral striatum. In both striatal regions, D2 dopamine receptor mRNA is strongly expressed in ChIs, with the greatest densities found in the dorsolateral caudate–putamen complex of rodents . The majority of ChIs in the dorsal and ventral striatum also express moderate to high levels of D5 dopamine receptors .…”

Section: Synaptic Regulation Of Striatal Chismentioning

confidence: 99%

Cholinergic interneurons in the dorsal and ventral striatum: anatomical and functional considerations in normal and diseased conditions

Gonzales

Smith

2015

Annals of the New York Academy of Sciences

139

131

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Striatal cholinergic interneurons (ChIs) are central for the processing and reinforcement of reward-related behaviors that are negatively affected in states of altered dopamine transmission, such as in Parkinson’s disease or drug addiction. Nevertheless, the development of therapeutic interventions directed at ChIs has been hampered by our limited knowledge of the diverse anatomical and functional characteristics of these neurons in the dorsal and ventral striatum, combined with the lack of pharmacological tools to modulate specific cholinergic receptor subtypes. This review highlights some of the key morphological, synaptic, and functional differences between ChIs of different striatal regions and across species. It also provides an overview of our current knowledge of the cellular localization and function of cholinergic receptor subtypes. The future use of high-resolution anatomical and functional tools to study the synaptic microcircuitry of brain networks, along with the development of specific cholinergic receptor drugs, should help further elucidate the role of striatal ChIs and permit efficient targeting of cholinergic systems in various brain disorders, including Parkinson’s disease and addiction.

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“…It has also been reported that direct infusion of amphetamine into the rostral shell, caudal shell, or core differentially affects behavioral activity and extracellular dopamine and serotonin levels (Heidbreder and Feldon, 1998). Regulation of opioid peptides, substance P, dopamine D1 receptors (Voorn and Docter, 1992;Jongen-Relo et al, 1994b;Voorn et al, 1994), and acetylcholine release (Jongen-Relo et al, 1995) by dopamine and dopamine receptor agonists also differs between the rostral and caudal parts of the accumbens, with the rostral accumbens being more sensitive to dopamine depletion and administration. Although these functional differences between the rostral and caudal nucleus accumbens have been reported, why these functional differences exist is still not fully understood.…”

Section: Sexual Experience Effects On C-fos Expression Through the Romentioning

confidence: 99%

Sexual Behavior Induction of c-Fos in the Nucleus Accumbens and Amphetamine-Stimulated Locomotor Activity Are Sensitized by Previous Sexual Experience in Female Syrian Hamsters

Bradley¹,

Meisel

2001

J. Neurosci.

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Dopamine transmission in the nucleus accumbens can be activated by drugs, stress, or motivated behaviors, and repeated exposure to these stimuli can sensitize this dopamine response. The objectives of this study were to determine whether female sexual behavior activates nucleus accumbens neurons and whether past sexual experience cross-sensitizes neuronal responses in the nucleus accumbens to amphetamine. Using immunocytochemical labeling, c-Fos expression in different subregions (shell vs core at the rostral, middle, and caudal levels) of the nucleus accumbens was examined in female hamsters that had varying amounts of sexual experience. Female hamsters, given either 6 weeks of sexual experience or remaining sexually naive, were tested for sexual behavior by exposure to adult male hamsters. Previous sexual experience increased c-Fos labeling in the rostral and caudal levels but not in the middle levels of the nucleus accumbens. Testing for sexual behavior increased labeling in the core, but not the shell, of the nucleus accumbens. To validate that female sexual behavior can sensitize neurons in the mesolimbic dopamine pathway, the locomotor responses of sexually experienced and sexually naive females to an amphetamine injection were then compared. Amphetamine increased general locomotor activity in all females. However, sexually experienced animals responded sooner to amphetamine than did sexually naive animals. These data indicate that female sexual behavior can activate neurons in the nucleus accumbens and that sexual experience can cross-sensitize neuronal responses to amphetamine. In addition, these results provide additional evidence for functional differences between the shell and core of the nucleus accumbens and across its anteroposterior axis.Key words: female sexual behavior; nucleus accumbens; shell; core; c-Fos; sensitization; cross-sensitization; amphetamine Dopamine neurons originating in the midbrain ventral tegmental area and projecting to various forebrain nuclei, including the nucleus accumbens, are part of the mesolimbic dopamine system. It has been suggested that this dopamine system is important for the regulation of appetitive behaviors (Mitchell and Gratton, 1994;Salamone, 1994Salamone, , 1996Ikemoto and Panksepp, 1999), as well as self-administration of drugs of abuse (Pierre and Vezina, 1998;Koob, 1999;Lorrain et al., 1999;McKinzie et al., 1999;Peoples et al., 1999;Bradberry et al., 2000). Systemic administration of a variety of drugs of abuse (e.g., cocaine, amphetamine, and heroin) activates dopamine pathways (Pontieri et al., 1995;Nisell et al., 1997;Pierce and Kalivas, 1997a;Tanda et al., 1997;Tanda and Di Chiara, 1998;Barrot et al., 1999;Cadoni and Di Chiara, 1999), and repeated exposure to these pharmacological agents can sensitize these dopamine-responsive neurons (Robinson et al., 1988;Kalivas et al., 1992;Kalivas and Duffy, 1993;Pierce and Kalivas, 1995;Kuczenski et al., 1997;Nisell et al., 1997;Birrell and Balfour, 1998;Heidbreder and Feldon, 1998;Cadoni and Di Chiara, 1999;Ca...

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Differential localization of mRNAs encoding dopamine D1 or D2 receptors in cholinergic neurons in the core and shell of the rat nucleus accumbens

Cited by 26 publications

References 28 publications

D1–D2 dopamine receptor interaction within the nucleus accumbens mediates long‐loop negative feedback to the ventral tegmental area (VTA)

D1–D2 dopamine receptor interaction within the nucleus accumbens mediates long‐loop negative feedback to the ventral tegmental area (VTA)

Cholinergic interneurons in the dorsal and ventral striatum: anatomical and functional considerations in normal and diseased conditions

Sexual Behavior Induction of c-Fos in the Nucleus Accumbens and Amphetamine-Stimulated Locomotor Activity Are Sensitized by Previous Sexual Experience in Female Syrian Hamsters

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