Differential mobility spectrometry followed by tandem mass spectrometry with multiple ion monitoring for bioanalysis of eptifibatide in rat plasma

Ren, Tianming; Li, Runzhi; Meng, Xiangjun; Fawcett, J. Paul; Sun, Dawei; Gu, Jingkai

doi:10.1016/j.jpba.2018.01.019

Cited by 9 publications

(5 citation statements)

References 10 publications

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“…In Figure 4, the improvement in sensitivity obtained in the determination of eptifibatide in rat plasma with LC-DMS-multiple ion monitoring (LC-DMS-MIM) with respect to LC-MIM or LC-multiple reaction monitoring (LC-MRM) is shown. The results suggest that LC-DMS-MIM can be considered as a proper bioanalytical alternative for compounds with poor CID efficiency [108]. Kayleigh and coworkers reported also an increase in signalto-noise ratios by eliminating interferences for the determination of anabolic-androgenic steroid metabolites in urine using LC-FAIMS-MS.…”

Section: Field Asymmetric Waveform Ion Mobility Spectrometry (Faims) and Differential Mobility Spectrometry (Dms)mentioning

confidence: 95%

“…Among all the ion mobility techniques, DMS-MS is the most widely used in the bioanalytical field. DMS coupled with MS is mainly used as a filtering process both in combination with liquid chromatography (LC) [105][106][107][108][109] or as a stand-alone separation [110,111]. The filtering capacity of the technique provides clear benefits in terms of eliminating interferences and reducing background noise, which can entail an increase in sensitivity.…”

Section: Field Asymmetric Waveform Ion Mobility Spectrometry (Faims) and Differential Mobility Spectrometry (Dms)mentioning

confidence: 99%

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Ion Mobility–Mass Spectrometry for Bioanalysis

et al. 2021

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This paper aims to cover the main strategies based on ion mobility spectrometry (IMS) for the analysis of biological samples. The determination of endogenous and exogenous compounds in such samples is important for the understanding of the health status of individuals. For this reason, the development of new approaches that can be complementary to the ones already established (mainly based on liquid chromatography coupled to mass spectrometry) is welcomed. In this regard, ion mobility spectrometry has appeared in the analytical scenario as a powerful technique for the separation and characterization of compounds based on their mobility. IMS has been used in several areas taking advantage of its orthogonality with other analytical separation techniques, such as liquid chromatography, gas chromatography, capillary electrophoresis, or supercritical fluid chromatography. Bioanalysis is not one of the areas where IMS has been more extensively applied. However, over the last years, the interest in using this approach for the analysis of biological samples has clearly increased. This paper introduces the reader to the principles controlling the separation in IMS and reviews recent applications using this technique in the field of bioanalysis.

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Section: Field Asymmetric Waveform Ion Mobility Spectrometry (Faims) and Differential Mobility Spectrometry (Dms)mentioning

confidence: 95%

Section: Field Asymmetric Waveform Ion Mobility Spectrometry (Faims) and Differential Mobility Spectrometry (Dms)mentioning

confidence: 99%

Ion Mobility–Mass Spectrometry for Bioanalysis

et al. 2021

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“…The insB:9-23 concentration in the plasma of mice at different physiological and pathological settings were determined by a mass spectrometric method modified from previous reports (Ren et al, 2018;Su et al, 2017). The plasma was derived from WT mice (fed on NCD or HFD) or Akita mice at resting state or 30 minutes after intraperitoneal injection of 2 mg/g body weight glucose or control vehicle.…”

Section: Insb:9-23 Quantificationmentioning

confidence: 99%

Autonomous sensing of the insulin peptide by an olfactory G protein-coupled receptor modulates glucose metabolism

Cheng

Yang

et al. 2022

Cell Metabolism

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“…Improvements in the ion transmission system and detector lead to better quantitative ability. The Q-trap instruments have been used in many fields, such as clinical trials (Roosendaal et al, 2019), pharmacokinetic studies (Ren et al, 2018) and targeted lipidome analysis (Khan et al, 2020).…”

Section: Combination Of Quadrupole and Ion Trap (Q-trap)mentioning

confidence: 99%

Towards Higher Sensitivity of Mass Spectrometry: A Perspective From the Mass Analyzers

Li¹,

Chu²,

Tan³

et al. 2021

Front. Chem.

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Mass spectrometry (MS) is one of the most widely used analytical techniques in many fields. Recent developments in chemical and biological researches have drawn much attention to the measurement of substances with low abundances in samples. Continuous efforts have been made consequently to further improve the sensitivity of MS. Modifications on the mass analyzers of mass spectrometers offer a direct, universal and practical way to obtain higher sensitivity. This review provides a comprehensive overview of the latest developments in mass analyzers for the improvement of mass spectrometers’ sensitivity, including quadrupole, ion trap, time-of-flight (TOF) and Fourier transform ion cyclotron (FT-ICR), as well as different combinations of these mass analyzers. The advantages and limitations of different mass analyzers and their combinations are compared and discussed. This review provides guidance to the selection of suitable mass spectrometers in chemical and biological analytical applications. It is also beneficial to the development of novel mass spectrometers.

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Differential mobility spectrometry followed by tandem mass spectrometry with multiple ion monitoring for bioanalysis of eptifibatide in rat plasma

Cited by 9 publications

References 10 publications

Ion Mobility–Mass Spectrometry for Bioanalysis

Ion Mobility–Mass Spectrometry for Bioanalysis

Autonomous sensing of the insulin peptide by an olfactory G protein-coupled receptor modulates glucose metabolism

Towards Higher Sensitivity of Mass Spectrometry: A Perspective From the Mass Analyzers

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