Differential neural network of checking versus washing symptoms in obsessive-compulsive disorder

Imaging Studies of Anxiety Disorders

“…Three articles found hypoactivity in task-based fMRI (Milad et al, 2013;Nabeyama et al, 2008;Woolley et al, 2008), and one study found hypoactivity in resting state (Blair et al, 2013), consistent with three studies reporting hyperactivation in task-based fMRI (Murayama et al, 2013;Page et al, 2009;Sanematsu et al, 2010).…”

“…Seven studies found hypoactivation (Kang, Jang, Han, et al, 2013;Koch, Wagner, Schachtzabel, et al, 2012;Murayama, Nakao, Sanematsu, et al, 2013;Nabeyama, Nakagawa, Yoshiura, et al, 2008;Nakao, Nakagawa, Yoshiura, et al, 2005;Pena-Garijo et al, 2011;Yucel, Harrison, Wood, et al, 2007), consistent with hyperactivity in two studies of resting state (Blair et al, 2013;Cheng, Xu, Nie, et al, 2013), and 13 studies found hyperactivation in task-based fMRI (Adler et al, 2000;Breiter et al, 1996;Fitzgerald, Welsh, Gehring, et al, 2005;Fitzgerald et al, 2010;Huyser et al, 2011;Maltby et al, 2005;Remijnse et al, 2013;Schiepek, Tominschek, Karch, et al, 2009;Schlosser et al, 2010;Ursu, Stenger, Shear, Jones, & Carter, 2003;Viard et al, 2005). Seven studies found hypoactivation (Kang, Jang, Han, et al, 2013;Koch, Wagner, Schachtzabel, et al, 2012;Murayama, Nakao, Sanematsu, et al, 2013;Nabeyama, Nakagawa, Yoshiura, et al, 2008;Nakao, Nakagawa, Yoshiura, et al, 2005;Pena-Garijo et al, 2011;Yucel, Harrison, Wood, et al, 2007), consistent with hyperactivity in two studies of resting state (Blair et al, 2013;Cheng, Xu, Nie, et al, 2013), and 13 studies found hyperactivation in task-based fMRI (Adler et al, 2000;Breiter et al, 1996;Fitzgerald, Welsh, Gehring, et al, 2005;Fitzgerald et al, 2010;Huys...…”

“…The striatum is the main region of interest with 12 studies reporting hypoactivation (Blair et al, 2011;Freyer et al, 2011;Gilbert et al, 2009;Milad et al, 2013;Murayama et al, 2013;Nakao et al, 2005Nakao et al, , 2009Page et al, 2009;Pena-Garijo et al, 2011;Remijnse et al, 2006Remijnse et al, , 2009Van Den Heuvel et al, 2005a), and eight studies reported hyperactivation (Breiter et al, 1996;Han et al, 2011;Maltby et al, 2005;Mataix-Cols et al, 2004;Phillips et al, 2000;Remijnse et al, 2013;Schienle et al, 2005;Simon et al, 2010).…”

Neuropsychological differences between obsessive-compulsive washers and checkers: A systematic review and meta-analysis

“…In a recent fMRI study also applying a symptom provocation paradigm, Murayama et al (2013) reported that checking rituals were associated with subcortical brain regions such as the nucleus caudatus and anterior cingulate cortex, whereas washing rituals were associated with large cortical brain regions including the cerebellum.…”

Brain Structural Alterations in Obsessive-Compulsive Disorder Patients with Autogenous and Reactive Obsessions

“…Reports comparing patients with different symptom profiles have identified differences in their sociodemographical and clinical features, as well as neurobiological correlates. For instance, in symptom provocation studies, relatively distinctive patterns of brain activity have been associated with the presentation of stimuli representing discrete OCD symptom dimensions, such as aggression/checking and contamination/cleaning symptoms [6]–[8].…”