2019
DOI: 10.1186/s12958-019-0523-6
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Differential placental ceramide levels during gestational diabetes mellitus (GDM)

Abstract: BackgroundGestational diabetes mellitus (GDM) is associated with important factors that influence fetal development. Sphingolipids are known to be associated with the development of diabetes. Our objective was to examine ceramide, a key sphingolipid, hyperosmolarity, and apoptosis in placentas from GDM patients treated with insulin or diet.MethodsCeramide levels were assessed in placental tissues using immunohistochemistry. Immunoblot was performed to quantify serine palmitoyltransferase (SPT), the rate-limiti… Show more

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Cited by 16 publications
(12 citation statements)
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“…It is well established that placenta is a special organ with multiple functions, such as its involvement in digestive, excretory, respiratory and immune systems 23 . Besides, it also has shown critical effect on the fetal development and overall outcomes during pregnancy by regulating the nutrients exchange and waste products disposal 24,25 . Importantly, the increased placental IR has been indicated as one of the characteristic feature of GDM, 26 which makes placenta a focus for the investigation of GDM pathogenesis.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…It is well established that placenta is a special organ with multiple functions, such as its involvement in digestive, excretory, respiratory and immune systems 23 . Besides, it also has shown critical effect on the fetal development and overall outcomes during pregnancy by regulating the nutrients exchange and waste products disposal 24,25 . Importantly, the increased placental IR has been indicated as one of the characteristic feature of GDM, 26 which makes placenta a focus for the investigation of GDM pathogenesis.…”
Section: Discussionmentioning
confidence: 99%
“…Actually, some typical alterations, such as increased levels of placental lactogen and growth hormones during the pregnancy can effectively induce IR and make placenta a unique organ for insulin signalling. Placental trophoblasts are a group of cells distributing in the outer layer of placenta, and their fundamental functions have been documented to play an important part in the process of nutrient transport, which is a significant step for fetal development 24,27 . Previous studies have also revealed that the dysfunctional trophoblasts are involved with several pregnancy‐related disorders, including the GDM, 28,29 and the insulin resistance in trophoblast has been determined to be a research target against GDM 26 .…”
Section: Discussionmentioning
confidence: 99%
“…Mitochondria are also important to trophoblast function, with alterations in trophoblast mitochondrial function evident in conditions associated with offspring obesity, including preeclampsia and gestation diabetes [91,92]. The decrease in trophoblast mitochondrial respiration in gestational diabetes seems mediated by an increase in ceramide [92], with ceramide also shown to increase mitochondrial fusion and mitophagy in preeclampsia trophoblasts [93]. As to whether this is mediated by ceramide's inhibition of 14-3-3 and therefore the mitochondrial melatoninergic pathway requires investigation.…”
Section: Melatonin and Mitochondriamentioning
confidence: 99%
“…Emerging evidence indicates that ceramides, a type of sphingolipid, are located in the central hub of the sphingolipid metabolic network and have a role in regulating the development and reproduction of mammals and insects. Ceramides are present in the human placenta and are increased in the placental villous trophoblasts of insulin-treated gestational diabetes mellitus patients ( Mejia et al, 2019 ). High levels of ceramides were also detected in pregnancies complicated by preeclampsia ( Melland-Smith et al, 2015 ).…”
Section: Introductionmentioning
confidence: 99%