Differential Protein Expression in Serum of Abdominal Aortic Aneurysm Patients – A Proteomic Approach

Pulinx, B.; Hellenthal, F.A.M.V.I.; Hamulyák, Karly; Dieijen-Visser, Marja P. van; Schurink, Geert Willem H.; Wodzig, Will K. W. H.

doi:10.1016/j.ejvs.2011.07.019

Cited by 12 publications

(11 citation statements)

References 34 publications

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“…Significant correlations with expansion were found in 2 studies (1 low and 1 medium bias risk; r =0.55 and r =0.42) with 61 follow‐up patients in total,10, 39 whereas 2 studies (1 low and 1 medium bias risk) could not reproduce such significant correlations in 66 follow‐up patients 18, 40. Pulinx et al, however, did reach significance when initial AAA diameter was included in their multivariate model 40…”

Section: Resultsmentioning

confidence: 88%

“…In 9 studies, AAA diameter was described as a marker for expansion8, 17, 19, 21, 40, 56, 57, 58, 59 and in 9 as a marker for rupture 34, 37, 60, 61, 62, 63, 64, 65, 66. Overall, the data are reliable because 2570 patients in total were included and 8 studies were appraised with low bias risk, 7 with medium risk, and only 3 with high risk.…”

Section: Resultsmentioning

confidence: 99%

“…Overall, the data are reliable because 2570 patients in total were included and 8 studies were appraised with low bias risk, 7 with medium risk, and only 3 with high risk. In 7 studies, significant correlations with expansion were demonstrated in 958 patients in total ( r =0.30–0.83),8, 21, 40, 56, 57, 58 and Norman et al measured faster growth in patients with a large (≥4 cm; n=112) versus small AAA (3–4 cm; n=433) 19. In 6 studies, with a total of 552 patients, significant outcomes were demonstrated for AAA diameter as a marker for rupture.…”

Section: Resultsmentioning

confidence: 99%

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Systematic Review of Circulating, Biomechanical, and Genetic Markers for the Prediction of Abdominal Aortic Aneurysm Growth and Rupture

Groeneveld

Meekel

Rubinstein

et al. 2018

JAHA

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BackgroundThe natural course of abdominal aortic aneurysms (AAA) is growth and rupture if left untreated. Numerous markers have been investigated; however, none are broadly acknowledged. Our aim was to identify potential prognostic markers for AAA growth and rupture.Methods and ResultsPotential circulating, biomechanical, and genetic markers were studied. A comprehensive search was conducted in PubMed, Embase, and Cochrane Library in February 2017, following Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines. Study selection, data extraction, and methodological quality assessment were conducted by 2 independent researchers. Plausibility of markers was based on the amount of publications regarding the marker (more than 3), pooled sample size (more than 100), bias risk and statistical significance of the studies. Eighty‐two studies were included, which examined circulating (n=40), biomechanical (n=27), and genetic markers (n=7) and combinations of markers (n=8). Factors with an increased expansion risk included: AAA diameter (9 studies; n=1938; low bias risk), chlamydophila pneumonia (4 studies; n=311; medium bias risk), S‐elastin peptides (3 studies; n=205; medium bias risk), fluorodeoxyglucose uptake (3 studies; n=104; medium bias risk), and intraluminal thrombus size (5 studies; n=758; medium bias risk). Factors with an increased rupture risk rupture included: peak wall stress (9 studies; n=579; medium bias risk) and AAA diameter (8 studies; n=354; medium bias risk). No meta‐analysis was conducted because of clinical and methodological heterogeneity.ConclusionsWe identified 5 potential markers with a prognostic value for AAA growth and 2 for rupture. While interpreting these data, one must realize that conclusions are based on small sample sizes and clinical and methodological heterogeneity. Prospective and methodological consonant studies are strongly urged to further study these potential markers.

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Section: Resultsmentioning

confidence: 88%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Systematic Review of Circulating, Biomechanical, and Genetic Markers for the Prediction of Abdominal Aortic Aneurysm Growth and Rupture

Groeneveld

Meekel

Rubinstein

et al. 2018

JAHA

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“…These findings appear to be independent of fibrinogen or changes in thrombin generation; yet, other agents such as lipoprotein (a) or activated factor XII (fXIIa) may affect clot structure independent of thrombin [13]. Notably, lipoprotein (a) is elevated in AAA plasma versus control [14], and fXII activity correlates with aneurysm size [15]. These correlates may also contribute to the increased stiffness observed during the aging of ILT [12].…”

Section: Hemodynamics and Ilt Developmentmentioning

confidence: 82%

Biochemomechanics of Intraluminal Thrombus in Abdominal Aortic Aneurysms

Wilson

Virag

Achille

et al. 2013

Journal of Biomechanical Engineering

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Most computational models of abdominal aortic aneurysms address either the hemodynamics within the lesion or the mechanics of the wall. More recently, however, some models have appropriately begun to account for the evolving mechanics of the wall in response to the changing hemodynamic loads. Collectively, this large body of work has provided tremendous insight into this life-threatening condition and has provided important guidance for current research. Nevertheless, there has yet to be a comprehensive model that addresses the mechanobiology, biochemistry, and biomechanics of thrombus-laden abdominal aortic aneurysms. That is, there is a pressing need to include effects of the hemodynamics on both the development of the nearly ubiquitous intraluminal thrombus and the evolving mechanics of the wall, which depends in part on biochemical effects of the adjacent thrombus. Indeed, there is increasing evidence that intraluminal thrombus in abdominal aortic aneurysms is biologically active and should not be treated as homogeneous inert material. In this review paper, we bring together diverse findings from the literature to encourage next generation models that account for the biochemomechanics of growth and remodeling in patient-specific, thrombus-laden abdominal aortic aneurysms.

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“…2D-DIGE analysis and subsequent protein identifi cation using mass spectrometry was performed as described in Pulinx et al (7) with the following modifi cations. CSF samples were mixed with ice-cold acetone (1:4) (v/v) and incubated at -20 ° C for 60 min to remove salt from the samples.…”

mentioning

confidence: 99%

Detection of differential protein expression in cerebrospinal fluid of patients with multiple sclerosis through two-dimensional differential in gel electrophoresis

Pulinx

Hupperts

Vogt

et al. 2012

Clinical Chemistry and Laboratory Medicine (CCLM)

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Differential Protein Expression in Serum of Abdominal Aortic Aneurysm Patients – A Proteomic Approach

Cited by 12 publications

References 34 publications

Systematic Review of Circulating, Biomechanical, and Genetic Markers for the Prediction of Abdominal Aortic Aneurysm Growth and Rupture

Systematic Review of Circulating, Biomechanical, and Genetic Markers for the Prediction of Abdominal Aortic Aneurysm Growth and Rupture

Biochemomechanics of Intraluminal Thrombus in Abdominal Aortic Aneurysms

Detection of differential protein expression in cerebrospinal fluid of patients with multiple sclerosis through two-dimensional differential in gel electrophoresis

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